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Biomedical subjects

M Matsui

Publications and source records attributed to M Matsui.

At least 505 records · Page 28Linked to original sources
PubMed1982

Developmental alteration of hepatic UDP-glucuronosyltransferase and sulphotransferase towards androsterone and 4-nitrophenol in Wistar rats.

Postnatal development of hepatic UDP-glucuronosyltransferase and sulphotransferase activities towards androsterone and 4-nitrophenol as well as cytochrome P-450 contents was studied in male and female Wistar rats. The rats with high and low UDP-glucuronosyltransferase activity towards androsterone were classified by the genotype of the parent animals. UDP-glucuronosyltransferase activity towards androsterone began rapidly to enhance after 30 days of age in the high-activity group, whereas the transferase activity remained low throughout in the low-activity group. Such a striking difference was not observed in UDP-glucuronosyltransferase activity towards 4-nitrophenol, sulphotransferase activity towards androsterone and 4-nitrophenol, and cytochrome P-450 contents. Sex-based difference in the sulphotransferase activity was marked after 30 days of age. Sulphotransferase activity towards androsterone was much higher in adult females than in adult males, whereas higher sulphation activity towards 4-nitrophenol was found in adult males. The results also indicate that the low level of the UDP-glucuronosyltransferase activity did not lead to compensatory stimulation of the sulphotransferase activity.

Age Factors↗
PubMed1982

Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.

Male and female Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone were classified by partial hepatectomy. The breeding experiments between the classified high-activity and low-activity rats show that the genetic expression of the high transferase activity is inherited in an autosomal dominant fashion.

Androsterone↗
PubMed1982

Ophthalmoscopic model of nerve fiber bundle defects in monkey eyes produced by intraocular retinal coagulation.

The development of nerve fiber bundle defects in monkey eyes by means of intraocular retinal coagulation, such as endodiathermy, intraocular cryotherapy or endophotocoagulation was confirmed by ophthalmoscopy. Two to 4 days after the application of intraocular retinal coagulation, the findings could be already observed. Endodiathermy especially could provide the typical ophthalmoscopic findings of nerve fiber bundle defects without any abnormal fluorescein angiographic findings, while endophotocoagulation and intraocular cryotherapy induced hyperfluorescence due to window defect at the coagulation site. Therefore, endodiathermy in monkey eyes can provide an excellent ophthalmoscopic model of the nerve fiber bundle defects. Histological findings 8 weeks after the coagulation showed thinning of the retinal nerve fiber layer and gliosis occurring in the retinal portion corresponding to the lesion.

Animals↗
PubMed1982

Formation of N-nitroso compounds during cooking of Japanese food.

N-Nitrosamines in several traditional Japanese meals, such as 'Nebemono', 'Ten-pura' and Kara-age', were analysed. No appreciable amount, or only trace quantities, of NDMA and NPYR could be detected in these meals. The effects of various gases on nitrosamine formation in dried squid have been examined at higher cooking temperatures and the highest yield of NDMA was observed by exposure to the gas produced by the combustion of kerosene, followed by that of city gas, while very low levels of NDMA were formed when samples were wrapped in aluminium foil or broiled in air or argon atmospheres. The principal precursor of NDMA in dried squid was found to be TMAO, which is abundant in the squid muscle and from which nitrosatable DMA can be produced during broiling at higher temperatures.

Cooking↗