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Biomedical subjects

M Mall-Haefeli

Publications and source records attributed to M Mall-Haefeli.

At least 19 recordsLinked to original sources
PubMed1979

[Comparative clinical investigation of oral contraceptives with different doses (author's transl)].

The investigation of four oral contraceptives with different doses in adolescent girls showed that bleeding disturbances occur more frequently with low-dose preparations at the beginning of treatment. Nevertheless, these disturbances should be considered indicative of lesser central suppression. For this reason adolescent girls -- especially those with still immature cycles -- should be treated chiefly with preparations having only a low inhibitory effect on the central endocrine system in order not to disturb the maturation of the cycle.

Adolescent↗
PubMed1979

[Comparative catamnestic investigations concerning the psychological effects of sterilisation (author's transl)].

In a comparative catamnestic study the emotional working-through of sterilisation in 3 groups of 33 women was examined (duration of catamnesis: 10-12, 5, 2 years). Whereas in all the 3 collectives the upper lower class (according to Bolte) is represented the most frequently (58% in the 1st and the 2nd, 52% in the 3rd), as far as the lower middle class is concerned there is a higher fraction in the 3rd collective (p less than 0,05) and of the middle class there is a higher fraction in the collectives 1 and 2 (p less than 0,05). Women with a higher income (p less than 0,01) and with a better school and professional (p less than 0,05) training are overrepresented in the 2nd and 3rd collective. In the 3rd group only 6% indicated a religious bond, in comparison to 55% in the 1st and 49% in the 2nd group (p less than 0,01). Women of the 2nd and the 3rd collective were in comparison to those of the 1st group older (p less than 0,01) when they were sterilised, and had less children (p less than 0,05-0,01). In the 3rd group there were more divorced women (18%) in comparison to 3% in the 2nd and 0% in the 1st group (p less than 0,01). Concerning the indication for sterilisation medical-psychiatric causes were preponderant with 42% in the 1st group in comparison to 24% in the 2nd and 18% in the 3rd group (p less than 0,01), whereas in the 2nd group (61%) the social indications were predominant. The immediate cause for sterilisation was represented in the 2nd and the 3rd collective preponderantly by the desire to replace the hormonal contraceptives (p less than 0,01). The 1st collective mainly used insecure contraceptive methods before the operation, the 2nd and 3rd principally hormonal methods (p less than 0,01). In the 1st group it was mainly the insecurity of the method, in the 2nd and the 3rd there were more frequent side effects or contraindications (p less than 0,01), which caused the dissatisfaction with the anticonceptive method. The 3 groups differed significantly concerning the catamnestic evaluation of sterilisation. 100% of the last, 94% each of the 2nd and 3rd were satisfied concerning the sterilisation. To the question of working-through of sterilisation concerning psychic, somatic and especially sexual effects, most of the women in all the 3 groups responded favourably.

Adult↗
PubMed1977

Morphologic alterations in the epithelium of the human oviduct induced by a low dosis gestagen.

Morphological alterations in the epithelium of the human oviduct related to continuous administration of low dosage lynestrenol were studied in 10 women by electron microscopy. The effect of lynestrenol on the morphology of the tubal epithelium was shown to be time dependent. First the discharge of secretory products from the non-ciliated cells was inhibited. Secondary to this the synthetic activities of the cells were drastically decreased. This inactivation of the tubal epithelium reached its maximum after 6 months. At this time the epithelial cells, particularly the non-ciliated cells were almost devoid of organelles and had an electron transparent cytoplasm. In addition to the action of lynestrenol on the secretory and synthetic activities of the cells a strong ciliogenetic effect could be observed after about 3 months of lynestrenol administration. The ratio of ciliated to non-ciliated cells changed from 1:1 at the beginning of the treatment to 2.9:1 after 6 months. This ratio was then maintained and could still be found in patients who had used lynestrenol for 25 and 39 months. In contrast to the persistent effect of lynestrenol on the ciliary apparatus of the cells the synthetic activities and the secretory mechanism were partially restored with long standing use. The importance of the observed changes and their possible participation in the contraceptive action of lynestrenol are discussed.

Adolescent↗
PubMed1976

[The low dosis gestagen therapy (author's transl)].

In young women aged 22-34 years the hormone profile under continuous therapy with 0.5 mg lynestrenol/day have been investigated. Estradiol, progesterone and FSH values have been determined in plasma by the RIA or protein-binding method, whereas LH excretion was daily measured in the urine starting on the 5th day of cycle. The low-dose-gestagen therapy shows all possible hormonal patterns ranging from the ovulatory to anovulatory one. The estradiol-17 B values in half of the patients were higher than in the cycle preceding treatment. In the first few treatment cycles all women showed markedly decreased progesterone values. However, this defect seems to recover and return to normal in later cycles. In order to be able to further explain the alterations occurring during the luteal phase under the treatment with 0.5 mg/day of lynestrenol, ovarian tissues wedge resection of women undergoing gynecological surgery has been examined macroscopically and microscopically. At the same time the hormonal profile has been determined in plasma. These investigations revealed that the morphological alterations in the ovary proceed in an unchanged way under the mentioned treatment. Histologically it could be demonstrated that ovulation is delayed by several days. The histological findings of tubal tissue (from patients who underwent sterilization) showed that the secretional activity of the tubal epithelium is considerably decreased and ciliogenesis increased. In our clinical study neither tablet nor patient failures occurred. With the exception of cycle- and tempo-disturbances no severe adverse reactions were reported. Breakthrough bleedings and spotting as well as amenorrhea in most cases manifested already in the first treatment cycles. It is important that the daily tablet is taken at midday because the maximum effect on the cervical mucus of the mini-pill therapy is most pronounced 4-6 hours after tablet intake. Especially in young patients it is recommended to get written reports on tablet intake. The strict following of these directions mainly guarantees a successful mini-pill therapy.

Adult↗