Biomedical subjects

M M Orren

Publications and source records attributed to M M Orren.

4 recordsLinked to original sources

PubMed1979

Auditory evoked potentials and auditory behavior following prenatal and perinatal asphyxia in rhesus monkeys.

Two types of asphyxia were studied in monkeys, total asphyxia during mid-pregnancy (94--98 days gestation) and combined partial and total axphyxia at term (165 days gestation). Auditory evoked potentials and the acquisition of 2 auditory discrimination tasks were studied in asphyxiated animals as well as in group of controls. The brains of all asphyxiates were examined histologically. No auditory discrimination deficit was found in the asphyxiated animals; however, the auditory evoked potentials differentiated between control and asphyxiated animals, especially those with verified inferior colliculus damage.

Animals↗

PubMed1978

Evoked potential studies in petit mal epilepsy. Visual information processing in relation to spike and wave discharges.

The evoked potential has been useful in studying characteristics of the epileptic nervous system. To investigate whether an alteration in sensory processing is possibly related to behavioral unresponsiveness observed to precede spike and wave bursts, average visual evoked potentials (VEPs) were studied during a 4.0 sec preburst interval in 6 patients with petit mal epilepsy. Individual responses, evoked by photic flashes, were averaged as a function of flash-to-burst interval. In 3 subjects with classical bursts of spike and wave, the average VEP was degraded 0.5 sec or less before burst onset. In 3 subjects with atypical electroencephalographic seizure discharge, VEP degradation was not seen. Some possible interpretations concerning the significance of the VEP alterations were discussed.

Adolescent↗

PubMed1977

Attention.

Explore the source record for details and available documents.

Animals↗

PubMed1975

Relation between ocular manifestations and onset of spike-and-wave discharges in petit mal epilepsy.

Ocular manifestations are prominent in petit mal attacks. The nuclei innervating the extraocular muscles lie in mesencephalic and pontine regions of the brainstem which have been regarded by some as critical areas in the generation of petit mal attacks. Ocular signs and their timing relative to spike-and-wave onset were studied cinematographically in 4 patients with petit mal epilepsy. Each patient showed a consistent pattern of eye deviation or fixation during spike-wave bursts. Neither the activation of oculomotor pathways, as indicated by eye deviation, nor their inactivation, as suggested by interruption of ongoing elicited ocular activity, preceded the appearance of spikewaves. Because ocular manifestations began only after the onset of spike-wave, this study provided no evidence that brainstem oculomotor regions were involved in the initiation of these petit mal attacks.

Adolescent↗