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Biomedical subjects

M Markman

Publications and source records attributed to M Markman.

At least 343 records · Page 19Linked to original sources
PubMed1983

Posttransfusion hepatitis in acute nonlymphocytic leukemia: lack of a beneficial influence.

Thirty-five patients with acute nonlymphocytic leukemia (ANNL) entered complete remission (CR) and survived 16 weeks following induction therapy with high-dose timed sequential chemotherapy without maintenance therapy. These patients were analyzed to test the hypothesis that acute posttransfusion hepatitis (APTH) has a beneficial influence on the course of ANNL. Ten patients developed evidence of APTH while 25 did not. Median length of CR was 22 weeks for both groups while median survival was longer in patients not developing APTH (75 weeks vs 58 weeks) (P greater than 0.5). Possible explanations for the discrepancy between these results and those previously reported are discussed.

Acute Disease↗
PubMed1983

Management of hematologic and infectious complications of intensive induction therapy for small cell carcinoma of the lung.

In an effort to improve response rate and survival in small cell carcinoma of the lung, considerable attention has been focused on induction therapy with intensive chemotherapeutic regimens. The morbidity and mortality of such therapeutic programs have been of considerable concern. The hematologic and infectious complications of highly intensive induction chemotherapy in 72 patients with small cell lung cancer treated at the Johns Hopkins Oncology Center were reviewed, and guidelines for the management of aplasia in this patient population are suggested. Bone marrow aplasia was severe, with 90 percent of 140 cycles of therapy associated with the development of fever. However, during only 20 percent of febrile episodes could a specific site of infection or pathogen be identified. Prophylactic platelet transfusions were administered during 42 percent of courses because of severe thrombocytopenia (platelet count below 20,000/mm3). Only a single significant bleeding episode developed during therapy. The occurrence of bacteremia (9.3 percent of cycles) was strongly associated with the development of severe thrombocytopenia. There were no deaths during aplasia. It is concluded that intensive combination chemotherapy can be safely administered to this elderly patient population with acceptable morbidity provided there is strict adherence to the unique principles of antibiotic usage and platelet support during bone marrow aplasia.

Antineoplastic Agents↗
PubMed1983

Irreversible visual loss in Waldenström's macroglobulinaemia.

A patient with Waldenström's macroglobulinaemia presented with visual reduction in both eyes. The funduscopic and angiographic demonstrations of venous engorgement ('string of sausages'), retinal haemorrhages at all levels, retinal and disc oedema, and serous detachment of the maculas were consistent with this diagnosis. The cryoprecipitation of the immunoglobulin at a temperature slightly below body temperature precluded routine blood studies and plasmapheresis. Plasmapheresis was ultimately performed without difficulty with the patient and equipment at 88 degrees F (31 degrees C). Despite marked improvement in the funduscopic and angiographic appearance of the retina, perifoveal capillary nonperfusion and serous elevation of the macula persisted. Even when the maculas flattened in both eyes, no visual recovery occurred. Early diagnosis, even on a clinical basis when laboratory studies cannot be performed, and early plasmapheresis to reduce serum viscosity are warranted to prevent intravascular occlusion in the perifoveal capillary bed, deposition of immunoglobulin in the retina, and transudation in the subretinal space.

Blood Viscosity↗
PubMed1982

Transitional cell carcinoma of the bladder metastatic to the breast.

This report is the first described case of transitional cell carcinoma of the bladder metastatic to the female breast. The patient is a 42-year-old woman who underwent radical cystectomy three months prior to presentation with two asymptomatic right breast masses as the first evidence of widely metastatic bladder carcinoma. The mode of presentation is similar to that seen with other tumors metastatic to the breast and requires the clinician and pathologist to be able to distinguish this diagnosis from primary breast carcinoma.

Adult↗
PubMed1982

Metastatic adenocarcinoma of unknown primary site: analysis of 245 patients seen at The Johns Hopkins Hospital from 1965--1979.

A retrospective review of 245 patient with metastatic adenocarcinomas of unknown primary site (ACUP) seen at The Johns Hopkins Hospital from 1965--1979 was undertaken. The median survival was 3.1 months. Age, sex, race, and year of diagnosis did not appear to influence survival. Patients having their major site(s) of disease above the diaphragm experienced a significantly longer survival than patients whose disease was below the diaphragm (5.3 versus 2.3 months, P less than 0.05). As a group, patients treated with chemotherapy had no improvement in survival. However, the small number of patients treated with either cyclophosphamide or doxorubicin or both drugs had a median survival of greater than 9 months compared to 2.6 months for untreated or local radiotherapy-treated patients and 3.2 months for patients treated with 5-fluorouracil.

Adenocarcinoma↗