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Biomedical subjects

M Matsutani

Publications and source records attributed to M Matsutani.

150 records · Page 9Linked to original sources
PubMedDate not supplied

Combined treatment with chemotherapy and radiation therapy for intracranial germ cell tumors.

We analyzed our treatment results in 153 patients with histologically verified intracranial germ cell tumors and proposed classifying them into three therapeutic groups with good prognosis, intermediate prognosis, and poor prognosis. In this work, we selected patients treated with chemotherapy (cisplatin or carboplatin combinations) in each subgroup, and we discuss the role of chemotherapy in their treatment. Our combination chemotherapy regimens are: cisplatin-vinblastine-bleomycin, cisplatin-etoposide, and carboplatin-etoposide. We delivered these chemotherapies to the last 33 patients and compared their treatment results with those obtained in the previous 31 patients, who were treated with conventional radiation therapy alone. A combination with chemotherapy and a reduced dose of irradiation with local field was given to 7 patients with germinoma to increase the cure rate and reduce radiation-induced side effects, including anterior pituitary dysfunction. We obtained an excellent initial response to chemotherapy. The chemotherapy we delivered had significantly better effects in the group with intermediate prognosis, but not in the group with poor prognosis. More aggressive chemotherapy and radiation therapy should be given as the initial treatment.

Adolescent↗
PubMedDate not supplied

Clinical trial of intravenous infusion of bromodeoxyuridine (BUdR) for radiosensitization of malignant brain tumors.

Bromodeoxyuridine (BUdR) is a radiosensitizer that can be incorporated into cellular DNA as a substitute for thymidine at the time of DNA synthesis. As the steady-state arterial concentration of BUdR given by means of intravenous infusion was recently presented, the possibility of revival of BUdR as a radiosensitizer administered by the intravenous route was suggested. Based on the experience of BAR therapy and phase-I studies by NIH and UCSF, 12 hours of BUdR at a dose of 800-1,000 mg/m2 for five days a week was given to 23 patients with primary and secondary malignant brain tumors during radiation therapy. Radiation therapy was planned at a weekly dose of 10 Gy for five to six weeks. Fifteen patients received 1,000 mg/m2 of BUdR; six of them tolerated more than three weeks of treatment. In eight patients given doses of 800 mg/m2, five patients tolerated more than three weeks. The most remarkable toxic effects were myelosuppression and stomatitis, which were major obstacles to maintaining the schedule. More than 50% reduction of tumor volume was obtained in five of 12 cases of evaluated gliomas (42%) and three of four cases of metastatic tumors (75%). The median time to tumor progression in seven patients with glioblastoma was 37 weeks.

Adolescent↗
PubMedDate not supplied

Application of reconstruction computed tomography in a case of tuber cinereum hamartoma.

A case of a 2-year-old girl with tuber cinereum hamartoma is evaluated by computed tomography (CT). Special reference is made to the application of CT image reconstruction, which has not yet been reported in the literature. The location, extent, shape and size of the mass lesion and also the anatomical relationship to adjacent structures are clearly demonstrated in sagittal and coronal CT images reconstructed from serial thin-section CT images in conjunction with target imaging and a review program.

Child, Preschool↗
PubMedDate not supplied

Cavernous angioma of the middle fossa: a case report and characteristic MRI findings.

Cavernous angioma of the middle fossa is a rare lesion that is considered to originate from the cavernous sinus. Because of its profuse bleeding during surgery, it is crucial to make the correct diagnosis before an operation is performed. We report here a case of cavernous angioma occurring in the right middle fossa. MRI demonstrated an extracerebral mass extending from the middle cranial fossa into the cavernous sinus which showed low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Right carotid angiography demonstrated a faint vascular stain supplied by the meningohypophysial trunk. These findings suggested an extradural cavernous angioma originating from the cavernous sinus and extending into the middle-fossa.

Brain Neoplasms↗
PubMedDate not supplied

Astrocytomas arising in the tectal region of the mesencephalon: report of two cases.

Astrocytoma arising from the tectum of the mesencephalon is an unusual tumor that is different from other brain stem tumors in clinical features. We describe two patients with tectal low-grade astrocytoma. Each patient underwent CSF diversion and biopsy followed by radiation therapy. A review of the literature on the clinical, radiographic, and pathological findings and the management of tectal tumor is presented.

Adolescent↗