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Biomedical subjects

M Markiewicz

Publications and source records attributed to M Markiewicz.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Value of Doppler echocardiography in evaluating pulmonary arterial pressure in patients with mitral valve defect].

In 40 patients aged 25-52 years (mean 36 years) with mitral valve disease but without overt circulatory failure haemodynamic studies and echocardiographic examinations were carried out recording the blood flow in the pulmonary artery and the blood flow through the tricuspid valve by pulsating and continuous-wave methods. From the obtained curves the time was calculated from the beginning of the flow to its maximum (TPV), the pre-ejection time (RPEP) and the right-ventricular ejection time (RVET), and the indices TPV/RVET and RPEP/RVET. Moreover, in 14 patients with coexistent insufficiency of the tricuspid valve the systolic pressure in the pulmonary artery was calculated by determining the systolic gradient across the tricuspid valve. On the basis of the results of haemodynamic examination the patients were divided into two groups: with normal (24 patients) and with raised (16 patients) pressure in the pulmonary artery. In the group of mitral valve disease and pulmonary hypertension a significantly shorter TPV, lower values of the TPV/RVET index and greater values of the RPEP/RVET index were found as compared with the patients with mitral disease and normal value of the systolic arterial pressure in the pulmonary artery. The systolic arterial pressure in the pulmonary artery determined on the basis of Doppler echocardiography with measurement of the regurgitation wave in tricuspid valve insufficiency showed a high agreement (r = 0.94) with the pressure recorded during cardiac catheterization.

Adult↗
PubMed1989

[Value of sustonit in the treatment of patients with stable angina pectoris].

The clinical trial was carried out in 40 men with stable angina receiving for three weeks Sustonit mite or forte. Before and after three weeks of the treatment the exercise test was done on cycle ergometer, followed by echocardiography (for evaluation of left ventricular function) noting also the number of anginal pains and the number of nitroglycerin tablets taken as emergency treatment. In the light of the obtained results it was estimated that Sustonit reduced anginal pains in 82.5% of the patients with stable angina, and exerted a beneficial effect on the left ventricular function as evidenced by increased mean velocity of shortening of the circumferential fibres and reduced number of echocardiograms with segmental contractility disturbances in the ventricular septum and posterior wall of the left ventricle after 3 weeks of treatment. Moreover, Sustoinit treatment increased significantly the amount of work done until reaching of submaximal heart rate and working time during submaximal exercise, as well as the greatest workload necessary for reaching of submaximal heart rate. The drug had no significant effect on the heart and arterial blood pressure. Sustonit mite and forte is regarded as highly valuable and effective drug in the treatment of patients with stable angina.

Adult↗
PubMed1989

[Comparative evaluation of biological availability and anti-arrhythmia effectiveness of Mexicard (mexiletine Polfa)].

In 16 healthy males bioavailability of Mexicord (Polfa) was studied, in comparison with mexiletine of foreign made. Bioavailability extent (EBA) of Mexicord was over 99% in comparison with a standard drug. Comparative study of antiarrhythmic activity and side effects was performed in 32 patients with frequent ventricular premalure beats and nearly in a half of them resistant to antiarrhythmic agents. Mexicord was effective in 47% of treated patients, and side effects (most often nausea) were observed in 28% of patients, but only in 1 case therapy withdrawal was necessary. Statistical study proved a lack of significant differences in antiarrhythmic effectiveness and side effects between Mexicord (Polfa) and a drug of foreign made.

Adult↗
PubMed1989

[Comparative investigation of cardiac output using impedance rheography and invasive methods].

Authors performed comparative measurements of cardiac output using the impedance rheography and Fick's method in healthy men (6) reaching the value of correlation coefficient 0.88 and in patients with acquired cardiac defects (n = 21; r = 0.68). Authors also compared cardiac output values measured at rest and during exercise by means of thermodilution and rheographic methods in patients with heart failure (n = 9). Correlation coefficient was respectively 0.92 and 0.81.

Adult↗
PubMed1989

[Effect of captopril on various components of the kinin system and plasma renin activity in patients with idiopathic arterial hypertension].

Authors studied effect of captopril on serum kininogen and prekallikrein concentrations, as well as on plasma renin activity (PRA) in patients with primary hypertension. The control group consisted of 18 healthy persons, 5 patients were in I, 12 in II and 8 in III WHO class. Monotherapy with 150 mg per day of captopril had been performed for 3 weeks. Patients were 3 times examined: 1--before therapy, 2--after 24 hours of treatment, 3--after 3 weeks of captopril therapy. It was proved, that captopril lowers arterial pressure with coexisting PRA increase and induces changes in kinins system such as: decrease of kininogen+ concentration and increase of serum prekallikrein level in comparison with their pretreatment values. Maximum PRA increase and blood pressure decrease were observed after 24 hours of captopril administration, whereas changes in kinins system were taking place during the whole observation period. Presented studies indicate that antihypertensive action of captopril is related to Renin-Angiotensin-Aldosterone System as well as to plasma kinins one.

Adult↗
PubMed1988

Unknown syndrome: Hirschsprung's disease, microcephaly, and iris coloboma: a new syndrome of defective neuronal migration.

We describe three children with Hirschsprung's disease and microcephaly, two of whom also have an iris coloboma. Two of the children, one with a coloboma and one without, are from the same consanguineous pedigree. The third case is unrelated and was identified by the matching program of the London Dysmorphology Database. This is the first report of this combination of features which are considered to be secondary to defective neuronal migration. An autosomal recessive mode of inheritance is proposed.

Coloboma↗