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Biomedical subjects

M Mandelin

Publications and source records attributed to M Mandelin.

9 recordsLinked to original sources
PubMed1984

A Gemeprost vaginal suppository for cervical priming prior to termination of first trimester pregnancy.

A randomized, double-blind, placebo-controlled, multicentre study was conducted to assess the efficacy and tolerance of a single 1.0 mg Gemeprost (16, 16-dimethyl-trans-delta 2PGE1 methyl ester) vaginal suppository for dilatation of the cervix uteri prior to vacuum aspiration termination of first trimester pregnancy in nulliparous women. The suppository was inserted three hours before vacuum aspiration. In the six centres involved, the preoperative cervical diameter was significantly greater in women treated with Gemeprost. Further mechanical dilatation was either unnecessary or significantly easier than in placebo-treated women. A significant reduction in operative blood loss was noted in the Gemeprost group.

Abortion, Induced↗
PubMed1982

The significance of broadened approach to risk pregnancy.

The appropriateness of widened indications for special surveillance during pregnancy was studied prospectively in a series of 2460 randomly selected mothers. Factors necessitating special care were classified as anamnestic (gr A), those appearing during pregnancy (gr B) or just during labour (gr C). The cumulative contribution of different groups of risk factors to the final risk group of 1811 patients was as follows: gr A 37.0%, gr B 58.4% and gr C 4.6%. Offsprings of mothers with no risk factors had the most favourable prognosis followed by those belonging to groups C, A and B. Maternal risk was clearly highest in the presence of group C factors. Group B factors were recognized by maternal health centre personnel far better than group A factors. The performance of hospital personnel in the observation of different types of risk factors was assessed on the basis of intrapartum monitoring frequencies. The highest monitoring frequency was observed in group O followed by group B, A and C. The results suggest that clearly definable complications of pregnancy and those occurring during labour are easily observed and their management is adequate. Anamnestic risk factors which are more obscure by definition and especially by mechanism of action tend to escape the attention of medical personal. Fortunately these factors alone contributed only an insignificant proportion of adverse outcomes in the mother and child.

Attitude of Health Personnel↗
PubMed1979

Menstrual regulation as a method for early termination of pregnancy.

116 women with documented or suspected pregnancy underwent an endometrial aspiration for early termination. Their menses delay was between 7 and 22 days. A standard 3 mm Vabra aspirator was used. 90.5% were actually pregnant. The success rate was 97.1%. The total complication rate was 6.8%, the most common complication being endometritis. Three patients required a re-evacuation because of prolonged bleeding. In this series there were two ectopic pregnancies and nine cases of ovum abortivum, of which one later turned out to be a hydatiform mole. The procedure was well tolerated by the patients. No sick-leave was given. The postoperative bleeding averaged 10 days in primigravid and 7 days in parous patients.

Abortion, Induced↗
PubMed1979

Pregnancy outcome after previous induced abortion.

The outcome of pregnancy was studied in 325 patients with an induced abortion in their previous pregnancy, together with 721 control patients. The patients were matched for age, parity and social class. Smoking and unplanned pregnancies were found to be more comon among abortion patients than among the control patients. As regards pregnancy complications, bleeding during pregnancy and placental retention were found to be significantly more common in the index group. No statistical differences were noticed in gestation length, birthweight, rate of spontaneous abortion and perinatal mortality in the pregnancy following induced abortion as compared with control patients.

Abortion, Induced↗
PubMed1978

Induction of second trimester abortion: comparison between vaginal 15-methyl-PGF2alpha methyl ester and intra-amniotic PGF2alpha.

The efficiency and acceptability of a single-dose, long-acting vaginal suppository containing 3.0 mg of 15-methyl PGF2alpha methyl ester was compared with intra-amniotic administration of 50 mg of PGF2alpha in 100 patients with a second trimester pregnancy termination. Within 24 hours, 78 per cent of the patients in the vaginal group and 92 per cent in the intra-amniotic group had aborted. The mean induction-abortion interval was 17.9 hours in the vaginal group and 15.8 hours in the intra-amniotic group. Gastrointestinal side-effects were more frequent, but the procedure was less painful, with vaginal 15-methyl PGF2alpha methyl ester than with intra-amniotic PGF2alpha. The vaginal route is technically simple for adaptation to large-scale use, but the high frequency of gastrointestinal side-effects still limits the acceptability of 15-methyl PGF2alpha methyl ester in vaginal administration.

Abortion, Induced↗
PubMed1978

Termination of early pregnancy by a single-dose 3.0 mg 15-methyl PGF2alpha methyl ester vaginal suppository.

The abortifacient effect of a single-dose, long-acting vaginal suppository containing 3.0 mg of 15-methyl PGF2 alpha methyl ester was investigated in 104 early pregnancies. The pregnancy was terminated in 91 per cent of the cases. The abortion was uncomplicated in 79 patients, while 12 patients experienced prolonged bleeding. In 21 uncomplicated cases, VabraR curettage done 4 weeks after therapy revealed necrotic residual tissue in 16 patients and nonspecific endometritis in 20 patients. Residual tissue was found in about 50 per cent of the patients curettaged after 1st menstruation, but no residua was found after 2nd menstruation. In patients with prolonged bleeding, substantial amounts of necrotic residual tissue was found in all patients curettaged 4 weeks after therapy. The decline of serum hCg and plasma progesterone levels was significantly slower in these patients as compared with uneventful abortions.

Abortifacient Agents↗