Biomedical subjects
Publications and source records attributed to M Mailloux.
Human leptospiroses in the island of Reunion have a common point: they are severe diseases. Approximately 50 to 60 cases are biologically diagnosed every year. The number of cases is correlated with rainfall. The predominating serogroup is Icterohaemorrhagiae, followed by Canicola, Grippotyphosa and Australis.
Bovine leptospirosis is a typical form in the island of Reunion. It appears during the second part of the rain season. The clinical picture of equine leptospirosis is acute hepatonephritis. About 10 serogroups are found in bovines, with greater frequency for Sejroë and Hebdomadis. In horses, the prevailing serogroups are Autumnalis, Ballum, Icterohaemorrhagiae, Australis, Grippotyphosa.
In the island of Reunion, rodents and wild dogs can be carriers of leptospires. Aquatic environmental plays an important part. Human contamination is associated with water and sugar cane. Animals are infected by numerous serogroups.
Leptospiroses in Morocco have been studied from 1979 to 1981. In man, L. icterohaemorrhagiae is the most frequently diagnosed serotype. The highest incidence of positive diagnoses is found in Fès-Meknès area. Leptospirosis is a severe disease: 1 out of 3 patients is hospitalized in Intensive Care Unit. Rat is an essential carrier of germs in Casablanca.
This first study about human leptospiroses in New Caledonia reports 32 cases diagnosed between 1973 and 1980. They are typical forms with hepatonephritis in 90 % of cases. Serogroup Icterohaemorrhagiae is predominating (75 %), followed by Canicola and Australis. The disease is spread throughout the whole territory with two foci in the suburbs of the main town where there are irrigated market gardens. Contamination is indirect by contact with water infected by rodents.
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Occupational groups are divided into two groups: 1. Direct contact with animals (14 per cent): veterinary work, hunting, slaughtering, butchers and pork-butchers' work. 2. Contact with natural environment. Transmission is indirect, through water, aquatic environment: stall-keepers, drivers dealing with dumping grounds, scavengers, persons working underground, in cellars, sewers, and particularly agricultural workers, market-gardeners, cattle raisers; bathers and anglers who have direct contact with water. This mode of transmission: rural areas, agriculture, is recorded in 38 per cent of the cases. Contamination through water represents 27 per cent. Leptospiral diseases occur in 4/5 of the cases when Man is in contact with Nature. In most cases, 86 per cent, Leptospirosis is an environmental disease caused by wet ground, aquatic environment.
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The authors show the existence of a TR (thermoresistant) antigen capable to withstand heating at 100 degrees C for 30 minutes. This antigen is present in Patoc I, serogroup Semaranga. It absorbs the corresponding immune serum at rates exceeding 99%, and appears to be the only antigen playing a part in the absorption of agglutinins. The existence of a TR antigen was demonstrated in various pathogenic serotypes. This antigen withstands heating at 80 degrees C for 10 minutes. The TR antigen absorbs antibodies of immune sera of the corresponding strains; and, in cross agglutination reactions, antibodies of the other immune sera of the studied pathogenic leptospires. the TR antigen of serotypes icterohaemorrhagiae Wijnberg, australis Ballico and pyrogenes Salinem are not able to absorb agglutinins of sera anti-Patoc I, whereas TR/Hebdomadis and TR/Pomona absorb as much as 20%. tr/hond Utrecht IV and TR/Patoc I (by absorbing their immune sera in cross agglutination) act as homologous strains with an absorption rate of 99%. The capability of absorption of TR changes according to the composition of culture media. This antigen, heated at 80 degrees C for 10 minutes and obtained pyrogenes Salinem is used for macroscopic diagnosis in slide test procedure by mixing equal proportions of antigen and serum. A positive reaction is indicated by distinct agglutination clumps.
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