A total synthesis of grifolin.
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Biomedical subjects
Publications and source records attributed to M Matsukawa.
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Cases of a metastatic involvement of the stomach from a colorectal cancer are extremely rare, and once such case, confirmed by autopsy, is reported. The patient, an 86-year-old woman, had a metastatic lesion of the stomach from a rectal cancer. The rectal cancer was a combined linitis plastica type and signet ring cell carcinoma, and the appearance of metastatic lesion of the stomach had simulated the linitis plastica type cancer. A metastatic involvement of the stomach presenting a linitis plastica type cancer from a breast cancer is well documented, but a linitis plastica type from a colorectal cancer has not been reported. This case is the first report concerning a gastric metastasis presenting linitis plastica type lesion from a colorectal cancer.
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This study was undertaken to evaluate the radiological diagnosis of colorectal polypoid lesions between 0.6 cm and 3.0 cm in size. Lesions less than 0.6 cm were mostly benign or, on rare occasions, early carcinomas limited to the mucosa. Lesions more than 3.0 cm in size were mostly advanced carcinomas. Lesions were classified by modified Maruyama's classifications as follows, type "a" (lesion with long stalk), type "b" (lesion with short or sessile lesion), type "c" (plaque-like lesion), type "d" (lesion with central depression) and type "e" (the others). Type "a" lesions were either benign or early cancers but these could not be distinguished radiologically. Type "b" and "c" lesions more than 1.0 cm in size and with indentation of colonic wall, had a great probability of being early cancer. Type "d" lesions with a slight depression were either benign or early cancers but type "d" lesion with a moderate depression were all advanced cancers. Type "e" lesions were mostly villous tumors so that it was difficult to diagnose whether these were cancer or not.
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Resected or polypectomized materials of colo-rectal cancer are morphologically analyzed in order to estimate their developing pattern. A retrospective review of previous radiological or endoscopic findings is also made in the patients who had either or both of examinations in the past. Morphologically, a distribution chart of colo-rectal cancers by their size and height is made, and a zone of colo-rectal cancers with the same morphological features is drawn. Retrospectively, type 1 advanced cancer appears to develop from Is type early cancer, and morphologically, a zone of Is type early cancers and that of type 1 advanced cancers partly overlap each other. The retrospective review also suggests that type 2 advanced cancer seems to develop from type Is, IIa or IIa + IIc early cancer. On the distribution chart, a zone of type 2 advanced cancer is partly superimposed over or bordered by that of early cancers type Is, IIa or IIa + IIc. Thus, it may fairly be said that advanced cancer develops from early cancer with its zone on the distribution chart partly superimposed over or bordered by that of the advanced cancer. Among early cancers, sessile type, superficial elevated type or elevated type with central depression may develop to advanced cancer. Both morphological analysis and retrospective radiological or endoscopic review of colo-rectal cancers would suggest the developing pattern of pedunculated or flat type early cancer.
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Investigation was made on the effectiveness and safety of amikacin (AMK) in the treatment of bacterial infections and prevention of postoperative infections in the orthopedic field. The details of 14 infectious patients treated with AMK were as follows; osteomyelitis in 5, purulent arthritis in 3, decubitius in 3, cystitis in 2 and purulent peritonitis in 1. For prevention of postoperative infections, AMK was administered to 9 patients. In 14 infectious patients, clinical response was excellent in 2, good in 11 and poor in 1, while in 9 postoperative patients clinical response was excellent or good in all of them. As side effects, a slight rise of the GOT and GPT levels was observed in 1 but normalized by discontinuation of the medication. In the aspects of effectiveness and safety, AMK may be considered to be a useful available antibiotic in the orthopedic field.
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