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M M Fomina

Publications and source records attributed to M M Fomina.

14 recordsLinked to original sources
PubMed1988

[Comparative evaluation of the antitumor, cytogenetic and immunodepressive effects of dimetinur when used perorally and parenterally].

The dimethylnitrosourea action after oral and parenteral administration was comparatively evaluated on the basis of criteria for the antitumour and cytogenetic activity, as well as for the immune (T-cell) reactivity of tumour-bearing and intact animals. A considerable antitumour effect and the induction of the overload chromosomal aberrations in tumour cells with the complete preservation of bone marrow cells were observed during the oral drug application. Dimethyl nitrosourea-induced T-cell depression in murine spleen was transitory and reversible. Thus the oral administration of the drug was shown to be optimal for realization of its therapeutical activity with the least toxic side effect on the host normal hemopoietic and immunocompetent cells.

Administration, Oral↗
PubMed1986

[Dynamics of the chromosomal damages to Ehrlich ascitic cancer and bone marrow cells of mice by the antitumor preparation dimetinur].

The dimetinur effect upon chromosomes of the Ehrlich ascite carcinoma and bone marrow cell populations was analyzed by the cytogenetic method for 10 days after i.p. and i. v. drug administration in doses from 50 to 150 mg/kg. Kinetic regularities of changes in a fraction of cells with chromosome breakages and in the number of broken chromosomes per cell as well as "dose-effect" relations are determined. A linear correlation is established between the level of residual chromosome damages in a population of tumour cells and the coefficient of activity chi* characterizing the antitumour effect of dimetinur. Selectivity of the dimetinur mutagenic action expressed as a more deep and prolonged damage of the genetic system of tumour cells as compared to bone marrow cells of tumour-bearing animals is shown under conditions of a pronounced therapeutic activity.

Animals↗
PubMed1979

[Polymorphism of a tumor cell population and selective processes. III. A change in the correlation of tumor cell subpopulations of the ascitic strain of Ehrlich-I.Ch.Ph. under the influence of glucose and sodium succinate].

A study was made of the action of glucose or sodium succinate on subpopulations of the Ehrlich-I.Ch.Ph. ascite strain characterised by markers "A1" and "A", resp. After i.p. injection of glucose the amount of "A1"-cell reached 50 and almost 100% on the 5th and 7th day of tumor growth. After the transplantation of "A1"-cells into intact animals, a homogenous cytogenetic feature of subpopulation persisted during 2 passages only. Kinetics studies of a subvariance of the Ehrlich-I.Ch.Ph. tumor containing "A1"-cells show that the tumor growth rate and grade of malignancy slightly differ from those seen in the controls.

Animals↗
PubMed1979

[Polymorphism of a tumor ce-l population and selection processes. IV. The effect of dibunol and nitrosourea on the variability of Ehrlich-I. Ch. Ph. ascitic strain tumor cells].

A study was made of the effect of dibunol and methyl-N-nitrosourea (MNU) on two tumor cell subpopulations of the Ehrlich-I. Ch. Ph. ascites strain, one of which is characterized with A + B + 2C and A + D + 2C--markers and the other one--with A1 + A2 + 2B + D + C markers. Dibunol that belongs to the class of inhibitors of free-radical processes was shown to bring about changes in cell subpopulations, the mode of changes depending on the dose and regime of treatment. The effect of MNU on the population resulted predominantly in the accumulation of cells with various chromosome aberrations. At early stages of tumor progression, aberrations were more pronounced in cells with marker chromosome "A" than in the cells with 44 chromosomes and markers A1 + A2 + 2B + D + C.

Animals↗
PubMed1978

[Polymorphism of a population of tumor cells and selective processes. I. Ehrlich-IChPh ascitic strain tumor cell subpopulation].

4 types of marker chromosomes and of their combination in mouse ascite Ehrlich-I. Ch. Ph. tumor cells are described. Two most frequently encountered subpopulations of cells are found in the tumor: one--with A+B+2C and A+D+2D markers, and the other--with A1+A2+2B+D1+C markers. The former population dominated during 8 days, to be gradually substituted with the former subpopulation. Changes in the number of cells with certain chromosome number in the near-diploid and near-tetraploid cell zones were followed within one passage.

Animals↗
PubMed1978

[Polymorphism of a tumor cell population and selective processes. II. Change in the correlation of the numbers of 2 subpopulations of Ehrlich-Ich Ph ascites tumor cells in mice under the action of cell-free ascitic fluid and its fractions].

After repeated injections to mice of cell-free fluid the inhibition of growth of ascitic cell number was noticed already on the 5th day after transplantation of tumor. It was found that the inhibition of growth was due to the death of cells having 45 chromosomes, and containing A + B + 2C- and A + D + 2C-markers.

Animals↗
PubMed1975

[Cytogenetic characteristics of the growth of mouse ascitic strain L-5178].

The number of chromosomes in the cells of L-5178 ascites tumor vary from 38 to 46. The modal class consists of two cell lines with 43 and 44 chromosomes. The number of polyploid cells changes in the process of tumor growth from 11% within first 10 days after transplantation to 50% on the 21st-22en days. The tumor cell population manifests a number of metaphases with endoreduplication of chromosomes. The per cent of metaphases with diplochromosomes varies from 0.05% on the 7th day of tumor development to 5.0% on the 15th-17th day. L-5178 tumor cells are characterized by the presence of structurally changed chromosomes: the acrocentric chromosome with the secondary constriction, metacentric, and 2-3 small chromosomes.

Animals↗
PubMedDate not supplied

[Adaptation to chemical mutagens].

Pre-adaptation of normal and tumor cells to the action of methylnitrosourea was studied. To attain these ends, a single low dose (10 mg/kg) was administered to animals two hours prior to the administration of main therapeutic dose (100 mg/kg) and the number of chromosomal rearrangements was determined. A significant decrease in translocation incidence was observed in metaphases of Ehrlich-ICP ascitic strain. Similar results were obtained on cells of murine bone marrow. The mechanisms of pre-adaptation to the action is discussed.

Abdominal Neoplasms↗
PubMedDate not supplied

[The dose-dependent cytogenetic and growth-inhibiting effects of a new antitumor preparation from the nitrosourea group].

Kinetics of growth-inhibiting and cytogenetic effect of a new carbon-substituted nitrosourea derivative (ADEKO) has been studied in a wide dose range. A linear dose-effect dependence was observed. The level of damaged cells in a population is connected with a number of chromosomal aberrations per cells with a semilogarithmic dependence. The drug has a pronounced clastogenic effect that reveals itself in total damaging of chromosomal structure of tumor cells. It also causes cell polyploidization with the increase in does and duration of action. Chromosomal aberrations induced by the drug are observed in the tumor long after the action of the drug and their level correlates positively with antitumor activity of ADEKO. ADEKO damages preferentially tumor cells as compared to bone marrow.

Animals↗