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Biomedical subjects

M Makek

Publications and source records attributed to M Makek.

At least 55 records · Page 3Linked to original sources
PubMed1982

Malignant fibrous histiocytoma arising in a recurrent chordoma. Case report and electron microscopic findings.

We present the case of a sacrococcygeal chordoma which recurred 15 years after the radical removal as a soft tissue tumor in the gluteal musculature. This tumor consisted of two parts: a chordoma without symptoms of aggressive cellular proliferation and a malignant fibrous histiocytoma. During the following 4 years several local recurrences of the malignant fibrous histiocytoma occurred in the gluteal musculature. The patient finally died of lung metastases. No chordoma tumor tissue was found in the lungs, in the gluteal musculature or in the sacrococcygeal bone area. Histology including electron microscopy revealed no proof of a transition of chordoma into malignant fibrous histiocytoma. It must be assumed that the secondary soft tissue tumor originated from residual chordoma cells which were implanted during the operation of the primary tumor. It remains unclear whether the malignant fibrous histiocytoma arose from mesenchymal stromal cells within the chordoma or directly from primitive neuroectodermal chorda cells which possess the ability to differentiate into a variety of cell types including mesenchymal cells.

Chordoma↗
PubMed1980

Pleomorphic adenoma of the human breast.

Pleomorphic adenomas of the human breast are histologically identical to those of salivary glands. To date, the literature reports but 15 such benign tumors, all of which occurred in women. The present paper describes clinical and pathologic findings in three further cases, including one man. Considered together, unnecessary mastectomy occurred in 44.4%, indicating the importance of separating this benign entity from malignancies with stromal metaplasia. In case of examination by frozen section, a peripheral portion, if not the entire tumor, should be submitted to the pathologist.

Adult↗
PubMed1980

Non ossifying fibroma of the mandible. A common lesion with unusual location.

A first case of non-ossifying fibroma located in the mandibular condyle of a 20-year-old male is presented. Radiologic and histologic findings correspond in all details to those of non-ossifying fibromas of long tubular bones. The lesion's location within the condylar growth zone may strengthen the hypothesis that non-ossifying fibromas are disturbances in growth rather than true neoplasms.

Adult↗
PubMed1980

Eosinophilic granuloma of the mandibular condyle. Case report.

A case of eosinophilic granuloma of the mandibular condyle in a 38-year-old woman is reported. Clinically, the lesion presented as a malignant process with pathological fracture. The problems related to radiographic and histological diagnosis are discussed.

Adult↗
PubMed1980

[Malacoplakia of the prostate].

A case of malacoplakia of the prostate in a 66-year old man is reported. This is the first time, that the diagnosis was established by needle biopsy. There are only eight previous reports of prostatic involvement. Three of these cases were initially misinterpreted as carcinoma. The present case is discussed in view of the pertinent clinical and pathological data in the literature.

Aged↗
PubMed1980

[Idiopathic nodular calcinosis of the scrotum (author's transl)].

We report two new cases of rare idiopathic nodular calcinosis of the scrotum, which is characterized by intracutaneous chalky deposits restricted to the scrotum in otherwise healthy young men. Diagnosis has to be made histologically. Therapy consists of local excision.

Adult↗
PubMed1978

Localized nodular synovitis of the temporomandibular joint. A case report.

A case of localized nodular synovitis of the temporomandibular joint is described and discussed. There are no cases previously reported in the literature. The distinction between synovitis of the villo-nodular type and that of the localized nodular type can be made, given the close collaboration of clinician and pathologist. The recognition of these to clinical entities of nearly similar histomorphological pattern is of great importance, as they differ in clinical course, treatment and prognosis.

Diagnosis, Differential↗
PubMed1977

[Monostotic fibrous dysplasia of the ribs].

The clinical features, macroscopic and radiologic findings and typical histologic alterations in three cases of fibrous dysplasia of ribs are described. In one case the lesion presented as a tumor-like growth of a size unprecedented in previously reported cases. In differentiating this condition from ossifying fibroma, the pattern of distribution of newly formed bone to fibrous connective tissue is shown to be a valuable criterion. In fibrous dysplasia this ratio is constant for any given area, but varies considerably in ossifying fibroma.

Adult↗
PubMedDate not supplied

Pathogenesis and surgical treatment of migraine and neurovascular headaches with rhinogenic trigger.

Patients (299) with various types of headaches (migraines, cluster headaches, and so-called idiopathic headaches) were operated on between 1973 and 1991. Septal correction, resection of the middle concha, ethmoidectomy, and sphenoidectomy on the corresponding headache side or occasionally on both sides were carried out. Most patients (235; 78.5%) were totally asymptomatic postoperatively; 34 (11.5%) had a sensation of pressure in the head on rare occasions but no further migraines, and 30 (11%) continued to experience headaches that occurred only rarely and were mild and of short duration.

Ethmoid Sinus↗
PubMedDate not supplied

[Distant metastases and second carcinomas in patients with malignancies of the oral cavity].

Between July 1st, 1984, and December 12th, 1988, a total of 135 patients underwent surgery for carcinomas of the oral cavity at the Maxillofacial Surgery Department and the Institute for Pathology of the University Hospital of Zürich. In 121 cases the malignancies involved the mandibular area including the floor of the mouth and the tongue, in 14 cases the maxillary area without the sinuses. 18 patients (13.3) had distant metastases and 8 patients (5.9%) had second carcinomas; 2 patients had both second carcinomas and metastases of their oral cavity carcinomas. The average age of the patients with distant metastases was 57.8 years, that of patients with second carcinomas 52.2 years. Diagnosis, treatment and the course of the disease are discussed.

Aged↗
PubMedDate not supplied

[Osseous metastases in upper and lower jaws].

18 cases of metastases to the jaws in the last 10 years obtained from the Clinic of Maxillofacial Surgery and the Department of Pathology, University Hospital Zürich, are described. They were seen in patients with carcinoma of the breast, lung, prostate gland, uterus and seminoma of the testis. In 16 cases the metastases were situated in the mandible, in 2 cases in the maxilla. The average age of these patients was 61.6 years with no sex predilection. The initial symptoms were pain swelling. In 4 cases a pathologic fracture was diagnosed. The majority of the metastatic lesions are osteolytic in nature. The metastases were diagnosed, in average 3.3 years after diagnoses of the preliminary tumor. In 2 cases the metastases were diagnosed before the occult primary tumor. Death usually ensues 1 year after diagnoses.

Adenocarcinoma↗