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Biomedical subjects

M M Molokhia

Publications and source records attributed to M M Molokhia.

At least 19 recordsLinked to original sources
PubMed1994

The inhibitory effects of topical chelating agents and antioxidants on nickel-induced hypersensitivity reactions.

BACKGROUND: Nickel sensitivity is a common problem, often causing significant morbidity from chronic eczematous dermatitis. The main treatment, topical steroids, usually is unable to suppress the dermatitis completely. OBJECTIVE: Our purpose was to study the effects of "barrier" ointments containing either chelating agents (clioquinol or ethylenediaminetetraacetic acid [EDTA]) or antioxidants (ascorbic acid or alpha-tocopherol) and 1% hydrocortisone on nickel-induced hypersensitivity reactions. METHODS: Nickel-sensitive subjects were challenged with nickel-containing coins coated with the desired barrier ointment and their inhibitory effects observed. Patients with bilateral hand or earring dermatitis explored the efficacy of these agents in clinical use. RESULTS: Clioquinol (3%) completely abolished the allergic reaction in all 29 subjects tested. EDTA (15%), ascorbic acid (20%), and alpha-tocopherol (10%) were less effective, and 1% hydrocortisone had no significant effect. In clinical use sites treated with a commercially available preparation containing 3% clioquinol and 1% hydrocortisone showed marked clinical improvement in all 10 subjects. CONCLUSION: Clioquinol is a potent inhibitor of nickel-induced hypersensitivity reactions and is feasible to use as a barrier ointment to block the allergenic effects of nickel in sensitive patients.

Administration, Topical↗
PubMed1987

The dissolution of metallic nickel in artificial sweat.

The dissolution of neutron-irradiated metallic nickel in an artificial sweat formulation has been studied. Variations in dissolution rate were found over a pH range of 3.5 to 6.5, a temperature range of 10 to 40 degrees C and for times up to 6 h. The presence of oxygen increases the dissolution rate markedly. Typical dissolution rates at 30 degrees C vary from 2 X 10(-7) g Ni X cm-2 X min-1 at a pH of 3.5, to 1 X 10(-9) g Ni X cm-2 X min-1 at a pH of 6. The relevance of the data to clinical aspects of nickel dermatitis is discussed.

Dermatitis, Contact↗
PubMed1980

Zinc absorption in Crohn's disease.

Zinc deficiency is a potential complication of Crohn's disease and we have searched for evidence of this and assessed the possibility that malabsorption of zinc might be a cause. Serum zinc concentrations in 33 patients suffering from Crohn's disease were significantly lower than in 58 normal control subjects (9 . 18 +/- 2 . 3 mumol compared with 13 . 6 +/- 1 . 73 mumol, P < 0 . 0005). Serum zinc correlated well with serum albumin concentrations and the low serum zinc may simply reflect the low serum albumin. Thus its value as an indicator of zinc deficiency is poor. We studied zinc absorption in seven patients with Crohn's disease and compared it with the results obtained previously in five normal subjects using a new technique involving a short-lived isotope of zinc (69mZn). Plasma appearance curves, constructed after an oral dose of isotope, and disappearance curves, after an intravenous dose, were used in a deconvolution computer programme to calculate zinc absorption. Compared with normal subjects, zinc absorption was considerably impaired in patients with Crohn's disease (range 9--45%, compared with 38--75%). This abnormality is a potential cause of zinc deficiency in patients with Crohn's disease.

Adolescent↗
PubMed1977

Culture and microscopy of microorganisms in frozen sections.

A simple method is described in which frozen sections are prepared from tissue cell suspensions with added microorganisms and then cultured. The enhanced growth of the organisms makes their indentification easier. A number of applications is suggested.

Culture Media↗
PubMed1970

Zinc and the skin.

Explore the source record for details and available documents.

Activation Analysis↗
PubMed1969

Tissue distribution of trivalent antimony in mice infected with Schistosoma mansoni.

The work described in this paper is designed to use the very high analytical sensitivity of neutron-activation analysis. The antimony content of individual organs and pieces of organs have been analysed as part of an investigation of the chemotherapy of schistosomiasis. The results illustrate the great, and as yet relatively unapplied, value of this technique in dealing with the investigation of trace elements in biological systems. Values such as those given form firm bases on which further studies can be built and show that the single animal has the same metabolic reactions as those deduced from bulked samples, but of course with individual variations.

Animals↗