The functioning of the respiratory system and oxygen-transport function of the lungs were estimated in experiments on healthy people under the effect of exogenic hypercapnia. The external respiration is activated under conditions of hypercapnia of the given degree, an increase in the total and alveolar ventilation of the lungs testifies to this fact. Age differences are found in diffusive and specific diffusive capacity of the lungs for O2, which indicates to changes in the oxygen-transport function of the lungs. In teenagers the diffusive capacity of the lungs changes due to the gas-exchange surface area and in people of middle age - due to changes in the diffusive properties of the lungs air-blood barrier.

Adolescent↗

PubMedDate not supplied

[Effect of liposomes on tissue respiration in animals with acute hypoxic hypoxia].

Introduction of liposomas has been studied in experiments on Wistar rats for its effect on oxygen demand by tissues of the brain great hemispheres, lungs, liver and femoral muscle under acute hypoxic hypoxia due to inhalation by an animal of gas mixtures containing of 6.7-7.1% of O2. It is shown that after introduction of phospholipid liposomes as a lipin preparation against a background of acute and grave forms of hypoxic hypoxia the oxygen demand of tissues remains practically at the level of control values. This proves absence of the tissue oxygen debt that usually develops at hypoxic states. It is concluded that the organism tissues in the presence of liposomas do not practically suffer from the oxygen deficiency and introduction of lipin may be effective to prevent from development of the secondary tissue hypoxia.

Acute Disease↗

PubMedDate not supplied

[Activation mechanisms of lipid peroxidation in rat's tissue in various types of hypoxia].

The mechanisms of lipid peroxidation (LP) intensification in the rat myocardium, brain and liver were studied under hypoxic hypoxia and hemic hypoxia. The level of intensification depends on the type of hypoxia and is characterized by tissue specificity. It is shown that LP is activated by hypoxia. This activation is more pronounced under hemic hypoxia associated with more marked catecholamine accumulation, deficiency of the antioxidant glutathione system, decrease of the cytochrome c-oxidase activity. The level of lipid peroxides was higher in the rat liver under both types of hypoxia.

Animals↗

PubMedDate not supplied

[The effect of intermittent hypoxic training on pancreatic endocrine function in animals with diabetes mellitus].

The state of the pancreatic endocrine apparatus in diabetes, adaptation to hypoxia and both of them were studied in experiments with rats. Early stages of diabetes were accompanied by marked reconstruction of the pancreas. A decrease in the insulin level was followed by compensatory activation of glucagon- and somatostatine-producing systems which depended on the sex of animals. It was observed that adaptation to intermittent hypoxia exerted a positive effect on the diabetic process in rats, which was manifested by an increase in the insulin level in blood and beta-cells, inhibition of islet destruction, new formation of beta-cells in acinar tissue, and decrease of glucagon and somatostatine production.

Adaptation, Physiological↗

PubMedDate not supplied

[External respiration and gas exchange in healthy children under conditions of increased and decreased oxygen concentration in inspired air].

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Child↗

PubMedDate not supplied

[External respiration and gas metabolism in newborn infants with the respiratory insufficiency syndrome in hyperoxia].

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Asphyxia Neonatorum↗