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Biomedical subjects

M Matei

Publications and source records attributed to M Matei.

At least 19 recordsLinked to original sources
PubMed1998

Cervical intraepithelial neoplasia and HPV infection.

Human papillomavirus (HPV) infection has been recognized as the major cause of cervical cancer [1]. The transformation zone of the cervix is the most frequent target of the high risk HPV types. In our study infection with HPV16 and 18 was investigated in the cervical scrapes of 28 subjects with cervical intraepithelial neoplasia. The DNAs isolated from the samples were amplified by dot-blot hybridization with fragmented digoxygenin labelled probes. Eighteen of 28 patients (64.3%) were found positive for HPV-16, eleven (39.3%) were found positive for HPV-18 and six patients (21%) were infected with both HPV types. This method is practical and sensitive for determining patients with a higher risk of developing HPV-related cancer.

Adolescent↗
PubMed1998

[Postpartum myocardial infarction induced by Parlodel].

The authors report the case of a 28 year old woman who developed antero-septoapical myocardial infarction in the post-partum period. This was detected by surface ECG and echocardiography performed after a systemic embolism. The infarction followed treatment with Parlodel for inhibition of lactation. Coronary angiography, performed one month post-partum, was normal and the methergin test was negative. The physiopathological mechanism of myocardial infarction resulted from the association of an iatrogenic spastic phenomenon favourised by the patient restarting to smoke and the physiological arterial hyperactivity of the post-partum period. This mechanism raises the question of preventive measures in cases of inhibition of lactation in the post-partum period, notably stopping smoking.

Adult↗
PubMed1997

Predictive value of clinical indices in detecting aspiration in patients with neurological disorders.

OBJECTIVES: (1) To evaluate the predictive value of a detailed clinical screening of aspiration in patients with neurological diseases, both with and without symptoms of dysphagia taking videofluoroscopy as the gold standard; (2) to assess the existence of risk factors for silent aspiration, measuring the cost-benefit ratio of radiological examination. METHODS: 93 consecutive patients meeting the diagnostic criteria for a neurological disease with a risk of swallowing dysfunctions (cerebrovascular accidents, brain injury, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, myotonic dystrophy, and abiotrophic diseases) underwent a detailed clinical assessment using a 25 item form to check for symptoms of dysphagia and impairment of the oropharyngeal swallowing mechanism. The 3 oz water swallow test was also performed to assess the aspiration risk. Sensitivity, specificity, positive predictive, and negative predictive values (NPV) of dysphagia, history of cough on swallowing, and 3 oz test positivity, versus videofluoroscopy documented aspiration, taken as the gold standard, were measured in all the patients and in subgroups with different neurological disorders. RESULTS: Non-specific complaints of dysphagia showed a very poor predictive value, whereas the symptom "cough on swallowing" proved to be the most reliable in predicting the risk of aspiration, with 74% sensitivity and specificity, 71% positive predictive, and 77% negative predictive value. The standardised 3-oz test had a higher predictive potential than the clinical signs, but had low sensitivity. The association of cough on swallowing with the 3 oz test gave a positive predictive of 84%, and an negative predictive value of 78%. In cases where the clinical tests failed to detect any impairment, videofluoroscopy documented only a low risk (20%) for mild aspiration. CONCLUSIONS: The association of two clinical items (such as history of cough on swallowing and 3 oz test positivity) provides a useful screening tool, the cost:benefit ratio of which seems very competitive in comparison with videofluoroscopy in aspiration risk evaluation.

Adolescent↗
PubMed1989

[The experience of paramedical personnel in the cardiopulmonary resuscitation of acute cardiac patients].

The cardiac stop as well as the severe despondency of the respiratory function in the recoverable patients is a major medical urgency which causes the immediate death of the patient if efficient measures of cardiorespiratory resuscitation are not correctly and rapidly taken. The authors describe in detail the measures to be taken in such situations, presenting the experience of the medical and nursing staff in the coronary intensive care unit of the Medical Clinic III, in the Clinical Hospital of Bucharest. It is underlined the fact that due to the nature of their tasks, the nursing staff have an essential contribution within the "team work" of the coronary intensive care units.

Acute Disease↗
PubMed1979

Influence of temporal lobe lesions on photic-evoked responses in occipital visual areas.

In 20 patients with temporal lobe lesions and 10 controls, the averaged photic-evoked responses (APERs) and their dispersion pattern (DP) were investigated in inion-vertex-lead and bilaterally in inion-parietal leads (I-P3 and I-P4). The patients with temporal lobe lesions, regardless of lesion location in temporal areas, displayed either absence of APER (the whole APER or only the initial components) or a latency increase without amplitude changes. The DP was generally abnormal. The role of the temporal lobe in the organization of APER in visual areas is discussed.

Adult↗
PubMed1976

Visual evoked responses and their dispersion pattern in frontal lobe tumours.

In patients with frontal lobe tumours the averaged visual evoked responses (AVER) and their dispersion pattern (DP) in visual areas were investigated before and at different periods after operation. Important changes in AVER (in amplitude and latency) were found in the patients with tumours on the midline or in one of the frontal lobes. The DP was abnormal in all the cases. There was no relation to visual acuity, tumour location and existance of intracranial hypertension. After operation, despite the clinical improvement, the alterations of AVERs or DPs were very marked and in some cases became even more important than before. The role of the frontal lobe in the organization of the responses to peripheral stimuli in the visual areas is discussed.

Adult↗
PubMed1976

Neocortical reactivity to peripheral stimuli in neurotics.

The averaged photic-evoked responses (APER) and their dispersion pattern (DP) were investigated in tired subjects, neurotics and patients with neurotic syndromes. The appearance of an ample late negative deflection (N3) followed by a deep positive one (P3) of APER and of an atypical DP in tired subjects, neurotics and in patients with neurotic syndromes, may be considered signs of tiredness and of attention lability. A lengthening of the latencies and decrease in amplitude of different APER components, found in neurotics and in patients with neurotic syndromes only, indicated abnormalities in the function of neuronal structures involved in the organizations of responses to peripheral stimuli.

Adult↗
PubMed1974

Visual evoked responses and their dispersion pattern in neurotic patients.

The AVER (averaged visual evoked responses) and the DP (a pattern of dispersion resulting from the variability of each time point locked to the stimulus onset: D = F [T]) were studied in neurotics in comparison with controls. In neurotics without depression and/or anxiety the AVERs were normal and the DPs showed a shortening of the second period; in neurotics with depression and/or anxiety the AVER'S were also normal but the second period of the DPs disappeared.

Adjustment Disorders↗