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M Marshall

Publications and source records attributed to M Marshall.

At least 181 records · Page 10Linked to original sources
PubMed1984

Interactions between carbamyl phosphate synthase-I-mitochondrial aspartate aminotransferase and palmitoyl-CoA.

Carbamyl phosphate synthase-I and glutamate dehydrogenase both form a complex with mitochondrial aspartate aminotransferase. Instead of these two enzymes competing for the aminotransferase, carbamyl phosphate synthase-I enhances glutamate dehydrogenase-aminotransferase interaction. This suggests that a complex can be formed between all three enzymes. Since this complex is stable in the presence of substrates and modifiers of the three enzymes, it could conceivably convert NH+4 produced from aspartate into carbamyl phosphate. Furthermore, since carbamyl phosphate synthase-I is the predominant protein in liver mitochondria, it could play a major role in placing the aminotransferase and glutamate dehydrogenase in close proximity. Malate removes glutamate dehydrogenase from the tri-enzyme complex and thus could play a role in determining whether glutamate dehydrogenase interacts with carbamyl phosphate synthase-I or is available to participate in reactions with the Krebs cycle. Palmitoyl-CoA has a high affinity for both carbamyl phosphate synthase-I and glutamate dehydrogenase. ATP and malate which, respectively, decrease and enhance binding of palmitoyl-CoA to glutamate dehydrogenase, respectively decrease and enhance the ability of this enzyme to compete with carbamyl phosphate synthase-I for palmitoyl-CoA. Since carbamyl phosphate synthase-I is present in high levels in liver mitochondria and has a high affinity for palmitoyl-CoA, it could play a major role as a reservoir for palmitoyl-CoA.

Acyl Coenzyme A↗
PubMed1984

[Prevalence, risk factors and complications of peripheral venous diseases in the Munich population].

Prevalence, risk factors, and complications of peripheral venous disease of the lower limb were examined in a prospective study on 1,000 unselected outpatients of a polyclinic. The investigation was planned as a representative epidemiologic study in the Munich area, with the intention of getting information on the sociomedical importance, therapy, and possibilities of prevention of peripheral venous disease. Prevalence. Of the patients examined 50% showed peripheral venous abnormalities, which were unimportant in 25%, relevant in 10%, and pathologic in 15%, i.e., one of seven patients had significant venous problems. No significant differences dependent on sex were found. The prevalence of peripheral venous disease grew with increasing age. Medical reliability. The striking sociomedical importance of peripheral venous disease was demonstrated by the high rate of complications, such as thrombophlebitis, chronic venous stasis, and embolism. Nearly every other person with pathologic venous changes suffered from thrombophlebitis, every 3rd from a chronic venous stasis, every 4th from ulcera of the legs and every 10th from embolism. Risk factors. Especially the varicose saphenous veins seemed to depend on risk factors such as overweight, standing position at work, herniae, flat and/or spread feet, familial disposition, age and pregnancy. In women and men peripheral venous disease proved to be very closely correlated with a positive familial disposition. In male patients there were further correlations with hernias and a standing position at work, and in women with flat or spread feet. Overweight, pregnancy or multiple pregnancies are recognized as aggravating factors with only tendentious correlations. The most important recommendation to people with peripheral venous disease is early medical treatment to prevent progressive disease. Complications can probably be markedly reduced by early treatment.

Adult↗
PubMed1983

Ureterolithotomy for juxtavesicular stone.

Stones within the distal 8 cm. of the ureter often can be approached more readily through the posterior wall of the bladder than extravesically. The method and its indications are described.

Humans↗
PubMed1982

[Ergotism].

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Angiography↗