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Biomedical subjects

M Manicatide

Publications and source records attributed to M Manicatide.

35 records · Page 2Linked to original sources
PubMedDate not supplied

Ventilatory impairment and hypoxemia in chronic non-specific lung disease.

The relation between arterial oxygen tension at rest (Pao2) and ventilatory performance (VC and FEV1.0) was studied (198 determinations) in a group of 156 patients (11 females) aged 31 to 76 (mean 52.1) years, with chronic non-specific lung disease (asthmatics non included). The average results were 72.7 mmHg for Pao2, 2.87 1 for VC, 1.32 1 for FEV1.0 and 44.9 % for the FEV1.0/VC ratio. Ninety per cent of the patients had ventilatory impairment (FEV1.0 less than 81 % predicted) and 2/3 had hypoxemia (Pao2 less than 75 mmHg). The Pao2 - spirometric variables linear correlation coefficients were of medium value (0.35 to 0.51), but highly significant due to the large number of observations. The correlation was high in patients with severe ventilatory defect (FEV1.0 less than 40% pred.), weak in those with moderate (FEV1.0 41-60 % pred.) and absent in those with minor or absent ventilatory impairment. In respect to the clinical type of obstructive disease, Pao2 and FEV1.0 showed a high correlation (r=0.69) in "bronchitics", a looser one (r=0.45) in "intermediate" patients, and no correlation for "emphysema" patients. The regression equation relating Pao2 and FEV1.0 (Pao2=64.4 + 5.9 X litres) had too high a standard error of estimate (20 % of the mean) to be of practical value.

Adult↗
PubMedDate not supplied

[Clinico-functional correlations in chronic obstructive bronchopneumopathy: dyspnea and arterial oxygenation].

The severity of dyspnoea was confronted to the value of the partial pressure of arterial oxygen at rest in a group of 51 patients with chronic non-specific pneumopathy associated to medium or severe ventilatory obstruction (VEMS under 1,5 I). The patients have been classified as "predominantly bronchitic" or "predominantly emphysematous" on the basis of clinical, radiological and biological criteria. In the group as a whole there was no relation between the partial pressure of arterial oxygen and the severity of the dyspnoea. The analysis of sub-groups evidenced a tendency to decrease of the oxygen pressure with accentuation of dyspnoea in the "bronchitis" group, although the coefficient value of this inverse correlation did not reach the treshold of statistical significance (r = -0,46; p greater than 0,05).

Adult↗