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M Marmot

Publications and source records attributed to M Marmot.

At least 91 records · Page 5Linked to original sources
PubMed1998

Design, objectives, and lessons from a pilot 25 year follow up re-survey of survivors in the Whitehall study of London Civil Servants.

DESIGN: To assess the feasibility of conducting a re-survey of men who are resident in the United Kingdom 25 years after enrollment in the Whitehall study of London Civil Servants. METHODS: A random sample of 401 study survivors resident in three health authority areas was selected for this pilot study. They were mailed a request to complete a self administered questionnaire, and then asked to attend their general practice to have their blood pressure, weight, and height measured and a blood sample collected into a supplied vacutainer, and mailed to a central laboratory. Using a 2 x 2 factorial design, the impact of including additional questions on income and of an informant questionnaire on cognitive function was assessed. RESULTS: Accurate addresses were obtained from the health authorities for 96% of the sample. Questionnaires were received from 73% and blood samples from 61% of the sample. Questions on income had no adverse effect on the response rate, but inclusion of the informant questionnaire did. Between 1970 and 1995 there were substantial changes within men in the mean blood pressure and blood total cholesterol recorded, as reflected by correlation coefficients between 1970 and 1995 values of 0.26, and 0.30 for systolic and diastolic blood pressure and 0.38 for total cholesterol. CONCLUSION: This pilot study demonstrated the feasibility of conducting a re-survey using postal questionnaires and mailed whole blood samples. The magnitude of change in blood pressure and blood total cholesterol concentrations within individuals was greater than anticipated, suggesting that such remeasurements may be required at different intervals in prospective studies to help interpret risks associations properly. These issues will be considered in a re-survey of the remaining survivors of the Whitehall study.

Aged↗
PubMed1998

Socioeconomic and sex differentials in reason for sickness absence from the Whitehall II Study.

OBJECTIVES: Large socioeconomic differences exist in disease and mortality. This paper describes the distribution of specific medical reasons for sickness absence by grade of employment in the Whitehall II study and validates the medical reason by comparison with general practitioners' records. METHODS: Analysis of sickness absence data on 5620 male and female civil servants aged 35-55 years. Data have been collected from 12 of the 20 London based civil service departments participating in the Whitehall II study, where medical reason for absence was available. Rates and distributions of reasons for absence for short spells (< or = 7 days) and long spells (> 7 days) were analysed. RESULTS: Respiratory disorders and gastroenteritis accounted for over half of all spells of absence, with headache and migraine, musculoskeletal disorders, injury, and neurosis accounting for a further 20%-30% of absences. There was an inverse association with employment grade, the lower the grade the higher the rate of absence for both short spells (< or = 7 days) and long spells (> 7 days). In general, women had higher rates of absence than men. Comparison of reason for very long spells of absence (> 21 days) showed moderate agreement between civil service and general practitioner. CONCLUSION: There is a lack of national comprehensive data on sickness absence and medical reason for absence, in particular for women and for spells of different duration. Data from the Whitehall II study show large employment grade and sex differences in the distribution of medical reasons for absence that are similar to socioeconomic differences in morbidity documented in other studies. Possible explanations include the subjective nature of illness and disease; the work/family interface; and the influence of the absence culture. Longer term follow up will provide information on whether sickness absence relates to serious morbidity and mortality.

Absenteeism↗
PubMed1998

Two alternative job stress models and the risk of coronary heart disease.

OBJECTIVES: This study examined the association between two alternative job stress models-the effort-reward imbalance model and the job strain model-and the risk of coronary heart disease among male and female British civil servants. METHODS: The logistic regression analyses were based on a prospective cohort study (Whitehall II study) comprising 6895 men and 3413 women aged 35 to 55 years. Baseline measures of both job stress models were related to new reports of coronary heart disease over a mean 5.3 years of follow-up. RESULTS: The imbalance between personal efforts (competitiveness, work-related overcommitment, and hostility) and rewards (poor promotion prospects and a blocked career') was associated with a 2.15-fold higher risk of new coronary heart disease. Job strain and high job demands were not related to coronary heart disease; however, low job control was strongly associated with new disease. The odds ratios for low job control were 2.38 and 1.56 for self-reported and externally assessed job control, respectively. Work characteristics were simultaneously adjusted and controlled for employment grade level, negative affectivity, and coronary risk factors. CONCLUSIONS: This is apparently the first report showing independent effects of components of two alternative job stress models-the effort-reward imbalance model and the job strain model (job control only)-on coronary heart disease.

Adult↗
PubMed1998

Association between psychosocial factors at work and nonfatal myocardial infarction in a population-based case-control study in Czech men.

We examined the effect of decision latitude and work demand on risk of myocardial infarction in a former Soviet Bloc country and analyzed whether these factors contributed to the educational gradient in myocardial infarction in this population. We conducted a case-control study among full-time working men in the general population of five districts of the Czech Republic. Cases were 179 men 25-64 years of age with a first nonfatal myocardial infarction diagnosed in selected districts over a 1-year period, and controls were 784 men in the same age group randomly selected from the population register. We used logistic regression to estimate the odds of developing myocardial infarction in relation to self-reported work demand and decision latitude at work and the contribution of these factors as well as standard risk factors to socioeconomic differences in the risk of myocardial infarction. Cases reported lower decision latitude and lower work demand than controls. Age-adjusted odds ratios for the highest vs lowest quartiles of decision latitude and work demand were 0.43 (95% confidence interval = 0.25-0.75) and 0.54 (95% confidence interval = 0.31-0.93), respectively. Further adjustment for coronary risk factors and education did not change these estimates. Decision latitude accounted for part of the association between education and myocardial infarction, and decision latitude and risk factors jointly explained virtually all of it. The association between decision latitude at work and myocardial infarction found in our study is consistent with research in western populations and may partly explain the socioeconomic gradient in myocardial infarction.

Adult↗
PubMed1997

Is the SF-36 a valid measure of change in population health? Results from the Whitehall II Study.

OBJECTIVE: To measure within-person change in scores on the short form general health survey (SF-36) by age, sex, employment grade, and disease status. DESIGN: Longitudinal study with a mean of 36 months (range 23-59 months) follow up, with screening examination and questionnaire to detect physical and psychiatric morbidity. SETTING: 20 civil service departments originally located in London. PARTICIPANTS: 5070 male and 2197 female office based civil servants aged 39-63 years. MAIN OUTCOME MEASURES: Change in the eight scales of the SF-36 (adjusted for baseline score and length of follow up) and effect sizes (adjusted change standard deviation of differences). RESULTS: Within-person declines (worsening health) with age were greater than estimated by cross sectional data alone. General mental health showed greater declines among younger participants (P for linear trend < 0.001). Employment grade was inversely related to change; lower grades had greater deteriorations than higher grades (P < 0.001 for each scale in men; P < 0.05 for each scale in women except general health perceptions and role limitations due to physical problems). The greatest declines were seen among participants with disease at baseline, with the effects of physical and psychiatric morbidity being additive. Effect sizes ranged from 0.20 to 0.65 in participants with both physical and psychiatric morbidity. CONCLUSIONS: Health functioning, as measured by the SF-36, changed in hypothesised directions with age, employment grade, and disease status. These changes occurred within a short follow up period, in an occupational, high functioning cohort which has not been the subject of intervention, suggesting that the SF-36 is sensitive to changes in health in general populations.

Adolescent↗
PubMed1997

Ecological analysis of collectivity of alcohol consumption in England: importance of average drinker.

OBJECTIVE: To assess whether the average consumption of alcohol is associated with the prevalence of heavy drinking, problem drinking, and abstention in England. DESIGN: Ecological analysis using data from a cross sectional household based survey of English adults. SUBJECTS: Random sample of 32,333 adults from the English population who participated in the 1993 and 1994 health surveys for England. MAIN OUTCOME MEASURES: Association, expressed as the correlation coefficient, between the regional mean and median alcohol consumption and the regional prevalence of heavy drinking, problem drinking, and abstention. RESULTS: Mean consumption of alcohol in light to moderate drinkers was strongly positively associated with the prevalence of heavy drinking (r = 0.75 in men and r = 0.62 in women for drinking more than 21 and 14 units per week respectively). A similar association was found between median consumption and prevalence of heavy drinking. Abstention was not significantly associated with mean consumption in drinkers (r = 0.08 for men and r = -0.29 for women). Both the median and mean consumption in drinkers were positively associated with the prevalence of problem drinking as defined by the CAGE questionnaire on alcohol use (r = 0.53 for men and r = 0.42 for women for the association with mean consumption). CONCLUSION: Factors that increase the average consumption of alcohol in the population may result in an increase in the prevalence of heavy drinking and related problems.

Adult↗
PubMed1997

Social inequalities in health: next questions and converging evidence.

Mortality studies show that social inequalities in health include, but are not confined to, worse health among the poor. There is a social gradient: mortality rises with decreasing socio-economic status. Three large sample studies, one British and two American, brought together for their complementarity in samples, measures, and design, all show similar social gradients for adult men and women in physical and mental morbidity and in psychological well-being. These gradients are observed both with educational and occupational status and are not explained by parents' social status or lack of an intact family during childhood. They are also not accounted for by intelligence measured in school. This suggests that indirect selection cannot account for inequalities in health. Possible mediators that link social position to physical and mental health include smoking and features of psycho-social environment at work and outside.

Adult↗
PubMed1997

Social support and psychiatric sickness absence: a prospective study of British civil servants.

BACKGROUND: Studies on the direct and buffering effects of social support have not examined psychiatric sickness absence and few studies have considered support both at home and at work. This study addresses prospectively the effects of chronic stressors and social supports, at home and at work, on psychiatric sickness absence rates. METHODS: Sociodemographic factors, health and social support were measured at baseline, and short and long spells of sickness absence were measured prospectively over a 5-year period. The participants were a subsample of 4202 male and female civil servants, aged 35-55 years at baseline, from an occupational cohort, the Whitehall II Study, who completed detailed social support questions. RESULTS: Support from colleagues and supervisors at work is related to lower risk of short spells of psychiatric sickness absence, particularly for those also receiving high levels of negative aspects of close relationships from their closest person outside work. Negative aspects of close relationships from the closest person increase the risk of taking long spells of psychiatric sickness absence in men. High levels of material problems increase the risk of short spells of sickness absence. CONCLUSIONS: Negative aspects of close relationships may have an aetiological role in non-psychotic psychiatric disorder. Social support at work appears to protect against short spells of psychiatric sickness absence. This potentially implies that levels of short spells of absence might be reduced by increasing support at work. Conversely, emotional support at home may influenced absence-related behaviour and encourage a person to take absence at a time of illness.

Absenteeism↗
PubMed1997

Political changes and trends in cardiovascular risk factors in the Czech Republic, 1985-92.

BACKGROUND: Mortality from cardiovascular diseases is substantially higher in central and eastern Europe than in the west. After the fall of communism, these countries have undergone radical changes in their political, social, and economic environments but little is known about the impact of these changes on health behaviours or risk factors. Data from the Czech Republic, a country whose mortality rates from cardiovascular diseases are among the highest, were analysed in this report. OBJECTIVES: To examine the trends in cardiovascular risk factors in Czech population over the last decade during which a major and sudden change of the political and social system occurred in 1989, and whether the trends differed in relation to age and educational group. DESIGN AND SETTING: Data from three cross sectional surveys conducted in 1985, 1988, and 1992 as a part of the MONICA project were analysed. The surveys examined random samples of men and women aged 25-64 in six Czech districts and measured the following risk factors: smoking, blood pressure, body mass index (BMI), and total and high density lipoprotein (HDL) cholesterol. RESULTS: The numbers of subjects (response rate) examined were 2573 (84%) in 1985, 2769 (87%) in 1988, and 2353 (73%) in 1992. Total cholesterol and body mass index increased between 1985 and 1988 and decreased between 1988 and 1992. The prevalence of smoking was declining slightly in men between 1985 and 1992 but remained stable in women. There were only small changes in blood pressure. The decline in cholesterol and BMI in 1988-92 may be related to changes in foods consumption after the price deregulation in 1991. An improvement in risk profile was more pronounced in younger age groups, and the declines in cholesterol and obesity were substantially larger in men and women with higher education. By contrast, there was an increase in smoking in women educated only to primary level. CONCLUSION: Substantial changes in cholesterol, obesity, and women's smoking occurred in the Czech population after the political changes in 1989. Although a causal association cannot be claimed, national trends in foods consumption are consistent with changes in blood lipids and obesity. Further monitoring of trends is required to confirm these trends.

Adult↗
PubMed1997

Can dietary interventions change diet and cardiovascular risk factors? A meta-analysis of randomized controlled trials.

OBJECTIVES: This study evaluated the effectiveness of dietary advice in primary prevention of chronic disease. METHODS: A meta-analysis was conducted of 17 randomized controlled trials of dietary behavior interventions of at least 3 months' duration. Results were analyzed as changes in reported dietary fat intakes and biomedical measures (serum cholesterol, urinary sodium, systolic and diastolic blood pressure) in the intervention group minus changes in the control group at 3 to 6 months and 9 to 18 months of follow-up. RESULTS: After 3 to 6 months, mean net changes in each of the five outcomes favored intervention. For dietary fat as a percentage of food energy, the change was -2.5% (95% confidence interval [CI] = -3.9%, -1.1%). Mean net changes over 9 to 18 months were as follows: serum cholesterol, -0.22 (95% CI = -0.39, -0.05) mmol/L; urinary sodium, -45.0 (95% CI = -57.1, -32.8) mmol/24 hours; systolic blood pressure, -1.9 (95% CI = -3.0, 0.8) mm Hg; and diastolic blood pressure, -1.2 (95% CI = -2.6, 0.2) mm Hg. CONCLUSIONS: Individual dietary interventions in primary prevention can achieve modest improvements in diet and cardiovascular disease risk status that are maintained for 9 to 18 months.

Cardiovascular Diseases↗
PubMed1997

The impact of socioeconomic status on health functioning as assessed by the SF-36 questionnaire: the Whitehall II Study.

OBJECTIVES: This study measured the association between socioeconomic status and the eight scale scores of the Medical Outcomes Study short form 36 (SF-36) general health survey in the Whitehall II study of British civil servants. It also assessed, for the physical functioning scale, whether this association was independent of disease. METHODS: A questionnaire containing the SF-36 was administered at the third phase of the study to 5766 men and 2589 women aged 39 through 63 years. Socioeconomic status was measured by means of six levels of employment grades. RESULTS: There were significant improvements with age in general mental health, role-emotional, vitality, and social functioning scale scores. In men, all the scales except vitality showed significant age-adjusted gradients across the employment grades (lower grades, worse health). Among women, a similar relationship was found for the physical functioning, pain, and social functioning scales. For physical functioning, the effect of grade was found in those with and without disease. CONCLUSIONS: Low socioeconomic status was associated with poor health functioning, and the effect sizes were comparable to those for some clinical conditions. For physical functioning, this association may act both via and independently of disease.

Adult↗
PubMed1997

Sickness absence from back pain, psychosocial work characteristics and employment grade among office workers.

OBJECTIVES: The relation between psychosocial work characteristics, employment grade, and sickness absence due to back pain was studied among office workers. METHODS: Base-line questionnaire data and sickness absence data collected continuously with a mean of 4 years of follow-up were analyzed. The subjects were 6894 men and 3414 women aged 35 to 55 years at recruitment. The main outcome measures were short (< or = 7 days) and long (> 7 days) absences due to back pain. RESULTS: There was a strong inverse association between employment grade and rate of absences due to back pain (P for linear trend < 0.001); for example, the rate ratio for short absences among the men in a comparison of lowest versus highest employment grade was 8.21. The age adjusted rate ratio for the effect of low versus high control over work among the men was 2.22 [95% confidence interval (95% CI) 1.77-2.79] for short and 1.61 (95% CI 1.01-2.58) for long absences due to back pain. For short absences due to back pain among the men in high grades of employment, the rate ratio for low control was 3.42 compared with 0.78 for the lower grades (P for interaction < 0.001). For the women the corresponding rate ratios were 0.80 and 1.35, respectively (P for interaction 0.08). CONCLUSIONS: Absence from work due to back pain was strongly inversely related to employment grade. The effects of psychosocial work characteristics-particularly control-differed by grade and gender in magnitude and direction. The psychosocial work environment represents a potentially reversible cause of ill health.

Adult↗
PubMed1997

Inequality, deprivation and alcohol use.

There are major social inequalities in health within societies. Alcohol and tobacco are major preventable causes of ill health. Using data from the United Kingdom, this paper examines the social distribution of tobacco and alcohol consumption; the role that tobacco and alcohol may play in mediating or modifying social inequalities in health; and the implications of social distribution for policies to reduce harm associated with consumption of alcohol and tobacco. In the United Kingdom, as in many other countries, there is clear inverse association between socio-economic position and consumption of cigarettes. Over the past three decades, the decline in smoking has been more rapid in men and women in higher socio-economic groups. United Kingdom suggest that among employed men and women, the prevalence of non-drinking shows an inverse association with occupational status; heavy drinking differs little; and moderate drinking is more common among those of higher socio-economic status. Smoking accounts for perhaps 25% of the social class difference in coronary heart disease (CHD) mortality, more for lung cancer, less for some other diseases. healthier patterns of drinking may contribute to the lower CHD rates of higher social classes. Although other factors are clearly important in generating social inequalities, it is important to take the social distribution of alcohol and tobacco into account when formulating policy. For cigarette consumption, there is evidence that in lower socio-economic groups demand is more sensitive to price; higher socio-economic groups are more responsive to health education. There has been less research of this nature for alcohol. Available analyses suggest that price responsiveness of heavy drinking may be greatest in young men and in those with lower incomes. A pricing strategy has important equity implications.

Alcohol Drinking↗
PubMed1997

General explanations for social inequalities in health.

Life expectancy has always differed according to status in society, with a higher mortality among those of lower social status. Although cancer and cardiovascular diseases are more common as causes of death in rich than in poor societies, in industrialized countries the major causes of death are more common in those of lower social status. In this chapter, the magnitude of socioeconomic differences in health is examined using different measures of socioeconomic status, and methodological issues relating to these measures are discussed. Much of the discussion about social inequalities in health has been focused on the health disadvantage of those of lowest socioeconomic status. However, data from the Whitehall studies show that the social gradient in morbidity and mortality exists across employment grades in British civil servants, none of whom is poor by comparison with people in developing countries, suggesting that there are factors that operate across the whole of society. A number of potential explanations are considered here. The magnitude of socioeconomic differences in health varies between societies, and over time within societies. This suggests that identification of factors that influence socioeconomic status and health, and the pathways by which they operate, is an important public health task that could lay the basis for a reduction in inequalities in health.

Adolescent↗
PubMed1996

Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group.

OBJECTIVES: To assess further the relation in Intersalt of 24 hour urinary sodium to blood pressure of individuals and populations, and the difference in blood pressure from young adulthood into middle age. DESIGN: Standardised cross sectional study within and across populations. SETTING: 52 population samples in 32 countries. SUBJECTS: 10,074 men and women aged 20-59. MAIN OUTCOME MEASURES: Association of sodium and blood pressure from within population and cross population multiple linear regression analyses with multivariate correction for regression dilution bias. Relation of sample median daily urinary sodium excretion to difference in blood pressure with age. RESULTS: In within population analyses (n = 10,074), individual 24 hour urinary sodium excretion higher by 100 mmol (for example, 170 v 70 mmol) was associated with systolic/diastolic blood pressure higher on average by 3/0 to 6/3 mm Hg (with and without body mass in analyses). Associations were larger at ages 40-59. In cross population analyses (n = 52), sample median 24 hour sodium excretion higher by 100 mmol was associated with median systolic/diastolic pressure higher on average by 5-7/2-4 mm Hg, and estimated mean difference in systolic/diastolic pressure at age 55 compared with age 25 greater by 10-11/6 mm Hg. CONCLUSIONS: The strong, positive association of urinary sodium with systolic pressure of individuals concurs with Intersalt cross population findings and results of other studies. Higher urinary sodium is also associated with substantially greater differences in blood pressure in middle age compared with young adulthood. These results support recommendations for reduction of high salt intake in populations for prevention and control of adverse blood pressure levels.

Adult↗