Biomedical subjects

M M Linder

Publications and source records attributed to M M Linder.

At least 37 records · Page 2Linked to original sources

PubMed1978

[Acute ischemic gastric mucosal and duodenal lesions in dogs: "stress ulcer" after experimental disseminated intravascular coagulation].

Experimental disseminated intravascular coagulation (DIC) without considerable effect on blood pressure is shown to produce within 80 min acute mucosal bleeding in stomach and duodenum. A documented high degree of tissue hypoxia caused by mucosal microthrombosis is necessary for the genesis of mucosal lesions. These results stress the necessity to look for DIC in patients with upper gastrointestinal "stress ulcers".

Animals↗

PubMed1978

[Stomach movement following selective gastric vagotomy: correlation of roentgen contrast studies and electromyography in the conscious dog].

Electrical gastric activity in the alert dog was continuously registered by bipolar steel electrodes simultaneously with contrast x-ray studies. Delayed gastric emptying in the postoperative period following selective gastric vagotomy and pyloroplasty can be attributed to specific changes of electrical activity: 1. Electrical potential units become irregular in amplitude and frequency; 2. electrical activity of antrum is no longer synchronized with the corpus; 3. appearance of high frequency, atypical electrical activity in the antrum is associated with gastric motor inactivity; 4. peristalsis and emptying are linked to the de novo appearance of action-potential bursts.

Action Potentials↗

PubMed1977

[Preventive gastrectomies before kidney transplantations].

Gastroduodenal bleeding or perforation occurs in 3.5 to 60% of renal transplant patients. Mortality ranges from 35 to 75%. Experience with prophylactic gastric surgery is based on 61 patients with chronic hemodialysis, who were prepared for renal transplantation since 1974. History, presence of ulcer disease or hyperchlorhydria were assumed to represent a gastroduodenal risk. All 20 patients with such a risk-factor received prophylactic gastric surgery (high risk: selective gastric vagotomy + hemigastrectomy in 12, low risk: selective proximal vagotomy in 6; truncal vagotomy + drainage in 2 cases). Postoperatively there were no serious complications, no lethality.

Gastrectomy↗

PubMed1977

[Electromyographic studies of the stomach following selective proximal vagotomy in the awake dog].

Electrical and mechanical activity of the stomach following selective proximal vagotomy (SPV) were studied with 79 single experiments in 10 awake dogs. The influence of several pharmacological agents and feeding was tested: 1. The AP-Index of the gastric electrical activity rises to 1. 2. High frequency, atypical electrical activity resulting in mechanical inactivity increases with the postop. time interval. It reaches 60% of measured time on the 7th postop. day. 3. Normal electrical coupling of corpus and antrum is lost. 4. Pentagastrin increases the frequency of AP-rhythm only in the denervated corpus. 5. Carbachol and insulin have no such effect. 6. Feeding decreases electrical frequency in the innervated antrum. The altered electrical activity explains the known impairment of gastric emptying following SPV. The electrical desynchronization of corpus and antrum and the increased incidence of high frequency potentials in the antrum seems to overcome the high AP-Index.

Action Potentials↗

PubMed1976

[Intraoperating measuring of tissue oxygen pressure on the surface of the gastric mucosa. A new method for the control of complete vagotomy of the stomach].

A new method for the control of complete gastric vagotomy. Anew method is presented to control the completeness of gastric vagotomy. The procedure is based on measuring of gastric mucosa tissue oxygen pressure as an equivalent for the diminished perfusion of gastric mucosa after vagotomy. The results up to now proved the method reliable. Since we practice this method in quite a number of vagotomies primarily not severed vagal branches could be found and cut later.

Animals↗

PubMed1976

Measurements of oxygen tension from the canine gastric mucosa under the influence of vasoactive and acid stimulating agents and following vagotomy. Implications on the pathophysiology of peptic ulceration.

By the use of a multiwire platinum electrode mucosal tissue pO2 from the canine gastric antrum is continuously recorded. Injection of norepinephrine causes a short, steep fall of mucosal pO2, naftidrofuryl elevates mucosal pO2 for several minutes in spite of reduced arterial blood pressure, pentagastrin produces a biphasic response, a temporary rise of mucosal pO2 is followed by a longer lasting decrease, vagotomy causes a considerable and more persistent drop of mucosal pO2. These experimental findings are discussed in their possible relations to the clinical problem of ulcer formation and therapy of gastroduodenal bleeding.

Animals↗

PubMed1975

[The effectiveness ot thyroid-hormone therapy following goiter-resection].

The effectiveness of a postoperative thyroid-hormone therapy in preventing a goiter-recidiv was investigated two years after goiter-resection. Of 3381 patients with goiter, who were operated on in the years 1964 to 1973 in the Surgical Department of the Krankenhaus Nordwest in Frankfurt/Main, Germany, 129 patients who were operated on in the first six months of 1969, were questioned and examined in a follow-up study. A rezidiv-goiter was found in 4, 6 p.c. of patients. If only palpable recidiv-goiters are taken into consideration 2, 3 p.c.), patients without postoperative thyroid-hormone therapy developed a recidiv goiter twice as often as patients with thyroid-hormone therapy.

Adolescent↗

PubMed1975

[O2 pressure on liver surface following portacaval anastomosis and administration of vasoactive substances in dogs with normal livers].

1) Following acute portocaval anastomosis in healthy dog liver tissue - pO2 drops by 23%, an extent regulary occuring in hour long laparotomy. 2) Intravenous octapressin lowers splanchnic blood flow, concomitantly liver blood-flow and tissue -pO2 is decreased. 3) In contrast to octapressin orciprenalin improves liver blood-flow and tissue-pO2. 4) By shunting of arterial blood through the gut norepinephrine causes a rapid and lasting elevation of liver tissue-pO2.

Animals↗

PubMed1975

[Electric and mechanic gastric activity under insulin, penta-gastrin, carbachol and food ingestion in the wakeful dog].

The effect of insulin, pentagastrin, carbachol and feeding on the electrical and mechanical activity of the stomach was examined in the conscious dog. In these experiments vagal stimulation, a gastric hormone, a parasympathetic agent and distention elecited a similar stimulation of electrical and mechanical activity. The activation occurred in case of insulin only after sufficient lowering of the blood glucose level, in case of the other tested stimulants after a few minutes.

Animals↗

PubMed1974