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Biomedical subjects

M Manis

Publications and source records attributed to M Manis.

11 recordsLinked to original sources
PubMed1997

Simultaneous assimilation and contrast effects in judgments of self and others.

Judgments of self and referent others tend to be positively related, as evident in the false consensus effect, but others may also be contrasted from the self, as noted in the false uniqueness literature. In 3 studies that examined the domains of attitudes and traits, evidence of both assimilative and contrastive associations between self- and other-judgements were noted, depending on the form of judgment (objective vs. subjective) and the relevant judgment scale anchor (self vs. others). When self-judgments were made first, objective appraisals of reference groups were contrasted from subjective self-appraisals (after controlling for individual differences in participants' behavioral reports). When judgments of others were made first, objective self-ratings were contrasted from subjective other-judgments. Implications for the false consensus literature and the shifting standards model (M. Biernat, M. Manis, & T. E. Nelson, 1991) are discussed.

Adult↗
PubMed1994

Shifting standards and stereotype-based judgments.

Four studies tested a model of stereotype-based shifts in judgment standards developed by M. Biernat, M. Manis, and T. E. Nelson (1991). The model suggests that subjective judgments of target persons from different social groups may fail to reveal the stereotyped expectations of judges, because they invite the use of different evaluative standards; more "objective" or common rule indicators reduce such standard shifts. The stereotypes that men are more competent than women, women are more verbally able than men, Whites are more verbally able than Blacks, and Blacks are more athletic than Whites were successfully used to demonstrate the shifting standards phenomenon. Several individual-difference measures were also effective in predicting differential susceptibility to standard shifts, and direct evidence was provided that differing comparison standards account for substantial differences in target ratings.

Adolescent↗
PubMed1993

Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid.

The effect of probenecid on glucuronidation of acetaminophen and lorazepam in hepatic microsomes from various species was studied to see if in vitro results were consistent with previous in vivo observations. Mouse, rat, and human microsomes were incubated with acetaminophen and probenecid while monkey microsomes were incubated with lorazepam and probenecid. Glucuronidation rates in all species varied with substrate, protein, and detergent concentrations. Mice exhibited faster rates of glucuronidation than rats or humans. All species showed inhibition of glucuronidation of acetaminophen or lorazepam when probenecid was added. Analysis suggested competitive inhibition. Thus, in vitro studies support in vivo results and confirm that the inhibition takes place at the hepatic level.

Acetaminophen↗
PubMed1993

The illusion of mental health.

It is argued that researchers' reliance on "objective" mental health scales and disregard for clinical judgment has led to many mistaken conclusions. Specifically, standard mental health scales appear unable to distinguish between genuine mental health and the facade or illusion of mental health created by psychological defenses. Evidence is presented indicating that (a) many people who look healthy on standard mental health scales are not psychologically healthy, and (b) illusory mental health (based on defensive denial of distress) has physiological costs and may be a risk factor for medical illness. Clinical judges could distinguish genuine from illusory mental health, whereas "objective" mental health scales could not. The findings call into question the conclusions of many previous studies that rest on standard mental health scales. They suggest new ways of understanding how psychological factors may influence health. Finally, they suggest that clinical methods (which researchers often malign) may have an important role to play in meaningful mental health research.

Adolescent↗
PubMed1991

Comparison and expectancy processes in human judgment.

This work explored a judgment model proposed by Manis and Paskewitz (1984a). The model suggests that prior experience with the members of a given category affects the assessment of other category members in 2 ways: (a) by providing a basis for comparison and (b) by leading the judge to expect that new exemplars will resemble those previously encountered. In 4 experiments, respondents judged the height of different people on the basis of full-length photographs. The height of the models in an induction series constituted the main independent variable. The effects of contrasting inductions (e.g., short vs. tall women) affected the judges' subsequent assessments in a test series. Both comparison and expectancy processes played a significant role, sometimes opposing one another and sometimes acting in parallel (i.e., supporting one another).

Female↗
PubMed1990

Human N-acetylation genotype determination with urinary caffeine metabolites.

The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding a phenyl column, in tandem with a C18 reverse-phase column, by means of a methanol:aqueous acetic acid gradient elution system. The urinary molar ratios of (AAMU)/(AAMU + 1U + 1X) and (AAMU)/(1X) were estimated in 20 subjects phenotyped with dapsone, with 100% concordance for the [AAMU]/[1X] ratio. A population study of 42 unrelated individuals exhibited trimodal distribution in acetylation capacity, consistent with the Hardy-Weinberg theory of population genetics. Definitive pedigree analysis of 16 families (75 subjects) resulted in significant similarity between the observed genotypic matings and those expected by classical Mendelian segregation. This noninvasive genotyping method promises to be useful in future investigation of the relationship between the human acetylation polymorphism and clinical disorders.

Acetylation↗
PubMedDate not supplied

Inhibition of human red blood cell N-acetyltransferase.

Acetanilide and derivatives of benzoic acid, benzamide, salicylic acid, and salicylamide were tested as inhibitors of p-aminobenzoic acid N-acetyltransferase partially purified from peripheral blood of three rapid and two slow dapsone acetylator human volunteers. The 50% inhibition point of these compounds does not provide a kinetic basis for differentiating the rapid and slow dapsone acetylator phenotypes.

4-Aminobenzoic Acid↗