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Biomedical subjects

M M Il'kovich

Publications and source records attributed to M M Il'kovich.

At least 19 recordsLinked to original sources
PubMed2006

[Endobronchial biopsy in the diagnosis of pulmonary sarcoidosis].

Bronchofiberscopy (BFS) with endobronchial biopsy (EBB) was performed in 66 patients with pulmonary sarcoidosis (PS). Transbronchial biopsy (TBB) was made in 49 patients from this group to compare the diagnostic value of EBB and TBB. The normal endoscopic picture was observed in 19.6% of patients. Bronchial mucosal hypervascularization and thickening were found in 25.7% of cases; the signs of enlarged bronchopulmonary lymph nodes were detected in 13.6%; catarrhal endobronchitis in 10.6%, and tuberosity changes in 4.5%. Epithelioid granulomas in the bronchial mucosa were identified in 37.8% of cases (30.75 and 39.6% in the intact and abnormal mucosa, respectively). The diagnostic value of TBB was 65.3%. EBB could reveal epithelioid-cell granulomas in 4 of the 17 patients with negative TBB. The findings suggest that BFS with EBB should be included as a necessary diagnostic method for the examination of patients with PS.

Adult↗
PubMed2006

[Early diagnosis of pulmonary hemodynamic disorders in patients with pulmonary sarcoidosis].

A hundred and eleven patients with pulmonary sarcoidosis (PS) were examined to detect early impairments of pulmonary hemodynamics and myocardial function. A package of examinations included Doppler echocardiography at rest and with the Valsalva test, as well as electrocardiography and myocardial scintigraphy. In patients with early PS, right ventricular diastolic dysfunction is shown to be preceded by systolic dysfunction, as manifested itself in the altered ratio of different phases of right ventricular filling. As a method for early diagnosis of latent hypertension, the authors propose to use the Valsalva test to create a short-term volume overload of the right cardiac cavities. The study has indicated that left cardiac dilatation, decreased ejection fraction, left ventricular diastolic dysfunction, and the presence of large focal portions of fibrosis in the ventricular myocardium, interventricular septum, and papillary muscles can be considered to be early Doppler echocardiographic signs of sarcoidosis of the heart in patients with PS.

Acute Disease↗
PubMed2005

[Monitoring and treatment of severe bronchial ashma in adults: results of national multicenter trial NABAT].

AIM: To study quality of monitoring, features of a course and therapy of severe bronchial asthma (BA) in Russia. MATERIALS AND METHODS: The trial recruited 378 patients with severe bronchial asthma (SBA) in 7 cities of Russia. Each center participating in the study filled in individual case sheets recording demographic, clinical, monitoring, pharmacotherapeutic data. A special focus was on factors influencing the disease course. The chi-square and Mann-Witney criteria were used. RESULTS: It was found that current recommendations of BA patients' management are not used in full. Most of the patients do not receive adequate therapy. Phenotypes of uncontrolled course of severe BA are prevalent. The key role of adequate management of severe BA patients in control of the disease is shown. CONCLUSION: Wider use of updated recommendations on therapy and monitoring of BA with special focus on patients with uncontrolled course of the disease is urgent. Fulfilment of all the components of management of a patient with bronchial asthma recommended by GINA including the patient education and control over the disease triggers contribute much to effective treatment and control over BA.

Adult↗
PubMed1996

[Weight-reducing diet therapy in the combined treatment of pulmonary sarcoidosis].

We have studied the effect of therapeutic fasting in 76 patients with pulmonary sarcoidosis (28, 45 and 3 patients with stage I, II and III, respectively). Fifty-two patients with PS stage I, II and minimal clinical symptoms received fasting alone. Twenty-four patients with PS stage II, III and frequent recurrences received combined treatment (fasting and oral corticosteroids). The efficacy of the treatment was evaluated by clinical symptoms, X-ray picture, pulmonary capillary blood flow and immunological parameters. We have found that therapeutic fasting reduced clinical symptoms in 85% of the patients, improved x-ray picture in 62% of the patients. Positive trend was also registered in immunological parameters. Therapeutic fasting produced maximal positive effect in patients with PS stage I, II and duration of the disease less than 1 year. Patients with PS stage II, III and the disease duration more than 1 year should be treated with fasting in combination with corticosteroids.

Adult↗
PubMed1989

[Steroid hormone and trace element content of the blood in patients with disseminated processes of the lungs].

Blood testosterone, estradiol, hydrocortisone, iron, zinc, and copper levels in males and female patients with lung sarcoidosis, idiopathic fibrosing alveolitis and histiocytosis X were studied. The female patients were in the menopause. A significant decrease in the levels of testosterone and zinc and an increase in the levels of estradiol and copper were revealed in the patients with alveolitis and histiocytosis X. In the patients with lung sarcoidosis a significant decrease in the content of zinc and an increase in the contents of estradiol and copper were stated. There was a relationship between the magnitude of the changes in hormone and trace element levels and the respiratory failure severity.

Adult↗
PubMed1986

[Disseminated processes in the lungs--a current problem of modern pulmonology].

A total of 453 patients with pulmonary disseminations were investigated. A clinico-statistical study of 16,000 adults estimated at 93.7 per 100,000 the prevalence of disseminated pulmonary conditions among the adult population. The referral and clinical diagnoses coincided in 17.4% of cases only, while the time between the emergence of the first symptoms and the final diagnosis averaged 21 +/- 3.3 months. The most valuable diagnostic signs were identified using the association criterion. They were: dyspnea, labored inspiration, hemoptysis, crepitation, spontaneous pneumothorax, roentgenologic evidence of raised diaphragmatic vaults and enlarged mediastinum lymph nodes, as well as certain neutrophil and lymphocyte levels in lavage fluid (Chuprov's coefficient between 0.32 and 0.42). Major management principles are developed with reference to stages of fibrosing alveolitis and granulomatosis.

Adult↗
PubMed1984

[Clinico-functional characteristics of idiopathic fibrosing alveolitis (Hamman-Rich syndrome)].

The clinical and functional features of idiopathic fibrosing alveolitis (IFA) were analyzed in 31 patients. In 24 patients, the diagnosis was confirmed by histological study of the pulmonary tissue obtained by means of open lung biopsy or at autopsy. Progressive dyspnea was the earliest clinical symptom of IFA. High temperature, weight loss, cyanosis and other symptoms were characteristic of an acute disease course. Crepitation was the most characteristic symptom as far as the objective data are concerned. Detailed examination of respiratory function with the use of spirography, general plethysmography, forced oscillation technique, study of the diffuse capacity of the lungs and blood gases, and other methods showed that the most characteristic functional features of pulmonary respiration in IFA involved a decrease in the static pulmonary volumes, an increase in elastic pulmonary resistance, normal patency of the large and medium bronchi, and a diminution of the diffuse capacity of the lungs during respiratory arrest, as well as that of the diffuse capacity of the alveolocapillary membrane. The data obtained indicate that today one can discuss only the most characteristic rather than the pathognomonic clinical and functional symptoms of IFA.

Adolescent↗