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Biomedical subjects

M Matsuo

Publications and source records attributed to M Matsuo.

At least 541 records · Page 30Linked to original sources
PubMed1980

The sensitivity to hyperbaric oxygen of human diploid fibroblasts during ageing in vitro.

The effect of hyperbaric oxygen on human diploid fibroblasts, WI-38, at various passages was examined. Their colony-forming ability deteriorates on exposure to hyperbaric oxygen. The cellular injury is not due to the high pressure per se, but to oxygen toxicity, since compressed nitrogen has no effect on the cells. When the cells beyond mid-40 population doublings (lifespan completed more than about 75%) are exposed to 50 atm of oxygen, there is a great decrease in the efficiency of the colony formation. A double exposure to 75 atm of oxygen inhibits the growth of the late passage cells more strongly than that of the early passage cells. These results suggest that the late passage cells are more sensitive to oxygen than the early passage cells.

Cell Survival↗
PubMed1980

A low-density inoculation method for the serial subcultivation of human diploid fibroblasts: an efficient model system for the study of cellular ageing.

Human diploid fibroblasts, TIG-1, were serially subcultivated at low inoculation densities thus maintaining the cultures in log phase throughout their in vitro lifespan. Their lifespan was shortened in calendar time without decreasing the cumulative number of population doublings when compared with the lifespan of cells serially cultivated by a standard method of 1:4 splitting. The cytokinetic and morphological changes during their lifespan are quite similar to those of control cells. The frequency of trypsinization doess not influence the cumulative number of population doublings. The "low-denstiy inoculation method" of subcultivation is efficiently and economically advantageous in studying cellular ageing in vitro.

Cell Division↗
PubMed1980

A study on hemodialysis leukopenia using various dialyzers.

Hemodialysis leukopenia was studied using various dialyzers and membranes. We found that dialyzers with cellulosic membranes caused marked leukopenia, but in recently developed non cellulosic membranes, its occurrence was significantly less. Additionally, our results showed a newly developed cellulose acetate membrane to correlate well with the non cellulose membranes regarding leukopenia, in spite of it being a derivative of cellulose. The extent of white blood cell decrease seemed to correlate inversely with an increase in the ultrafiltration rate per membrane area of dialyzer. The relationship between leukopenia and hypoxemia was examined also. The results of this investigation are included, however, we feel that more research is necessary before any conclusions can be made.

Cellulose↗
PubMed1980

Patterns of static prehension in normal hands.

For the purpose of classifying the patterns of static prehension in normal hands, the finger positions were photographed from 5 directions, while each of 7 normal adults held each of the 98 objects. The contact areas were also photographed from three to four directions. All sets of photographs were compared. Any two were considered identical in pattern when both the finger positions and the contact areas were alike. Fourteen identical patterns were identified: five patterns of power grip, four of intermediate grip, four of precision grip, and one other. Eighty-six percent of the grips shown by the subjects could be fitted into one of these prehension patterns, and the remaining 14 percent into intermediate or combined patterns. For all 7 subjects, 31 of 98 objects were grasped in an identical pattern and the rest of the objects, 67, in 2 or more patterns.

Persons with Disabilities↗