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Biomedical subjects

M Marcacci

Publications and source records attributed to M Marcacci.

80 records · Page 5Linked to original sources
PubMedDate not supplied

New cell-based technologies in bone and cartilage tissue engineering. I. Bone reconstruction.

A tissue engineering, cell-based therapeutic approach could be essential for extensive bone or cartilage reconstruction. This article is divided in two chapters and describes new cell-based surgical techniques for cartilage and bone reconstruction. In the first part on bone reconstruction, marrow-derived osteogenic progenitor cells combined with hydroxyapatite were utilized. The validity of this model has been shown for the repair of critical size bone defects in large size animal models. We used this cell-based therapeutic approach to treat 3 patients with large bone defects, achieving bone reconstruction.

Adolescent↗
PubMedDate not supplied

New cell-based technologies in bone and cartilage tissue engineering. II. Cartilage regeneration.

A tissue engineering, cell-based therapeutic approach could be essential for extensive bone or cartilage reconstruction. This article is divided in two chapters and describes new cell-based surgical techniques for cartilage and bone reconstruction. The second part of the article, regarding cartilage repair, describes a new arthroscopic surgical technique for tissue engineered cartilage grafting. A 3-dimensional hyaluronic acid support is used for autologous chondrocyte culturing. The technique reduces morbidity of classic autologous implant avoiding open surgery and periosteal flap use. With this technique is possible to reduce the patient morbidity, time and cost of surgery.

Adolescent↗
PubMedDate not supplied

The preliminary results of press-fit knee arthroplasty without a patellar component.

A total of 22 cases of Kinemax prostheses implanted consecutively from January to June 1990 for the treatment of primary gonarthrosis were evaluated; in these cases remodeling of the patella was performed, and the corresponding component of the prosthesis was not used. The mean age of the patients was 64 years, mean follow-up was obtained after 48 months. According to the HSS form results were: excellent: 9 (40.9%); good: 12 (54.5%); fair: 1 (4.6%). The postoperative femorotibial axis measured a mean of 173.8 degrees. There were no complications in the patella, only in 1 case did we observe mild anterior pain. Knee arthroplasty without substitution of the patella seems to guarantee good results in patients with primary gonarthrosis, as long as patellar reconstruction is performed and correct femoropatellar alignment is guaranteed, as well as recovery of the femorotibial axis with accurate positioning of the prosthetic components.

Aged↗
PubMedDate not supplied

Total knee arthroplasty after proximal tibial osteotomy.

The cases of ten total knee arthroplasty after a proximal tibial osteotomy were compared with those of 50 primary total knee arthroplasty for osteoarthritis. The groups were matched according to age of patients, length of follow-up and type of prosthesis used. On the basis of HSS, an excellent or good result was obtained in 90% of patients who had had arthroplasty after osteotomy and in 94% of patients after a primary arthroplasty. Though some intraoperative difficulty may be encountered in a secondary prosthesis, osteotomy does not compromise a subsequent arthroplasty.

Aged↗
PubMedDate not supplied

Age-related changes in human anterior cruciate ligament (ACL) collagen fibrils.

The correlation between anterior cruciate ligament (ACL) collagen fibril diameter and aging were studied in subjects aged 15 to 87 years. The samples processed for light and electron microscopy showed statistically significant differences in collagen fibril diameter among young (< 20 years), adult (20-60) and elderly subjects (> 60 years). In the young, the ACL was made up of collagen fibrils which were highly variable in size (range 20-180 nm); the diameter distribution curve was very asymmetrical (mean asymmetry +0.895). In adults and elderly subjects, the maximum diameter had decreased remarkably (120 and 110 nm, respectively) and the diameter distribution curve had become less asymmetrical (mean asymmetry +0.527 and +0.297 respectively). Fibril concentration increased considerably from young (68 fib/mu 2) and elderly subjects (140 fib/mu 2). This reduction in diameter and the relative change in collagen fibril concentration may be related to changes in elastic stiffness. The increase in small collagen fibrils and the marked rise in their concentration may make the ligament more pliable. These findings are similar to those we obtained in Achilles tendon. They demonstrate that both ACL and Achilles tendon, a tissue which responds to unidirectional mechanical forces more than ACL does, show a reduction in diameter value during ageing. These data further suggest that collagen fibril diameter is related to the aging process.

Achilles Tendon↗