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Biomedical subjects

M M Goldsmith

Publications and source records attributed to M M Goldsmith.

24 records · Page 2Linked to original sources
PubMed1987

Presentation and management of postcricoid hemangiomata in infancy.

Phillips and Ruh (1912) were the first to describe a congenital hemangioma of the larynx. Sweetser subsequently classified laryngeal hemangiomata into infantile and adult types and noted differences in incidence, location, and symptoms. According to Sweetser, the infantile form is less common, is almost always subglottic, and presents with stridor which may be intermittent. The adult form is somewhat more common, is generally supraglottic, and often presents with hoarseness or dysphagia. We present what we believe is the first reported case of a postcricoid hemangioma in an infant. A review of hemangiomata of the aerodigestive tract is presented and treatment is discussed.

Cricoid Cartilage↗
PubMed1986

Significance of ploidy in laryngeal cancer.

We studied 48 patients with laryngeal or hypopharyngeal primary tumors with DNA flow cytometry. Twenty-four of the tumors were glottic, 18 were supraglottic, and 6 were from the pyriform sinus. Patients were followed for a minimum of 12 months, with a mean follow-up of 23 months. Twenty-three of the 48 primary tumors (48 percent) were clearly aneuploid, 22 percent were tetraploid, and 30 percent were diploid. We concluded that patients with aneuploid primary tumors, high DNA levels, or both have a significantly better prognosis than those with diploid tumors, and this remained statistically significant when clinical outcome was adjusted for tumor status, stage, and nodal status.

DNA, Neoplasm↗
PubMed1986

The surgical exposure of penetrating injuries to the carotid artery at the skull base.

Injuries of the internal carotid artery at the skull base present complex technical problems for the surgeon. Exposure is difficult, distal control of the vessel for shunting or repair is frequently impossible, and thus ligation of the ICA is often necessary as definitive treatment. Three cases involving penetrating injury to the carotid artery at the skull base are presented. The issue of primary repair vs. ligation for carotid injuries is briefly addressed, and the various methods of surgical exposure of the distal extracranial ICA are reviewed.

Adult↗
PubMed1982

Exchange transfusion with Fluosol 43: in vivo assessment of cerebral cytochrome c oxidase redox state.

Rats were serially exchange transfused to hematocrits less than 2% (50-cc exchange) with either Krebs-Henseleit-albumin (KHA) solution or Fluosol-43 (F-43). Reflectance spectrophotometry was employed to monitor cerebral cytochrome c oxidase redox states. Determination of mean arterial pressure (MAP), arterial and venous oxygen content difference (A-VO2), and cerebral cortical ATP and lactate concentrations were also made. As hemodilution progressed, neither solution provided normal quantities of oxygen as evaluated by the cytochrome c oxidase redox state and a decrease in A-VO2 difference, although F-43 was significantly (p less than 0.01) better than KHA in terms of cytochrome c oxidase redox state as well as maintenance of MAP. There was no significant difference between the two test solutions in terms of cortical ATP and lactate.

Adenosine Triphosphate↗