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Biomedical subjects

M Mancuso

Publications and source records attributed to M Mancuso.

At least 109 records · Page 6Linked to original sources

[Immuno-oncologic monitoring of patients with bronchial carcinoma. I. Carcinoembryonic antigen (CEA)].

Plasma levels of carcinoembryonic antigen (CEA) were determined in 82 lung cancer patients before surgery and during the clinical course of the disease. Results were compared to those obtained in normal controls and in patients with lung inflammatory diseases. Furthermore, relationships between plasma CEA levels and survival were carried out. While CEA levels were not useful to make differential diagnosis, in our study, we hypothized the possibility to use CEA in prognostic evaluations.

Bronchial Diseases↗

Proximal arteriovenous fistulas for vascular access in periodic hemodialysis.

Six proximal arteriovenous fistulas were created in 6 uremic patients on periodic hemodialysis, in whom previous distal shunts or the interposition of heterologous materials had failed. The operations were performed with the vascularization of the upper limbs and a cutaneous incision at the bend of the arm. All patients were women. All the arteriovenous fistulas showed good functioning at the end of the procedure and follow-up from 0 to 45 months.

Adult↗

[Medical complications in lung resections].

The complications of pulmonary resections are discussed with reference to a group of 82 patients. Arrhythmias, infections of pleural space and post-operative atelectasis occur with major frequency. Pleuropulmonary infections are most serious events because they are associated with significant mortality.

Adenocarcinoma↗

[Evaluation of leukocyte migration inhibition (LIF) in patients with carcinoma of the lung before and after the use of levamisole in vitro].

Aspecific immunosuppression in neoplasia has long been known, even though all its biological aspects are not yet fully understood. Inhibition of leukocyte migration (LIF) was studied before and after the use of levamisole in vitro to determine whether changes occurred in cell reactivity. The results of the investigation are discussed in the light of modern immunopathological theories.

Humans↗

[Castleman's tumor. Considerations on 3 operated cases].

Three recently observed cases of Castleman's tumour are described. A brief summary of the clinical histories, themselves of little significance, the histological, diagnostic and therapeutic aspects of the disease are examined. The series is shown to be fully in line with those reported in the literature, and support is given to the view that the tumour is of inflammatory origin.

Adult↗

[Solitary plasmocytoma of the lung. Anatomo-clinical considerations on a case].

A case of solitary plasmacytoma of the lung is presented. The patient is still alive three years after surgery. The anatomical and clinical features of this rare form are discussed. Stress is laid on the fact that diagnostic certainty can only be obtained immunopathologically. It is also recommended that patients be subjected to radiological and laboratory examination in the postoperative period, and every six months for several years, to detect the possible occurrence of multiple myeloma.

Aged↗

Echocardiographic diagnosis of subacute bacterial endocarditis.

The echocardiogram is able to diagnose on which valvular leaflet or cusp the bacterial vegetations are implanted; it is also able to recognize the type of lesion (destroying vegetations, prolapsing vegetations, etc.). In our experience the echocardiographi findings were fully confirmed at surgical intervention in 12 of the 13 patients studied.

Adult↗

[Prognostic elements in bronchial carcinoma].

In spite of improvements in diagnosis and treatment, the fatal prognosis of lung cancer has persisted over the course of 25 years in a series of nearly 4000 patients. Only 30% (1149 cases) were operable, and on 23% of those resected (i.e. 7% of the total) survived for 5 years. An assessment is made of the relationship between survival and sex, age, tumour size and site, radiological picture, stage of invasiveness, type of surgery and degree of radicality, histological picture, and number of circulating lymphocytes. Age, sex and the type of resection (lobectomy or pneumonectomy) had no relation to prognosis. Palliative surgery was always associated with a fatal prognosis, as were cases with invasion of the chest wall, or, more particularly, with oat cell cancers. The outlook was more favourable in cases where radical treatment was given, in cases of squamous cancer, as opposed to other histological types, in those in stage 1 (Am. Joint Committee classification), and those with greater than 2000/mm3 lymphocytes--especially in adenocarcinomas.

Humans↗

[Post-extrasystolic potentiation for the study of regional left ventricular asynergy (author's transl)].

In 120 P. with ischemic heart disease, left ventricolar wall motion was analyzed from the left ventriculogram in a regular sinus beat as compared to the first beat following one or more premature ventricular contractions (PExP). The response of asynergic segment to PExP was determined with a qualitative as wall as a quantitative technique. Of a total of 225 asynergic segments, 62% showed a positive response to PExP. In the absence of pathologic Q waves in the electrocardiogram, the response was positive in 77% and negative in 23% of the cases. In the presence of Q waves, PExP was present only in 33% of the cases (p less than 0.001). In respect to the severity of asynergy, 68% of 145 hypokinetic segments and 52% of 80 akinetic-dyskinetic segments responded to PExP; in the presence of pathologic Q waves, the number of positive responses decreased to 36% in the case of segmental hypokinesis, and to 31% in the case of more severe asynergy. The study of PExP has appeared as an useful diagnostic technique, capable of detecting a residual myocardial function in left ventricular asynergic segments, even in the presence of electrocardiographic signs of infarction.

Adult↗