Out of 12 oximes and amidoximes (3 of which were new to the literature) the following showed a distinct antilethal effect in DFP poisoning: RA14 (1-methylbenzimidazole-2-aldoxime methiodide), RA14 (pyridine-4-aldoxime dodecyl bromide), and RA24 (pyridine-2-aldoxime dodecyl bromide). These compounds also reactivated acetylcholinesterase (AChE) in vitro, but had no effect on this enzyme in vivo. Moreover, addition of the dodecyl chain to pyridinealdoxtimes, or in a less degree replacement of the pyridine ring with benzimidazole in aldoximes, distinctly increased acute toxicity and lipophilicity when compared with the parent pyridine compounds, along with protective action in DFP poisoning.

Acetylcholinesterase↗

PubMedDate not supplied

[Preliminary results after multiple knee injuries with operative reconstruction of chronic posterior-lateral instabilities].

AIM: The operative treatment of posterior knee instability is a difficult problem and the literature does not offer methods as good as ACL reconstruction. METHODS: With a new operative approach the authors have attempted to improve the surgical procedure and the final outcome in terms of stability and function. To illustrate our clinical findings, 20 cases of chronic posterior-lateral knee instability were retrospectively reviewed following PCL reconstruction. We examined 5 women and 15 men. The average follow-up period was 14 months (6 - 24 months) and the average age was 30 (17 - 59) years. RESULTS: Subjectively all patients were satisfied with the surgical outcome and there were no intraoperative technical difficulties and no patient had a postoperative problem. The p.-a. instability measured at 20 degrees of knee flexion was preoperatively 11.7 mm, postoperatively 7.2 mm and 6.7 mm on the uninjured side. The Lysholm score was preoperatively 59 (35 - 71) points and postoperatively 85 (65 - 100) points. 19 patients returned to work and 14 patients were able to participate in sports. CONCLUSION: The results demonstrate that the knee still does not have a normal stability postoperatively, but the results were reproducible and the method appears to be reliable.

Adolescent↗

PubMedDate not supplied

[Radiological changes caused by osteitis in infancy].

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Adult↗