The therapeutic benefits of a concomitant approach to the disease and to the patient's identity experienced by the authors is illustrated by this case of a child presenting with dystonia musculorum deformans and severe disturbances of identity. This work was part of a research program concerning the function of these approaches and the operative modalities of their combinations.

Child↗

PubMedDate not supplied

[Nicardipine: vascular compliance and development of genetic hypertension in the SHR rat].

The potential preventive effects of nicardipine (100 mg/kg q.d., orally, for 6 weeks, starting at the 6th week of age) on genetic hypertension development (GHD) have been investigated in young SHRs. Furthermore, at the end of the treatment period, segments of mesenteric arteries were isolated in order to determine their vascular compliance and reactivity to noradrenaline and the total proteins content and the amount of DNA in the vascular wall. At the end of the treatment period and 20 hours after the last drug administration, nicardipine exhibited no preventive effects against GHD but heart rate was lower in treated than in control animals. Mesenteric vascular compliance was not treatment-affected but the maximal contractile response of the vessels to noradrenaline was slightly decreased. Finally, total proteins and DNA contents of the vascular wall were unchanged. It thus appears that there is a striking parallelism between nicardipine's lack of effects on resistance vessels' compliance and vascular total proteins and DNA contents on the one hand and the drug's inability to oppose GHD in young SHRs on the other.

Animals↗

PubMedDate not supplied

[Comparative beta-adrenoceptor blocking effects and pharmacokinetics of sotalol and propranolol in healthy volunteers].

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Adult↗

PubMedDate not supplied

[Experimental study of electro-ejaculation in the baboon (author's transl)].

With the aim of applying the technique of electro-ejaculation to paraplegics, the authors perfected an apparatus which permits stimulation with an intra-rectal electrode. Out of 27 electro-ejaculations carried out on 9 monkeys, there were 5 failures and 22 successes (but 3 of these only contained coagulum). The results improved at the same time as the technique. Although the motility and the number of spermatozoa were rather reduced in comparison with normal ejaculation, the semen obtained appeared to be utilizable. Observation of the animal, rectoscopy as well as the histological investigations carried out in 3 of the animals which were sacrificed showed no complication or lesion. The apparatus and technique which subsequently proved to be applicable in the paraplegic male should enable the improvement of his possibilities of procreation.

Animals↗