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Biomedical subjects

M Massoud

Publications and source records attributed to M Massoud.

23 records · Page 2Linked to original sources

Polarization fluoroimmunoassay of 11-deoxycortisol in serum and saliva.

We developed polarization fluoroimmunoassays for 11-deoxycortisol in serum and saliva. To avoid interfering factors, the steroid was initially extracted from the biological fluids with dichloromethane. Assays could then be completed without any further separation procedures or need to correct for blank signals. The serum assay was suitable for following the response to the metyrapone test and results correlated acceptably with those by an established, specific, direct 125I-radioimmunoassay. The method is not sufficiently sensitive to detect 11-deoxycortisol in normal saliva, but greatly increased concentrations were found in post-metyrapone saliva and results agreed well with those by the radioimmunoassay as modified for salivary assay. Salivary 11-deoxycortisol assay would provide a convenient means of monitoring results of the metyrapone test.

17-Hydroxycorticosteroids↗

Dynamic loads experienced in correction of idiopathic scoliosis using two types of Harrington rods.

This paper reports the results of a series of tests conducted to evaluate the dynamic loads exerted by the Harrington rod on the vertebral bones during the correction of idiopathic scoliosis. Two types of Harrington rods were tested: the standard stepped rod and a modified threaded rod. The latter had a threaded end replacing the standard stepped end. The tests were conducted on linear and nonlinear springs, the mechanical characteristics of which are similar to those previously obtained from measurements performed on human spines. The results of the tests are reported and the two rod designs are evaluated accordingly. The modified threaded rod shows definite mechanical advantages over the stepped rod; however, the design is still open for modifications to overcome certain functional difficulties. (The Custom Product Services of Zimmer Co. offers a child spinal threaded rod designed by Dr. Kenton Leatherman.)

Biomechanical Phenomena↗