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Biomedical subjects

M M Weiss

Publications and source records attributed to M M Weiss.

At least 19 recordsLinked to original sources
PubMed1989

Corticosteroids in rheumatoid arthritis.

This report has presented evidence to support a disease-modifying role for corticosteroids in rheumatoid arthritis. It would appear that the efficacy of these agents in retarding the destructive course of rheumatoid disease has been substantially underestimated. Consideration for more liberal use of corticosteroids in the management of rheumatoid arthritis is warranted. Further study on new approaches to corticosteroid delivery is proposed.

Adrenal Cortex Hormones↗
PubMed1983

The use of monoclonal antibody to keratin in human epidermal disease: alterations in immunohistochemical staining pattern.

A monoclonal antikeratin antibody, designated AEl, was used to stain frozen sections of normal and abnormal human skin by the immunofluorescence and peroxidase-antiperoxidase techniques. In normal human epidermis and ichthyosis vulgaris, a nonproliferative epidermal disease, this antibody selectively stained epidermal basal cells. Very different staining patterns were observed in various other epidermal diseases. A suprabasal staining pattern was observed in psoriasis (16 cases), verruca (9), seborrheic keratosis (5), actinic keratosis (2), as well as the epidermis adjacent to certain epidermal neoplasms (4). Basal cell carcinoma (7) showed weak, homogeneous staining. In contrast, a disorganized pattern consisting of cells with various staining intensities was observed in Bowen's disease (2) and squamous cell carcinoma (4). Although the biochemical basis for these altered staining patterns remains to be elucidated, these results provide further evidence that epidermal keratin expression can be affected by various disease states. Moreover, our data suggest that a common alteration in keratin expression, as defined by the suprabasal AEl staining pattern, exists in psoriasis and a number of other benign hyperproliferative epidermal diseases.

Animals↗
PubMed1981

Fumigated mail.

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Europe↗
PubMed1979

Electromagnetic radiation emitted from video computer terminals.

There has been a developing concern about potential health hazards attributable to electromagnetic radiation from video computer terminals. Since users of these devices typically spend many hours daily in close proximity, they would be subject to chronic long-term exposures to any emitted radiation. Radiation was detected at frequencies ranging from 1.5 kHz to 1,420 MHz in the RF portion of the EM spectrum and from 350 nm to 600 nm in the ultraviolet and visible region. However, the levels were far less than the most restrictive permissible exposure levels established by any agency or government of any nation. There is no experimental or epidemiological evidence presently available to indicate that these levels of RF radiation have any deleterious effects on the human biological system.

Computers↗
PubMed1977

In vitro cultivation of the sporogonic stages of Plasmodium: a review.

Complete and continuous in vitro development of the sporogonic stages of the malarial parasite has not yet been accomplished, although success with erythrocytic stages (falciparum malaria) and exoerythrocytic stages (avian malaria) has been achieved. This lag in progress appears to be due to several inherent differences between sporogony and these other sequences of development. The Trager-Jensen system for in vitro development of erythrocytic stages of Plasmodium falciparum results in the formation of gametocytes, although these gametocytes have not yet been shown to be functionally mature. An improvement in culture conditions, leading to the formation of infective gametocytes, would be an important advance. Culture systems for the transformation of gametocytes to ookinetes have been described, but whether this can be easily accomplished for falciparum malaria remains to be determined. The subsequent stages of sporogony, leading from oocyst differentiation to the formation of mature, infective sporozoites, have been successfully grown in short-term in vitro cultures. The entire developmental sequence, however, has been obtained only by overlapping successive stages in different cultures. This has established that all phases of sporogony are inherently capable of being supported in vitro. Further improvements may come through a better understanding of appropriate culture conditions.

Animals↗
PubMed1976

Studies on Plasmodium ookinetes. 1. Isolation and concentration from mosquito midguts.

In a method for isolating a relatively clean suspension of concentrated Plasmodium berghei ookinetes from infected midguts of Anopheles stephensi at appropriate times after the infective blood meal, the ookinetes are freed from the midguts by enzymatic digestion, and then concentrated by means of a BSA/renografin gradient. The mean number of ookinetes recovered/midgut was 152. More than 95% of the recovered ookinetes were viable by the criteria of motility, incorporation of adenosine and leucine, and appearance on light and electron microscopic examination. Trypan blue exclusion was not a valid criterion for viability. These ookinetes were not useful for in vitro studies of further development due to the presence of contaminating microorganisms. Our attempts to determine their potential for further development in vivo have similarly not been successful. Nevertheless, our ability to obtain large numbers of ookinetes at defined times during development now permits further studies on their structure, biochemistry, and physiology, as well as comparison with ookinetes formed in vitro.

Animals↗
PubMed1976

Viruslike particles in malaria parasites.

The ultrastructural appearance of viruslike particles in several malaria parasites at different times in sporogony is described in detail. Emphasis is placed on particle size, 42 to 52 nm, density and the presence or absence of geometric configuration of particle aggregations in P. berghei ookinetes, and P. gallinaceum early oocysts. This particle appearance is compared with that noted in later oocysts of P. berghei, P. gallinaceum, and P. c. bastianelli and with negatively-stained particles obtained by fractionation of A. stephensi mosquito medguts heavily infected by P. berghei oocysts. Although particles are dispersed in later oocysts, particle size and shape is similar to that noted in the aggregates found in early forms. Aggregations of particles in a geometric configuration in ookinetes and early oocysts is associated with a particle of smaller diameter and the absence of a limiting membrane or envelope. This suggests an incomplete or nascent virus particle form. The observations of such particles in malaria and other blood parasites is compared with the present findings.

Animals↗