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Biomedical subjects

M Maranesi

Publications and source records attributed to M Maranesi.

35 records · Page 2Linked to original sources
PubMed1984

[Influence of maltitol on lipid metabolism: fatty acid composition of the heart and brain of the rat].

Maltitol is a disaccharide molecule with special physicochemical characteristics due to a glycosidic bond which is not easily split by the natural disaccharidases. This study was designed to investigate possible metabolic consequences of maltitol feeding (replacing one third of carbohydrate quota in the diet) on the lipid metabolism and particularly on the fatty acid composition of rat heart and brain. Result did not show, for group fed with maltitol, significant composition difference. Therefore this glucide can not be considered responsible for metabolic alteration on studied organs.

Animals↗
PubMed1984

Normo and iperlipidic diet influence on fatty acid composition and mitochondrial functionality in rat heart.

This work reports the effect of normo and iperlipidic diets with different fatty acid content on some rat heart mitochondria functionality parameters. Normolipidic assumption according to their fatty acid pattern, affect the mitochondrial structure qualitative aspect but not significantly functionality. An oxidative phosphorylation slowing down is observed on group fed with iperlipidic diets, but not on groups fed with soja phospholipids, where this phenomenon seems to be mitigated.

Animals↗
PubMed1984

Dietary trans-fatty acid effects on mitochondrial functionality and phospholipid composition in rat perfused hearts in oxygenation and anoxia.

Dietary fatty acid fraction influence on heart composition is known and we have previously demonstrated a trans-fatty acid accumulation in heart. In this work we will verify trans-fatty acid effect on heart phospholipid fatty acid composition and miocardic mitochondrial respiratory activity under the influence of perfusion techniques in oxygenation and anoxic conditions. Results have pointed out, in group fed with 28% trans-fatty acid hydrogenated fat, a decreased mitochondrial functionality during perfusion in different oxygenation condition, probably correlated to different fatty acid composition of heart phospholipids.

Animals↗
PubMed1984

Fatty acid composition of single brain structures following different alpha linolenate dietary supplementations.

Weanling female rats randomly divided into three groups were fed a basal alipidic diet added with 10% (w/w) corn oil, soybean oil or linseed oil. After thirty and ninety days of dietary treatment the rats were killed and the fatty acid composition of brain, optic nerve and visual cortex was determined. The results demonstrate a different sensitivity to the diet of the different structures examined and, for the linseed oil treated rats, a strong decrease in the proportions of the total (n-6 + n-3) polyunsaturated fatty acids in all the structures examined.

Animals↗
PubMed1984

Nutritional studies on anti alpha-amylase: I) Influence on the growth rate, blood picture and biochemistry and histological parameters in rats.

Anti-alpha-amylase is a protein characterized by an antienzymatic activity in the sense that it prevents hydrolysis of the alpha--1,4 glycoside bond of starch. Such action could be exploited for reducing the caloric value of the diet. We studied the in-vivo effectiveness of large doses of anti-alpha-amylase extracted from white beans (Phaseolus vulgaris). The growth rate of rats was clearly impaired, the blood pictures and biochemistry showed modifications, and the internal organ histology revealed alterations in the liver and kidney.

Animals↗
PubMed1984

Nutritional studies on anti-alpha-amylase: II) Lipid metabolism investigation: fatty acid composition of organs and tissues.

The effect of dietary anti-alpha-amylase on some aspects of lipid metabolism has been studied after having shown that rats fed proteins from legumes containing anti-alpha-amylase (to cover one-third of the protein quota in the diet) failed to absorb carbohydrates contained in starch to the point that the total caloric intake was sharply reduced and their growth stunted. Upon feeding rats anti-alpha-amylase, destruction of fatty deposits was observed. The animals, on the other hand, did not show evidence of important structural pathology.

Animals↗
PubMed1984

Nutritional studies on Spirulina maxima.

This study was designed to explore the nutritional value of proteins derived from algal biomasses of genus Spirulina maxima, with a view to the possible use of such proteins in human alimentation. Recently the use of such biomasses has commanded attention both as an alternative source of alimentary protein and as a coadjuvant in diet treatment requiring a reduced caloric intake - this because these substances seem to prolong gastric transit time and so produce a feeling of satiety. Our research was conducted in young growing rats; it provided confirmation of the validity of Spirulina as a protein source in terms of good weight gains by the test animals and freedom from adverse effects; the same research, on the other hand, failed to confirm the effectiveness of these protein materials in reducing caloric intake: throughout the test period, indeed, feed consumption (hence caloric intake) was practically the same in the control lot and in animals receiving Spirulina protein.

Animals↗
PubMed1984

Nutritional studies on maltitol. Part 2: Effect on lipid metabolism and fatty acid composition of different rat tissues.

This study has been designed to investigate the possible metabolic consequences of maltitol feeding (replacing 1/3 of the dietary carbohydrates) on the fatty acid composition in various body compartments of the rat. The detailed biochemical analysis of the lipid composition rules out the possible interference of this disaccharide on the lipid metabolism, at least with the dosage and duration of treatment used in the experiment.

Adipose Tissue↗
PubMed1984

Nutritional studies on maltitol. Part 1: Acceptability, energetic yield, effects on growth and blood biochemical parameters.

Maltitol is a disaccharide molecule with special physico-chemical characteristics due to a glycosidic bond which is not easily split by the natural disaccharidases. The present study was designed to evaluate the effects of a prolonged feeding with maltitol on growing rats. Acceptability, caloric yield, intestinal absorption and metabolic effects have been determined.

Animals↗
PubMed1980

Different lipid effects on hematic cholesterol.

Literature fully reports that a polyunsaturated fatty acids suitability reduces cholesterolaemia levels. Many authors regard as very useful for the same purpose phospholipid intakes; certainly this event requires LCAT availability too. In this work we have tried to check EFA, phospholipid and different mixtures of both effects on rat's cholesterolaemia. The research was divided in two tests (3 days long the first, 60 days long the second); the best results for mentioned steroid control, were not proportional as one could suppose, but the effect was positive only for a particular range of mixtures. The achieved results may be explained with an extremely favourable substrata availability, both for quality and amount.

Animals↗
PubMed1979

[Effects of stereochemically different fatty acids on blood cholesterol in rats].

In the present study some observations about the effects of stereochemically different fatty acids on cholesterolaemia are reported. It is well known that high in EFA diets are useful for cholesterol metabolism: in fact cholesterol is preferably esterificated by EFA. Because of the increasing intake of fats, as high in hydrogenated EFA margarines, it has been verified whether such a technological process, inducing structural modifications, affects or not the ipocholesterolemic effect of EFA, particularly linoleic acid. Actually this research has shown such an effect to fail in presence of trans fatty acids and has pointed out some implications of lipid metabolism which are related to the different stereochemical configurations.

Animals↗
PubMedDate not supplied

Effects of short-term dietary administration of marginal levels of vitamin B(6)and fish oil on lipid composition and antioxidant defences in rat tissues.

Previous reports have shown that vitamin B(6)deficiency leads to peroxidative stress in rat organs. In this paper, we evaluated the effects on lipid peroxidation of short-term (six weeks) dietary administration of marginal contents of vitamin B(6). A further risk factor of susceptibility to peroxidation was the presence of fish oil with higher contents of n-3 polyunsaturated fatty acid (LCPUFA). The contemporaneous vitamin B(6)deficiency and presence of fish oil caused a C18:2 increase, a C20:4 decrease, and replacement of some n-6 LCPUFA with n-3 LCPUFA, without changes in the unsaturation index. In liver, TBARS production did not show any differences between dietary conditions, whereas the activities of glutathione-dependent enzymes were stimulated. In heart, fish oil increased lipid peroxidation, especially in the vitamin B(6)-deficient group.

Animals↗