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Biomedical subjects

M Malinowska

Publications and source records attributed to M Malinowska.

14 recordsLinked to original sources
PubMed1999

[The range of antagonistic effects of Lactobacillus bacterial strains on etiologic agents of bacterial vaginosis].

Bacterial vaginosis is caused by uncontrolled sequential overgrowth of some anaerobic bacteria: Gardnerella vaginalis, Prevotella bivia, Bacteroides spp., Peptostreptococcus spp., Mobiluncus sp. usually occurring in stable numbers in the bacterial flora of healthy women. On the other hand, different species of bacteria belonging to the genus Lactobacillus, most frequently L. plantarum, L. rhamnosus and L. acidophilus, form a group of aerobic bacteria dominating in the same environment. The diversity and density of their populations depend on the age and health conditions. Thanks to their antagonistic and adherence properties bacteria of the genus Lactobacillus can maintain a positive balance role in this ecosystem. The aim of this study was to assess the antagonistic properties of Lactobacillus strains isolated from the vagina of healthy women against most common agents of bacterial vaginosis. It was found that nearly all of the tested Lactobacillus strains exerted distinct antagonistic activity against anaerobic bacteria: Gardnerella vaginalis, Prevotella bivia and Peptostreptococcus anaerobius and quite a number also against Gram-negative rods, while only some of them were able to inhibit Gram-positive aerobic cocci as Enterococcus faecalis or Staphylococcus aureus.

Bacteria, Anaerobic↗
PubMed1997

Thalamic and amygdaloid connections of the auditory association cortex of the superior temporal gyrus in rhesus monkey (Macaca mulatta).

Thalamic and amygdaloid connections of three association auditory areas (AA1, AA2, AA3) of the superior temporal gyrus (STG) were investigated. In order to define the projections of the particular areas, injections of fluorescent tracers were made in three monkeys. Distribution of labeling indicates that area AA1 differs from areas AA2 and AA3 in patterns of both thalamo-cortical and amygdalo-cortical connections. Area AA1 receives its predominant inputs from the ventral and dorsal nuclei of the medical geniculate body (MGB). The amygdaloid projection to the area AA1 originates from the basal nuclei, whereas input from the lateral nucleus was not found. The characteristic thalamic projections to areas AA2 and AA3 originate from the dorsal MGB nucleus and the polymodal nuclei of the posterior thalamus. The density of projections from the dorsal nucleus gradually decreases from area AA1 to area AA3 while projections from the Plm, Sg and Lim nuclei increase in the same direction. Areas AA2 and AA3 are the source of strong connections with the lateral nucleus of amygdala, which density increases progressively when injections shift from area AA2 to AA3. The basal and accessory basal nuclei are the source of a less significant amygdalofugal projections to both cortical areas. Thus, our experimental data indicate that influence of the polymodal thalamic nuclei increases substantially in the direction of the higher order association areas. The strong relation of the same cortical areas with the lateral amygdaloid nucleus might suggest that areas AA2 and AA3, in addition to auditory input are the site of transfer of complex sensory information to the amygdala.

Amygdala↗
PubMed1997

Diversity of connections of the temporal neocortex with amygdaloid nuclei in the dog (Canis familiaris).

Reciprocal connections of amygdaloid nuclei with the temporal neocortex in the dog were investigated. Injections of fluorescent tracers and BDA into particular temporal areas were made in eleven dogs. The topographical arrangement of connections and variations in their density differentiate the temporal neocortex in the dog into a few regions. Among them, the cortex involving the anterior part of the ectosylvian gyrus did not send any amygdalopetal projection. The middle ectosylvian, dorsal zone of the posterior ectosylvian and the anterior part of the Sylvian gyrus were weakly connected with the amygdala. The cortical region involving the ventral zone of the posterior ectosylvian and composite posterior areas, as well as posterior Sylvian gyrus, was characterized by profuse connections with the amygdaloid complex. Cortico-amygdaloid connections originate in the wide cortical area of the auditory cortex of the middle and dorsal part of the posterior ectosylvian gyrus as well as in the auditory association cortex located in the ventral ectosylvian, composite posterior and posterior Sylvian gyri. The connections showed a dorso-ventral gradient of increasing density, in the direction of association fields. The most substantial projection taking rise from the ectosylvian posterior and posterior composite gyri terminated preferentially in the pericapsular sector of the lateral amygdaloid nucleus and, to a lesser degree, in its medial sector. Terminals of connections originating in the Sylvian gyrus occupied preferentially the intermediate part of the lateral nucleus, slightly more medially than that from the ectosylvian and posterior composite areas. Additionally, axonal terminals derived from the composite posterior and Sylvian posterior areas were observed in the basal parvocellular and magnocellular nuclei. Neocortical projections were reciprocated by amygdalofugal connections with two exceptions: the basal magnocellular nucleus was distinguished by a substantial amygdalofugal projection to the temporal neocortex focused on the dorsal Sylvian gyrus, and the central nucleus of the amygdala, in contrast, received an exclusively corticofugal projection.

Amygdala↗
PubMed1989

Augmented breath provoked by lung inflation in cat.

The rate of occurrence and magnitude of provoked augmented breath (PAB) were studied as the function of lung expansion applied at different intervals (15-180 s). Together with phrenic nerve activity (Phr.) the activities of recurrent laryngeal (RL) and hypoglossal (Hyp) nerves were investigated during PAB. The experiments were carried out in 10 cats anesthetised, paralysed and artificially ventilated by means of a phrenic nerve-driven respiratory. Lung expansion was performed by increasing the gain of the servorespirator for one breath. PAB could be elicited when the interval between subsequent inflations was longer than 30 s ("refractory time"). We did not find out any consistent relationship, common for all experiments, between the value of the interval (greater than 30 s) and the rate of occurrence of PAB as well as between the volume of lung inflation and the magnitude of PAB. During PAB registered on Phr., activities of RL and Hyp were usually inhibited. It is concluded that PAB depends upon the instantaneous balance of excitatory and inhibitory vagal influences centrally differentiated at various respiratory outputs. Its amplitude and occurrences are therefore difficult to predict. Thus, PAB can be hardly compared with spontaneous deep breath.

Animals↗
PubMed1979

Oxidative and demethylating activity of multiple forms of laccase from Pholiota mutabilis.

1. The inducible and constitutive forms of laccase from the fungus Pholiota mutabilis show both the oxidative and demethylating activity, which proves the bifunctional character of the enzyme. 2. The oxidative/demethylating activity ratio of the forms induced either with ferulic or syringic acid is different from that shown by the constitutive form. 3. Splitting of one methoxyl group from the methoxyphenol substrate is associated with the release of one molecule of methanol.

Agaricales↗
PubMedDate not supplied

Effect of inderal on insulin secretion, glycemia and FFA concentration in normal subjects and diabetics.

In 20 cases of adult-type diabetes and in 10 healthy controls insulinemia, glycemia and free acids concentration were determined under basal conditions, after glucose load and after administration of inderal and glucose. After intravenous injection of inderal basal insulinemia fell in controls but this fall was statistically not significant, while in diabetics no evident changes of insulinemia were observed. Following inderal injection and oral glucose a statistically significant drop in insulinemia was observed in controls but not in diabetics. In both groups inderal injection was without any significant effect on glycemia before as well as after glucose load. In both groups a significant decrease occurred in the level of free fatty acids and inderal had no effect on it.

Adult↗