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Biomedical subjects

M Maalej

Publications and source records attributed to M Maalej.

At least 55 records · Page 3Linked to original sources
PubMed1991

Selective homing of phenotypically lytic cells within nasopharyngeal carcinoma biopsies: numerous CD8- and CD16-positive cells in the tumor.

We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and tumor-infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8- and CD16-positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T-lymphocytes expressing HLA-DR molecules and IL-2 receptors. Functionally, TIL exhibit an abolished NK-cell activity and concomitant decrease of proliferative response to phytohemagglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL.

Antigens, CD↗
PubMed1990

[Intraorbital involvement in multiple myeloma].

According to data from the literature, intraorbital involvement in multiple myeloma is rare. Such involvement may result in exophthalmia, itself the first manifestation and presenting feature of myeloma. These lesions can respond remarkably to radiotherapy. The authors present a new case report.

Exophthalmos↗
PubMed1987

[Cancer of the cervix uteri in Tunisia. Clinical presentation and development over a 10-year period].

Carcinoma of the cervix is still common in Tunisia, where it occupies second place among malignant diseases in women. Accounting for 17% of the female population of the National Cancer Institute of Tunis, it is preceded only by breast cancer (27%). Study of the factors concurrent with the origin of carcinoma of the uterine cervix seems to indicate that its decrease is secondary to the lowered average age at marriage, to the fall in the reproduction rate among the population at large, and to improved socio-economic conditions among the poorer classes. Study of clinical features observed during two separate periods of 10 years shows a modification in the physiognomy of this cancer, with, notably, a larger frequence of lower stages (45% of stage II in 1984 vs 20% in 1974) and a slight tendancy towards the discovery of smaller non - or early - infiltrating tumors (4% in 1984 vs 0% in 1974). Efforts must continue to be made in the domaine of early detection, especially among the "high risk" population.

Age Factors↗
PubMed1985

[The paraneoplastic syndrome in nasopharynx cancer. 32 cases].

Thirty-two cases of paraneoplastic syndrome associated with nasopharyngeal carcinoma are reported. The prevalence of the syndrome in young subjects was striking: 29 of the patients were under 25 years of age. Seventeen presented with hypertrophic osteoarthropathy, 13 with clubbing of the fingers, 1 with dermatomyositis and 1 with myelemia due to excessive production of bone marrow cells. Twenty-eight patients had metastases which involved the lung in 24. These pulmonary metastases are held responsible for the osteoarticular paraneoplastic syndrome, but in our 4 patients without metastases the syndrome was probably caused by the primary tumour itself.

Adolescent↗