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Biomedical subjects

M M Rodrigues

Publications and source records attributed to M M Rodrigues.

At least 181 records · Page 10Linked to original sources
PubMed1976

Unusual eyelid involvement in tuberous sclerosis.

A two-week-old male infant had a nodular salmon-colored lesion on his right lower eyelid and hypopigmented mascular lesions on the abdomen and right thigh since birth. At five months of age he developed a generalized seizure disorder. Histologic examination of the eyelid lesion revealed an angiofibroma, which was an unusual initial site of involvement in tuberous sclerosis.

Collagen↗
PubMed1976

Malignant melanoma of the choroid with balloon cells a clinicopathologic study of three cases.

We report the findings on clinicopathologic examination of three patients with balloon cell melanoma of the choroid. Ophthalmoscopically, all three had small, slowly progressive tumors at the posterior pole, with an encircling yellow halo. With fluorescein angiography, the yellow halo showed fluorescence similar to the remainder of the tumor, thus differentiating this substance from lipofuscin pigment, drusen and exudates. Light microscopy demonstrated prominent balloon cells which were most numerous at the tumor margins. These cells showed variable melanin pigmentation and were negative for lipid, acid mucopolysaccharide, and glycogen. Special enzyme studies (lactic dehydrogenase, succinic dehydrogenase, acid phosphatase, beta glucoronidase and aminopeptidase) demonstrated some similarity to melanocytic cells. Electron microscopy revealed premelanosomes and complex melanosomes in the cytoplasm of balloon cells without evidence of significant lipid.

Acid Phosphatase↗
PubMed1976

Orbital amyloidosis.

A 51-year-old male presented with a chronic asymmetrical ptosis which was variable. Repeated anticholinesterase testing gave equivocal responses. The patient was treated for myasthenia gravis until a mass was detected in the orbit. Although rare, localized orbital amyloidosis should be considered in the diagnosis of patients with ptosis, particularly when the results of anticholinesterase testing are equivocal.

Amyloidosis↗
PubMed1975

Corneal elastosis. Appearance of band-like keratopathy and spheroidal degeneration.

Clinical and pathologic studies of six corneas from patients with band-like keratopathy and spheroid degeneration were performed. These included cases of noncalcific band keratopathy; in one case very early changes in Bowman membrane were demonstrated by light and electron microscopy. Two other corneas displayed more advanced degeneration that manifested clinically as irregular golden yellow plaques. One case of corneal spheroid degeneration was associated with lattice dystrophy of the cornea. The corneal deposits may be best characterized as a form of elastotic degeneration and were associated with intense autofluorescence.

Adolescent↗
PubMed1975

Exogenous corneal ulcer caused by Tritirachium roseum.

A 29-year-old white man developed a corneal ulcer following trauma to his left cornea by a piece of wire. Tritirachium roseum, a saprophytic fungus, was cultured from corneal scrapings and demonstrated in the corneal button by histopathologic examination.

Adult↗
PubMed1975

Endothelial alterations in congenital corneal dystrophies.

We studied the clinical and ultrastructural findings in three different types of congenital endothelial dystrophies: hereditary posterior polymorphous dystrophy, congenital hereditary corneal dystrophy, and a nonhereditary congenital endothelial dystrophy. In the first patient, with hereditary posterior polymorphous dystrophy, a layer of epithelial-like cells was observed adjacent to endothelial cells on the posterior corneal surface. Descemet's membrane displayed a multilaminar pattern and consisted of an anterior, thin (3 mu), PAS-positive layer and a posterior, thicker (25 to 30 mu) zone of abnormal collagen. The second patient, with congenital hereditary endothelial dystrophy, showed a thickened multilaminar Descemet's membrane and scant endothelial cells. In the third patient with nonhereditary congenital endothelial dystrophy, the thickened Descemet's membrane was lined posteriorly by a retrocorneal fibrous membrane. A few degenerated endothelial cells were present. All three cases showed 100- to 110-nm banding posteriorly. In these three clinically distinct entities, electron microscopy was useful in demonstrating the unusual form of endothelial transformation to epithelial-like cells in one patient, in contrast to the more common fibroblast-like metaplasia of endothelial cells seen in the other two patients.

Adolescent↗
PubMed1975

Corneal clouding with increased acid mucopolysaccharide accumulation in Bowman's membrane.

Two infants had bilateral congenital corneal clouding and abnormal acid mucopolysaccharide accumulation in a thickened Bowman's membrane. This unusual entity was not associated with acid mucopolysaccharide deposits in the skin and visceral tissues or with increased levels of acid mucopolysaccharide in the urine. The similarity and differences have been compared to the systemic mucopolysaccharidosis and macular corneal dystrophy.

Basement Membrane↗
PubMed1975

Retinal pigment epithelium in incontinentia pigmenti.

An 18-month-old white girl with incontinentia pigmenti presented clinically with leukokoria of the right eye. B-scan ultrasound demonstrated a retrolental mass consistent with a detached retina. Histologic examination of the skin revealed changes compatible with the intermediate verrucous phase of the disease. Microscopic examination of the right eye showed retinal detachment and nodular proliferation of the retinal pigment epithelium. The nodules contained macrophages laden with melanin and lipofuscin. An unusually large amount of lipofuscin was present for a child of this age. The basic pigmentary abnormality may affect the retinal pigment epithelium, resulting in changes in the overlying neurosensory retina that may lead to the retinal dysplasia or retinal detachemnt often associated with this condition.

Cataract↗
PubMed1975

Exogenous fungal endophthalmitis caused by Paecilomyces.

A 17-year-old white boy developed a fulminating corneal infection and endophthalmitis in his left eye after trauma. He was treated with antibiotics and corticosteroids for one week prior to diagnosis. A saprophytic fungus, Paecilomyces viridis, was cultured from corneal scrapings and was demonstrated in the vitreous cavity by histopathologic examination.

Adolescent↗
PubMed1975

Recurrent corneal granular dystrophy: a clinicopathologic study.

Recurrence of granular corneal dystrophy occurred in two patients following two successive penetrating corneal grafts. In the first patient, the deposits involved the central stroma of the donor cornea, almost to the level of Descemet's membrane. The second patient had predominantly subepithelial deposits in bilateral recurrences. Electron microscopy revealed rod-shaped, electron dense material typical of granular dystrophy in both patients.

Adult↗