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Biomedical subjects

M M Fisher

Publications and source records attributed to M M Fisher.

At least 37 records · Page 2Linked to original sources
PubMed1997

Health service reform: the perceptions of medical specialists in Australia (New South Wales), the United Kingdom and New Zealand.

OBJECTIVE: To examine the effect of recent healthcare service changes (including significant resource constraint and a greater role for the non-medical manager) in the United Kingdom, Australia and New Zealand on medical specialists' perceptions of their healthcare organisation goals and service delivery, and their enthusiasm for their work. DESIGN: Postal questionnaire survey, answered anonymously. PARTICIPANTS AND SETTING: Medical specialists employed either part- or full-time in two United Kingdom National Health Service Trusts (one acute, one mental health/community service), an Australian Area Health Service and a New Zealand Crown Health Enterprise in 1995. MAIN OUTCOME MEASURES: Participants' rating of their knowledge of employers' organisational goals, ability to influence management, perceptions of changes in resources and service availability since 1990 and changes in enthusiasm for their work over the past four years. RESULTS: 369 of 521 eligible specialists responded (71%); by country-United Kingdom, 123/186 (66%); New Zealand, 123/160 (77%); Australia, 123/175 (70%). New Zealand specialists were less aware of their employers' organisational goals and had less congruence between these and their own personal goals than United Kingdom or Australian specialists (P < 0.05). Interest in influencing central management was similar in the three countries, but Australian specialists felt management was less likely to follow their advice compared with United Kingdom specialists (P < 0.05). New Zealand specialists perceived that waiting times for non-urgent patients were currently longer than in 1990 compared to United Kingdom specialists (P = 0.02). In all three countries, inpatient beds were perceived to be less available than in 1990, but less so in New Zealand. The ease of replacing equipment was better in New Zealand than in Australia and the United Kingdom (P = 0.00001). More than 50% of participants in all three countries (183/361; 50.7%) reported that their enthusiasm for their work had decreased in the past four years. CONCLUSION: The effects of health service reforms seem to have reduced enthusiasm for work among medical specialists in Australia, the United Kingdom and New Zealand.

Attitude of Health Personnel↗
PubMed1997

Critical care. A specialty without frontiers.

During its development, the specialty of Intensive Care has evolved from simple supportive ventilatory techniques to complex monitoring and decision making. The evidence suggests that a trained dedicated intensivist has beneficial effects on outcomes and costs compared to open units. The role of the intensivist and the need for interaction with other groups is discussed.

Critical Care↗
PubMed1997

Intradermal compared with prick testing in the diagnosis of anaesthetic allergy.

We have tested the hypothesis that intradermal testing is a more effective method for determining the drug responsible for anaesthetic anaphylactic reactions than prick testing in 212 consecutive patients, aged more than 10 yr, referred to an anaesthetic allergy clinic over a 4-yr period. The study was a prospective, non-randomized design. Intradermal testing was conducted using a previously described method and diluted drugs, and prick testing using undiluted drugs (with the exception of opioid analgesics which were diluted 1:10). The tests were performed on individual patients' forearms on the same occasion. Patients were followed-up to determine the results of subsequent anaesthesia and the difference between tests was analysed using kappa and tau statistics. There was 93% agreement overall between the paired tests. Which test detected the drug responsible was dependent on diagnostic criteria for positivity. The differences between the tests were not statistically significant. Using both tests improved predictability by 67% (tau = 0.67, P < 0.001). We conclude that in the absence of data to support one test being superior, other factors influence the choice of test. Prick testing was cheaper, and the reduction in pain and trauma with prick testing makes it more suitable for children. However, there are no data available on the safety of subsequent anaesthesia based on the results of prick testing alone, and reliability with time has not been assessed. Intradermal testing may be easier for the infrequent user. Skin testing is valuable in the investigation of anaesthetic anaphylaxis whichever test is chosen. When there is doubt both tests should be performed.

Adult↗
PubMed1997

Alleged allergy to local anaesthetics.

The aim of this study was to determine the incidence of true local anaesthetic allergy in patients with an alleged history of local anaesthetic allergy and whether subsequent exposure to local anaesthetics is safe. Two hundred and eight patients with a history of allergy to local anaesthesia were referred over a twenty-year period to our Anaesthetic Allergy Clinic. In this open study, intradermal testing was performed in three patients and progressive challenge in 202 patients. Four patients had immediate allergy and four patients delayed allergic reactions. One hundred and ninety-seven patients were not allergic to local anaesthetics. In 39 patients an adverse response to additives in local anaesthetic solutions could not be excluded. In all but one patient local anaesthesia has been given uneventfully subsequently. A history of allergy to local anaesthesia is unlikely to be genuine and local anaesthetic allergy is rare. In most instances LA allergy can be excluded from the history and the safety of LA verified by progressive challenge.

Adolescent↗
PubMed1996

Physician recognition of hypochondriacal patients.

To examine primary care physician recognition of hypochondriacal patients, we identified a series of such patients in a general medicine clinic using the Whiteley Index. Clinic physicians made blind global ratings of severity of physical disease and unreasonable fear of illness (hypochondriasis) and completed a checklist of somatizing characteristics. Patient records were audited for diagnoses, laboratory tests, consultations, and medications prescribed. Twenty-nine (14%) of 210 patients scored above an established cutoff on the Whiteley Index. These hypochondriacal patients were rated by clinic physicians as more hypochondriacal and were more often given psychiatric diagnoses. Also, clinic physicians identified more somatizing features among hypochondriacal patients including their own reaction to them. This recognition of hypochondriac characteristics may have contributed to better management but may need to be raised to the diagnostic level for maximum benefit.

Adult↗
PubMed1995

Development, implementation, and evaluation of a health promotion program in a college setting.

The authors developed, implemented, and evaluated a health promotion program for employees at a state college in New Jersey on the basis of a campus health survey. The resulting physical fitness and exercise program with educational components was assessed twice. Comparisons of experimental and control groups, using one-way analyses of variance, revealed significant differences on four variables: high-density lipoprotein (HDL), total cholesterol/HDL ratio, triglycerides, and body weight in pounds.

Analysis of Variance↗
PubMed1995

Pilot trials of PDF symbology as a means of transfering data on blood units between transfusion centres.

PDF 417, a two-dimensional barcode, was used as a portable data file to transfer key information on blood units and delivery documentation between two Regional Blood Transfusion Centres. Multiple Codabar messages currently displayed on blood packs, as well as other useful information, i.e. microbiology conformance, were encoded in a 45-character single PDF barcode. The delivery note which accompanied each consignment of blood consisted of a series of PDF barcodes, each representing 20 blood units. Computer validation showed 100% reconciliation of PDF data with Codabar data. Readability of the code was excellent with a greater than 98% first-pass read rate. The delivery note PDF barcode identified eight operator errors which would have been undetected by the present manual system. We conclude that PDF 417 is an effective, secure and space efficient means of transferring data associated with the transfer of blood.

Blood Banks↗
PubMed1995

The impact of heat and moisture exchanging humidifiers on work of breathing.

In this study the resistive work or breathing (WOB) associated with eleven commercially available heat and moisture exchangers (HMEs) was evaluated for gas flow rates of 20 to 60 l.min-1. The Gibeck Humid-Vent 2S Flex was also assessed after 24 hours patient usage (n = 50). The WOB associated with these devices was compared with that of standard endotracheal tubes and standard humidifying circuits with flex-tube connectors. The range of work imposed by the eleven HMEs approximated the range shown by water bath circuitry when used with two different commonly used flex-tube connectors. The excess WOB attributed to the HMEs was significantly less than that imposed by standard endotracheal tubes. After 24 hours of patient use, 96% of the Gibeck HMEs tested demonstrated a resistive WOB within the range of the two flex-tube connectors. To assess the clinical significance of this circuit-related WOB, we compared respiratory variables in 40 patients breathing on either CPAP or pressure support ventilation, using a variation in flex-tube resistance which imposed a range of WOB comparable to that shown by the HMEs. A small but statistically significant reduction was found for both the peak flow (48 +/- 1.4 vs 45 +/- 1.1 l.min-1, P < 0.0005) and the minute volume (8.6 +/- 0.35 vs 7.9 +/- 0.31, l, P < 0.0005). These data suggest that the range of resistive work imposed by commercially available HMEs has a small but potentially significant effect on clinical respiratory parameters.

Airway Resistance↗
PubMed1994

Psychiatric comorbidity among patients with hypochondriasis.

The purpose of this study was to determine the nature and extent of comorbidity among patients with DSM-III-R hypochondriasis and to examine the relationships between this disorder and coexisting psychiatric illness. For this purpose, patients seen in a general medicine clinic were screened using measures of hypochondriacal attitudes and somatic symptoms. Those scoring above an established cutoff were given a structured diagnostic interview. In this manner, 50 patients who met DSM-III-R criteria for hypochondriasis and 50 age- and sex-matched controls were identified. The presence of other psychiatric disorders (current and past) was determined by means of the same diagnostic interview. More hypochondriacal subjects (62.0%) had lifetime comorbidity than did controls (30.0%). Major depression, the most frequent comorbid disturbance, was usually current and most often had an onset after that of hypochondriasis. Panic disorder with agoraphobia, the most frequent anxiety disorder, was also current but often began before or at the same time as hypochondriasis. Few subjects met criteria for somatization disorder but a third qualified for a subsyndromal form of this disorder. The data show that, in medical outpatients with hypochondriasis, mood and anxiety disorders frequently coexist. This comorbidity is subject to varying interpretations including overlap of symptom criteria, treatment-seeking bias, and the possibility that hypochondriasis predisposes to or causes the comorbid disorder, as seems likely in the case of depression. In some instances hypochondriasis may be an associated feature of another illness.

Adult↗
PubMed1994

Cost containment: the Pacific. Australia.

In Australia, as in other countries, recession has accelerated government efforts to reduce the costs of health care. A variety of strategies have been introduced in different states. Cost-cutting measures have improved efficiency but have impacted patient care, particularly in the areas of new technology and high-cost drugs.

Australia↗
PubMed1993

The validity of DSM-III-R hypochondriasis.

BACKGROUND: Because of the uncertainty about the status of hypochondriasis, the disorder is rarely diagnosed. To address this problem we examined the validity of DSM-III-R hypochondriasis as identified by structured interview. METHODS: Patients in a general medicine clinic were screened for hypochondriacal attitudes and symptoms. Those patients who scored above an established cutoff had a structured diagnostic interview, and 50 patients who met DSM-III-R criteria for hypochondriasis and 50 age- and sex-matched controls were thus identified. Information was obtained from both groups on health perceptions, health care utilization, and level of functioning using self-report and physician-rated measures. Additional information on diagnoses and treatment recommendations was obtained from record audits. RESULTS: Clinic physicians rated hypochondriacal subjects as having more unrealistic fear of illness (hypochondriasis) and diagnosed psychiatric and functional somatic syndromes more frequently in hypochondriacal than in control subjects. Hypochondriacal subjects viewed their health as worse, had more health worries, and had more severe psychiatric symptoms than control subjects. They also reported poorer physical functioning and work performance, greater health care utilization, poorer response to medical treatment, and less satisfaction with the care received than controls. CONCLUSIONS: Results show that, although the diagnosis of hypochondriasis is rarely made, physician recognition is high. They also show that several indicators of internal and external validity of this diagnostic category exist. Findings suggest that if physicians are to reduce the functional impairment and nonproductive health care utilization of these patients, they will need to make the diagnosis of hypochondriasis and intervene appropriately. However, for this to occur, research demonstrating predictive validity and treatment responsiveness of the disorder will be required.

Adult↗
PubMed1993

Microencapsulation of viable hepatocytes in HEMA-MMA microcapsules: a preliminary study.

Viable rat hepatocytes were encapsulated in a HEMA-MMA copolymer (80% HEMA). Encapsulated hepatocytes continued to produce urea (a measure of viability) for approximately 2 wk although urea production rates fell steadily over the course of in vitro culture in a pattern similar to those of control hepatocytes in conventional culture. Urea production was slightly higher in 0.01 M Tris buffered glycerol precipitated capsules, relative to phosphate buffered saline precipitated capsules. Hepatocytes were not viable in 0.001 M Tris buffered glycerol precipitated capsules which had a dense wall without the macroporosity seen in the walls of the other capsules. More work is needed to show that HEMA-MMA encapsulated hepatocytes retain some of the differentiated functions of hepatocytes.

Animals↗
PubMed1993

The incidence and clinical features of anaphylactic reactions during anesthesia in Australia.

The details of 826 patients referred to an Anaesthetic Allergy Clinic over a 17-year period are described. 443 were classified as having severe immediate anaphylactic reactions and in the majority of these (263) a muscle relaxant was involved. In Australia, the most common cause of a reaction is alcuronium, which probably reflects usage, although it is the most commonly found to give a positive skin test in relaxant reactors. Suxamethonium and atracurium appear to have an incidence of reactions greater than predicted by market share and pancuronium and vecuronium appear safer both on incidence of reactions and on positive skin tests in reactors. The incidence of reactions is between 1:10,000 and 1:20,000 anaesthetics. Patients who react have greater incidence of allergy, atopy, asthma and previous reactions than non reactors. Previous exposure is usually apparent in reactors to induction agents but not muscle relaxants. Cardiovascular collapse is the most common presenting problem and is the only problem in 10%. Skin changes are the next most common and then bronchospasm which may be transient and is the hardest feature to treat. With an investigation protocol based on history, skin and RIA testing subsequent anaesthesia is usually safe.

Anaphylaxis↗
PubMed1993

Mechanisms in IgE-dependent anaphylaxis to anesthetic drugs.

The discovery of IgE antibodies to neuromuscular blocking drugs, to thiopentone and narcotics, particularly morphine, reinforced earlier beliefs formed from skin test and other clinical findings that many "anaphylactoid" reactions to drugs were true type 1 immediate hypersensitivity reactions. Immunochemical studies established the fine structural specificities of the drug-reactive IgE antibodies and provided an explanation in molecular terms for a number of observed clinical cross-reactions. Subtleties in interpreting relationships between skin tests and IgE radioimmunoassays are pointed out and mechanisms of drug-induced mediator release, persistence of IgE antibodies and the nature of the sensitizing sources are discussed.

Anaphylaxis↗