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Biomedical subjects

M M Seredenko

Publications and source records attributed to M M Seredenko.

At least 19 recordsLinked to original sources
PubMed1999

[The effect of nitric oxide donors on the respiratory rhythm of an artificially superfused preparation of the brain of newborn rats].

The influence of an exogenous nitric oxide (NO) donor, sodium nitroprusside, and endogenous NO biosynthesis substrate, L-arginine, on integrated respiratory rhythm recorded from the phrenic nerve of the semi-isolated medullo-spinal preparations of the 3-to-4-days old rats was studied. Applications of 10.0 mcM of these drugs led to significant increase in the duration and amplitude of the inspiratory discharges (ID) in the phrenic nerve and to decrease of ID frequency. After the rostral ventrolateral (RVL) medulla (projectionally corresponds to "M" chemosensitive zone) had been separated by transection, such applications began to evoke a rise of ID frequency without significant changes of the duration and amplitude. Thus, we found the involvement of NO in the tonic inhibition of the respiratory rhythm by RVL medullary structures in the neonatal rats.

Animals↗
PubMed1999

[The adaptation of youth with different rates of morphofunctional development to physical loading].

There were studied morphofunctional peculiarities of biological development of 15-17-year-old boys' organisms on the bases of complex use, for this, of the level of physical development, rates of sex maturity and somatotype. On that base there were studied the individual peculiarities of their adaptation to the physical loads, which was directed to the development of endurance. It was ascertained, that the boys of the examined age groups, based on the complex differentiation are divided into 3 basic groups--fast, normal and slow rates of genesis. These typological groups differ by the measure and quantity of periods of long-term adaptation, and by the nature of adaptable changes in the organisms which are studied as a result of influence of long-lasted dosing loads, directed to the development of endurance.

Adaptation, Physiological↗
PubMed1998

[The effect of linoleyl hydroxamic acid on lipid peroxidation processes and on the enzymatic activity of the antioxidant system in rats under hypoxia].

It was studied the effect of new blocker of lipoxygenase way of arachidontic acid metabolism--linoleyl-hydroxamic acid--on the status of lipid peroxidation and antioxidant system in blood, heart, liver, lung and brain in rats under acute hypoxic hypoxia. It was shows that preliminary introduction of this substance lead to increase of antioxidant enzymes activity--superoxide dismutase and ceruloplasmine, and to decrease of lipid peroxidation level during hypoxia in blood, heart, liver and lung (without brain).

Acute Disease↗
PubMed1998

[The antioxidant action of taurine in acute hypoxic hypoxia].

It was found that preliminary treatment by amino acid taurine protected rats from lipid peroxidation intensification (expressed in terms of malondialdehyde and conjugated dienes contents) in the liver, brain and heart under acute severe normobaric hypoxic hypoxia. The mechanisms of the antioxidant action of taurine are connected to the prevention of lactate accumulation in tissues and cell membrane structure disorders (expressed in a decrease of membrane Na+, K(+)-ATPase activity). It was also shown that taurine reduced significantly a decrease of glutathione antioxidant system activity protecting tissues against reduced glutathione pool depletion and preventing a decrease of glutathione reductase and glutathione peroxidase activities in acute severe hypoxia.

Acute Disease↗
PubMed1997

[Nikolaĭ Nikalaevich Sirotinin and his school].

In a brief review of 50-year scientific activity of professor N. N. Sirotinin and his students the authors emphasize that this broad-minded scientist contributed to development of such disciplines as microbiology, pathophysiology, high-altitude, aerospace medicine. However, his main goal was evolution of reactivity and resistance, approaches to perfection of human health and performance. Much attention was paid to effects of low partial oxygen pressure on human and animal body, to hypoxic states of different origin. Methods of hypoxytherapy and hypoxic training are widely used in Russia and abroad. The contribution of academician N. N. Sirotinin to modern pathophysiology, high-altitude and aerospace physiology, internal and sport medicine is highly appreciated in Russia.

Aerospace Medicine↗
PubMed1996

[The physiological characteristics of the antioxidant properties of Lipin in bronchial asthma in children].

In children of 4-7 years old with bronchial asthma (BA) has been studied the values of lipid peroxidation, antioxidant status and some others in blood plasma and erythrocytes without and with the use of new drug Lipin. It was shown that in children with BA the malondialdehyde concentration increased, the superoxydedismutase activity decreased, the NAD concentration increased, and the ratio of superoxidedismutase/malondialdehyde greatly decreased in comparison with normal children. The use of Lipin led to diminuation of lipid peroxidation, to marked increase of superoxidedismutase activity, to decrease of NAD concentration, and to significant increase of superoxidedismutase/malondialdehyde ratio. These results were indicated on the expressed antioxidant properties of Lipin in children's with BA.

Administration, Inhalation↗
PubMed1994

[The physiological role of the structural-functional changes in the air-blood barrier of the lungs in supplying the body with oxygen under the action of extreme factors].

Hypoxic states, under the effect of extreme factors, induced changes in the endothelium of the lung capillaries irrespective of the nature of the factors (exo- or endogenous) causing the hypoxic state. Significant changes of the mitochondrial apparatus of the lung air-blood barrier cells occurred in the hypoxic hypoxia. The data obtained suggest that the thickness of the ABB, under extreme conditions, cannot serve as a parameter of the morphofunctional state of the lung ABB. The compensatory-adaptive response of the cell structures seem to decrease the oxygen diffusion from the alveolar gas into the blood of the lung capillaries.

Altitude↗
PubMed1992

[The morphofunctional characteristics of the pulmonary air-blood barrier in rats breathing gas mixtures with a high content of hydrogen sulfide].

The influence of gas mixtures with high concentration of pure hydrogen sulphide and natural gas of the Astrakhan deposit (NGAD) upon the morphofunctional state of the aerohematic barrier (AHB) and the surfactant system of the lungs was studied in 80 albino Wistar rats of 180-250 g body weight. The influence of both hydrogen sulphide and NGAD results in the appearance of morphofunctional alterations in the AHB and surfactant system of the lungs. However, if the action of hydrogen sulphide in concentrations of 300-330 and 600-700 mg/m3 is followed not only by pathological manifestations but also by mobilization of certain compensatory-adaptational mechanisms such as reinforcement of pinocytosis, the action of NGAD with the similar concentration of hydrogen sulphide seems to be too toxic, surpassing the possibilities of compensation, and there occurs the development of purely pathological phenomenon--pulmonary edema.

Animals↗
PubMed1990

Severe hypoxia activates lipid peroxidation in the rat brain.

The level of lipid peroxides, concentration of lactic acid in the blood and brain tissue homogenates were measured in rats under hypoxic hypoxia and hemorrhage. Significant correlation was found between the O2 supply-consumption ratio, the concentration of lactate and the level of lipid peroxides. It is suggested that the peroxidation process is activated by hypoxia.

Animals↗
PubMed1990

[The mechanisms of the disorder of external respiration in hypoxia].

Anesthetized rats breathed during 1 hr with gas mixtures containing 16 to 6 per cent of oxygen. At 6 per cent of oxygen, the hypoxia of pulmonary tissue and its processes of peroxide oxidation of lipids entails a sharp increase in elastic resistance against breathing. This is combined with insignificant disorders in tidal volume which is not compensated by an increase in the breathing rate. General mechanisms of external respiration disorders in various types of hypoxia and in stress, were revealed.

Animals↗
PubMed1990

[The physiological mechanisms of the antihypoxic action of the liposomes].

The effect of phospholipids introduced into the vascular bed in the form of liposomes, was studied in pats in conditions of breathing with hypoxic gas mixture containing 7% of oxygen in nitrogen. The liposomes were shown to improve the oxygen diffusion from the blood into tissues and from air to the blood. In the result of this, the degree of the tissue hypoxia is considerably reduced, the process of peroxide oxidation of lipids is inhibited, and the efficacy of external respiration and gas exchange is increased.

Animals↗
PubMed1990

[Biological effect of liposomes in hypoxic conditions of various etiologies].

The antihypoxic and antioxidative effects of phosphatidyl choline liposomes have been studied in hypoxic hypoxia, pneumonia, and acute blood loss. It was demonstrated that the body tolerance of persisting hypoxia increased on liposome administration due to elimination of lactate-acidosis, inhibition of lipid peroxidation and higher rate of oxygen diffusion through the biological barriers. The antihypoxic properties of the vesicles are determined by their remedial effect on the key mechanisms responsible for the development of hypoxic organ damage.

Animals↗
PubMed1989

[The electron microscopic characteristics of stress lung].

The influence of long-term (6 hours) immobilization stress on morphofunctional state of lung air-blood barrier was studied in experiments of the rats. It was shown that stress provoked the marked ultrastructural changes in the lungs, which were as follows: lung tissue oedema, pronounced thickening of lung air-blood barrier and its separate layers, edema-hemorrhagic syndrome, alveolar epithelial injury, disturbance of lung surfactant systems. Such a pathological complex may be designated as a "stress lung".

Animals↗
PubMed1989

[Use of helium-oxygen mixtures in respiratory hypoxia].

Substantiation is given to the approach to the differential prescription of helium-oxygen gas mixtures with a different oxygen concentration for relieving respiratory hypoxia which develops in the obstructive and restrictive types of ventilation abnormalities.

Adult↗