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Biomedical subjects

M M Peel

Publications and source records attributed to M M Peel.

35 records · Page 2Linked to original sources
PubMed1984

Endocarditis caused by Rothia dentocariosa.

A case of infective endocarditis caused by Rothia dentocariosa is described in a 53 year old man with a history of rheumatic fever. R dentocariosa is a component of the oral microbiota and has only rarely and recently been recognised as a human pathogen. In this patient the oral flora was the probable source of infection, with a broken molar tooth providing the probable avenue for infection.

Actinomycetaceae↗
PubMed1982

Isolation of Legionella pneumophila from hospital water systems in Victoria.

A survey of water symptoms in 12 Victorian hospitals was undertaken to establish the prevalence of Legionella pneumophila in buildings not known to be associated with cases of Legionnaires' disease. Samples of hot, cold and shower water were taken, together with water from cooling towers, and isolation was attempted by guinea-pig inoculation. Legionella pneumophila was not isolated from any of the hot, cold or shower samples, but six strains were isolated from five of the cooling towers sampled.

Adult↗
PubMed1982

Osteomyelitis and septic arthritis caused by Kingella kingae.

The clinical and bacteriological findings in two cases of osteomyelitis and one case of septic arthritis caused by Kingella kingae are presented. This appears to be the first report providing clear evidence for a pathogenic role for this species in bone and joint infections.

Adolescent↗
PubMed1981

Actinobacillus actinomycetemcomitans infection in the oral cavity.

An abscess that developed following the extraction of periodontally involved teeth persisted after surgical drainage and ampicillin therapy. Subsequent culture of pus from this abscess gave a pure growth of Actinobacillus actinomycetemcomitans which was resistant to ampicillin. Surgical drainage and the use of appropriate antibiotic therapy cleared the infection. The identification of A. actinomycetemcomitans and the types of infection it causes are described. The probable mechanism of infection by the bacterium is discussed. A case that illustrates the importance of the microbiologic examination of pus from dental abscesses is reported.

Abscess↗
PubMed1980

Isolation of group EF-4 bacteria in Australia.

A bacterial strain isolated from dog-bite wound was identified as belonging to a group which is so far unnamed but which has been tentatively designated Group EF-4 by workers at the Center for Disease Control, Atlanta, USA. Although this appears to be the first reported isolation in Australia of a strain belonging to this group, it is possible that strains of Group EF-4 are not infrequently recovered from dog-bite wounds but, when they are, they may either not be identified or be dismissed as skin contaminants. Characteristics are presented for differentiating Group EF-4 from Pasteurella multocida, the bacterium typically associated with animal bite wounds in humans.

Animals↗
PubMed1979

Colonization of an amputation site by Flavobacterium odoratum after gentamicin therapy.

Flavobacterium odoratum was isolated from the stumps of the amputated toes of a debilitated patient. Gentamicin therapy and the poor state of health of the patient provided suitable conditions for this gentamicin-resistant species to multiply. When the gentamicin therapy was stopped, and as the patient's heal improved, F. odoratum gradually disappeared to be replaced by Staphylococcus aureus. This appears to be the first report of the isolation of F. odoratum in Australia, and it indicates the potential of this resistant species to act as a source of infection for groups at risk.

Amputation Stumps↗
PubMed1979

Pseudomonas paucimobilis from a leg ulcer on a Japanese seaman.

Pseudomonas paucimobilis was isolated in pure culture from an ulcer on the leg of a Japanese seaman while in an Australian port. A description of the isolate is given. This may be the first report of a human infection in which this recently characterized species is implicated as a pathogen.

Australia↗
PubMed1978

Relationship between lymphocyte response to tetanus toxoid and age of lymphocyte donor.

An investigation of the in vitro responsiveness of peripheral blood lymphocytes to tetanus toxoid was undertaken to determine the extent to which such reactivity might reflect in vivo reactions to tetanus toxoid immunization. It was found that lymphocyte transformation in the presence of tetanus toxoid, as measured by the uptake of tritiated thymidine, did not differ significantly for the group giving local or systemic reactions to tetanus toxoid and an immune control group. However, a striking inverse relation between lymphocyte reactivity to tetanus toxoid and age of the cell donors of both groups became clear. Such an age-related decline in the in vitro responsiveness of peripheral blood lymphocytes to a specific antigen has apparently had not been reported previously in man.

Adult↗
PubMedDate not supplied

Effect of cell-cell interactions on the observable strength of adhesion of sheets of cells.

Previous research in cellular adhesion has focused primarily on studying isolated cells under conditions where cells do not interact with each other. However, in vivo cells form sheets where both cell-substratum and cell-cell interactions contribute to the overall adhesive behavior. Our understanding of how cell-cell and cell-substratum interactions affect the overall process of cell adhesion in these situations is limited. To address this problem, we developed a systematic approach to evaluate how cell-cell and cell-substratum interactions affect the critical shear stress for detachment for semi-confluent and confluent sheets of cells. Our studies were based on subjecting cultures of adherent cells to a defined hydrodynamic flow in a radial-flow chamber with a gap height of 140 microm. Using phase-contrast microscope imaging and analysis we measured shear-dependent patterns of detachment as a function of the extent of cell confluency. Our results show that the critical shear stress for detachment is maximum at intermediate extents of confluency of 10%-40%. These results have important implications for sodding vascular grafts and tissue engineering.

Animals↗