Search PubMed⌕ Search

Biomedical subjects

M M Rao

Publications and source records attributed to M M Rao.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Plant anticancer agents. IX. Constituents of Hyptis tomentosa.

The twigs, leaves, and flowers of Hyptis tomentosa were found to owe their major cytotoxic activity to the presence of desoxypodophyllotoxin (4), but the two weakly cytotoxic flavones 5-hydroxy-4',6,7,8-tetramethoxy flavone (3) and 5-hydroxy-4',3,6,7,8-pentamethoxy flavone (2) also contributed to the total cytotoxicity of the crude extracts. The flavones eupatorin (6) and 5-hydroxy-3',4',6,7-tetramethoxy flavone (5) were isolated as inactive constituents, together with the lignan sesamin (1).

Animals↗
PubMedDate not supplied

Expanded polytetra fluoroethylene (PTFE) graft in hemodialysis.

Currently, PTFE grafts are regarded to be the alternative method of choice for patients with failed conventional fistulae. Observation over a longer period is necessary to assess the long term patency rate. Our experience in the use of PTFE grafts in providing vascular access for selected patients is reviewed. Thirty grafts were implanted in twenty-six patients over a sixteen-month period. Complications noted were thrombosis (six patients) and infection (two). Twenty patients were successfully hemodialysed without complications. Two additional patients had access provided for long term parenteral therapy or transfusion.

Blood Vessel Prosthesis↗
PubMedDate not supplied

Evaluation of ketorolac, ibuprofen-paracetamol, and dextropropoxyphene-paracetamol in postoperative pain.

STUDY OBJECTIVE: To compare the analgesic efficacy of ketorolac, ibuprofen-paracetamol (acetaminophen), and dextropropoxyphene-paracetamol in postoperative pain. DESIGN: Randomized, double-blind, parallel, single-dose study. SETTING: Multicenter, with five centers participating. PATIENTS: One hundred sixty patients with moderate to severe postoperative pain requiring oral analgesics were enrolled. Seventeen patients were excluded from final analysis due to deviation from protocol. INTERVENTIONS: Ketorolac tromethamine 10 mg, a combination of ibuprofen 400 mg plus paracetamol 325 mg, or a combination of dextropropoxyphene 65 mg plus paracetamol 400 mg was given orally to patients with moderate to severe baseline pain. MEASUREMENTS AND MAIN RESULTS: Pain intensity and pain relief scores were rated at baseline, at 30 minutes, and hourly to 6 hours. Until the end of first hour, analgesia was similar for all three regimens. Ketorolac had a significantly higher analgesic effect than the two combinations between hours 2 and 6. Analgesia was similar for the two combinations. For all three test drugs the frequency of adverse effects was similar. CONCLUSIONS: Ketorolac 10 mg is a superior analgesic to ibuprofen-paracetamol or dextropropoxyphene-paracetamol in the treatment of postoperative pain.

Acetaminophen↗