The genetics of a mutable gene at the white locus of Drosophila melanogaster.
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Biomedical subjects
Publications and source records attributed to M M Green.
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The failure to diagnose hypothermic and hyperthermic states can have profound clinical implications. Thus, accurately determining body temperature is an integral component of the evaluation of all emergency department (ED) patients. Oral measurements are most commonly obtained but may not reflect core temperatures. Rectal temperatures are considered more reliable but may not reflect fluctuating core temperatures, and are dependent on site placement. The objective of this study was to determine the practicality and comparative accuracy of tympanic thermographic measurements in the ED. Oral, rectal and tympanic readings were compared in 411 patients. There were significant differences when comparing tympanic to oral (R2 = 0.599, P = 0.0001) and rectal to oral (R2 = 0.554, P = 0.0001) temperatures. In contrast, the correlation between tympanic and rectal measurements was R2 = 0.805, with no significant difference between the two, (P = 0.7077). No complications associated with the use of the tympanic probe were detected. Infrared tympanic thermography is an efficient and noninvasive technique for accurately measuring the temperature of ED patients.
Abdominal pregnancy is such an unusual form of ectopic gestation that the diagnosis is often missed or delayed. We report three cases, each with a different clinical presentation. A careful history and evaluation in the Emergency Department (ED), along with liberal and timely use of ultrasonography, are critical for prompt diagnosis and treatment. Features such as abdominal pain inconsistent with a previous presumptive diagnosis, or repeated ED visits, in a patient with a positive beta-HCG test, are suggestive of this diagnosis.
A total of 34 third chromosomes of Drosophila melanogaster that render homozygous larvae hypersensitive to killing by chemical mutagens have been isolated. Genetic analyses have placed responsible mutations in more than eleven complementation groups. Mutants in three complementation groups are strongly sensitive to methyl methanesulfonate, those in one are sensitive to nitrogen mustard, and mutants in six groups are hypersensitive to both mutagens. Eight of the ten loci mapped fall within 15% of the genetic map that encompasses the centromere of chromosome 3. Mutants from four of the complementation groups are associated with moderate to strong meiotic effects in females. Preliminary biochemical analyses have implicated seven of these loci in DNA metabolism.
Of 51 visible mutants isolated from natural or laboratory populations of Drosophila buzzatii, or X-ray induced, 42 have been assigned to chromosomes, and linkage maps have been constructed. About half of the autosomal mutants map to chromosome 2, with only two on chromosome 3 and none on chromosome 4. For the whole repleta group, chromosome 2 also exhibits much greater inversion variability than other chromosomes, which suggests variation among chromosomes in apparent mutability. The chromosomes of D. buzzatii are homologized to those of D. melanogaster and to the standard chromosomal elements of Drosophila. Sequence comparisons for six X chromosome mutant genes, whose homology is reasonably certain, in 13 Drosophila species confirm linkage group conservation but great variation among species in gene order. The linkage group conservation of single-copy genes stands in contrast to observed transpositions between elements for tandem repeat genes.
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