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Biomedical subjects

M M Beyer

Publications and source records attributed to M M Beyer.

30 records · Page 2Linked to original sources
PubMed1977

Immune competence of the streptozotocin-induced diabetic rat. I. Absent second-set skin allograft response.

A study was designed to assess the cellular immune competence of Lewis rats with streptozotocin-induced diabetes. First-set Fischer skin allografts were rejected in 10.9 days by nondiabetic Lewis recipients and in 12.0 days by diabetic Lewis recipients. Second-set skin allografts in the same strain combination, utilizing the same recipients, were rejected in 8.1 days by nondiabetic recipients and in 13.0 days by diabetic recipients (P less than 0.01), indicating an absence of second-set rejection in the streptozotocin-induced diabetic rat. Treatment with NPH insulin, 3 units daily, although only slightly corrective of hyperglycemia, reduced second-set graft rejection to 8.0 days. These findings offer evidence of impaired cellular immune responsiveness in the streptozotocin-induced diabetic rat. Insulin was shown to correct deficient allograft immunity.

Animals↗
PubMed1977

Islet of Langerhans allotransplantation in the rat.

Normoglycemia in rats allotransplanted with islets of Langerhans was studied. It was found that pretreatment with donor liver extract and pertussis followed by a short course of ALS treatment results in much better overall survival of functioning islets of Langerhans allotransplants than with other forms of immunosuppression tested.

Animals↗
PubMed1975

Epsilon-aminocaproic acid in traumatic renal hematuria in the rabbit.

Epsilon-aminocaproic acid (EACA) was intravenously administered to rabbits subjected to bilateral renal crushing trauma. Posttraumatic hematuria in 10 control rabbits lasted a mean of 5.5 days (range 5 to 7 days). Rabbits treated with 1250 mg 5 min before renal trauma and with repeat EACA injections 1 hr (500 mg) and 24 hr (500 mg) after the injury had significantly less hematuria. Only eight of 20 EACA-treated rabbits had any hematuria, and this bleeding terminated by the 2nd posttrauma day in all. EACA may have an important role in the management of trauma-induced renal bleeding.

Aminocaproates↗
PubMedDate not supplied

Adverse impact of hypertension on diabetic recipients of transplanted kidneys.

The effect of hypertension on patient and allograft survival in 60 diabetic recipients of transplanted kidneys was assessed by retrospective chart analysis. Hypertension was present in 81% of recipients. Of eight of these patients who became normotensive after transplantation, all had functioning allografts and one died. By contrast, persistent hypertension after transplantation was associated with a higher mortality rate (25 of 54, 48%) and loss of kidney graft function (19 of 54, 35%). At a mean of 21 months after transplantation, living hypertensive diabetic recipients had worse renal function (mean serum creatinine of 3.1 mg/dl) than did nonhypertensive recipients (mean serum creatinine of 1.6 mg/dl). It is concluded that hypertension is a significant risk factor for diabetic patients and kidneys after transplantation.

Aged↗