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Biomedical subjects

M M Hetherington

Publications and source records attributed to M M Hetherington.

3 recordsLinked to original sources

Eating behavior in eating disorders: response to preloads.

Eating behavior in eating-disordered subjects was investigated by recording food intake and subjective ratings following three preloads differing in calories, weight and connotation. Subjects were patients with a DSM-IIIR diagnosis of anorexia nervosa or bulimia nervosa and nonpatient volunteers (normal-weight or overweight dieters, and normal-weight nondieters). After all preloads, anorectics ate significantly less than all other subjects except normal-weight dieters, and anorectics rated hunger and desire to eat consistently lower and fullness greater than all other subjects. When analysis of intake was adjusted for body weight, anorectics and normal-weight dieters still consumed significantly less than controls. Anorectics selected foods that were lower in fat and carbohydrate and ate a larger proportion of calories as protein than the other subjects. All groups decreased subsequent intake after the high-calorie preload except bulimics. This study demonstrates that the regulatory capacity of eating-disordered individuals can be investigated and that aberrant eating behavior was observed.

Adult

Failure of naltrexone to affect the pleasantness or intake of food.

Two separate studies were conducted to investigate the effects of oral naltrexone on the pleasantness ratings of foods and food intake. In both studies, normal-weight, nondieting males rated hunger, fullness, mood and the pleasantness of the taste of a variety of foods before and after double-blind administration of 50 mg of naltrexone or placebo. All subjects received a test meal, in a counterbalanced, repeated measures design. In the first study, 12 subjects were given a self-selection test meal after overnight deprivation. In the second study 14 subjects were given an ice cream test meal with no deprivation. In both experiments the pleasantness of the taste of the foods, sensory-specific satiety, hunger ratings and overall energy intake were not differentially influenced by naltrexone administration. In Experiment 2, intake of the ice cream was greater after active drug administration because subjects who received active drug on the first session ate less ice cream in the placebo session. In conclusion, in the short term, naltrexone had no impact on hunger, sensory-specific satiety or food intake.

Adolescent

Decrease in resting metabolic rate during abstinence from bulimic behavior.

Among eight normal-weight bulimic women studied during 1 week of binge eating and vomiting and 7 weeks of abstinence without weight loss, resting metabolic rate and T3 and T4 levels fell significantly during abstinence. These data suggest that a physiological consequence of binge eating and vomiting is an increase in metabolic rate, in part due to increased thyroid hormone activity.

Adult