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Biomedical subjects

M Matsuno

Publications and source records attributed to M Matsuno.

65 records · Page 4Linked to original sources
PubMed1983

Effect of arterial infusion of bleomycin on esophageal carcinoma--an evaluation by nuclear cytophotometry.

In order to determine the histological changes after a single infusion of bleomycin (BLM) into the aortic esophageal artery (BLM A.I.), resected specimens from 58 patients with esophageal carcinoma (27 cases with BLM A.I., 14 untreated cases, 13 cases with radiation therapy and four cases with combined therapy of radiation and BLM) were examined and evaluated by Feulgen microspectrometry for nuclear deoxyribonucleic acid (DNA) content. The histological changes following the BLM A.I. were characterized by degeneration and necrosis at the front of the invading carcinoma tissue accompanied by inflammatory cell infiltration with foreign body giant cells and fibrosis. In comparison with untreated cases, BLM-treated cases showed an increase in nuclear DNA content and a wide dispersion of the DNA values especially at the perinecrotic area and at the front of advancing carcinoma nests. Therefore, a histological effect of the BLM A.I. was shown by the measurement of the nuclear DNA content of carcinoma cells.

Bleomycin↗
PubMed1978

Regional myocardial blood flow in regions of prior myocardial infarction before and after revascularization.

In 30 patients who received 102 saphenous vein bypass grafts, 91 were patent. Preoperative intracoronary injection of 99mTc-labeled albumin particles suspended in contrast revealed 81 regions of perfusion deficit which subsequently received successful revascularization. With postoperative graft injection of isotope, 48 of these regions no longer showed a perfusion deficit (59%), while 33 showed no change (41%). In these 30 patients, 16 of 17 (94%) revealed perfusion defects in regions of prior transmural myocardial infarction. Conversely, only 55 of 96 regions distal to coronary artery stenosis of greater than 50% revealed perfusion defects (57%). Thus, 99mTc-labeled microsphere studies seem to be valuable in detecting regions of prior infarction. After angiographically documented revascularization, the method continued to reveal perfusion deficits in 41% of abnormal regions noted preoperatively, even though almost half of these same specific regions showed improved postoperative regional contractility after postextrasystolic potentiation.

Cardiac Catheterization↗
PubMed1975

Metabolism of prostaglandins A1 and E1 in man.

To investigate the in vivo whole blood metabolic clearance rates and sites of metabolism of prostaglandins A1 and E1 in man, constant infusions of the tritiated compounds were administered to normal subjects and to patients undergoing cardiac catheterization. The whole blood metabolic clearance rate of [3H]prostaglandin A1 in eight men was 5,003 +/- 864 liters/day (SD) or 2,546 +/- 513 liters/day per m2 (SD). Nonradioactive prostaglandin A1 was similarly infused in two subjects, and the metabolic clearance rates were determined, utilizing a specific radioimmunoassay. The clearance rates with this method correlated closely with those determined by the isotope infusions. Extraction studies of prostaglandin A1 showed that pulmonary, splanchnic, renal, and extremity perfusions resulted in 8.1 +/- 4.1, 56.1 +/- 10.1, 50.3 +/- 3.4, and 34.4 +/- 5.9% (SEM) removal, respectively. With [3H]=prostaglandin E1, the whole blood metabolic clearance rate was determined from the pulmonary artery concentration in three patients and averaged 4,832 +/- 1,518 liters/day (SD) or 2,686 +/- 654 liters/day per m2 (SD). Pulmonary extraction was 67.8 +/- 6.8% (SEM) and extremity removal averaged 6.6 +/- 4.9% (SEM). These results indicate that A prostaglandins are metabolized by several organs, such as the liver and kidney, and possibly by intravascular pathways as well. In man, the E prostaglandins are primarily metabolized by the lung, but extraction is not complete and approximately one-third may escape lung metabolism. Thus, these findings suggest that both E and A prostaglandins in the venous circulation may reach the systemic circulation in man.

Abdomen↗