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Biomedical subjects

M Lutz

Publications and source records attributed to M Lutz.

134 records · Page 8Linked to original sources
PubMedDate not supplied

Quality of life after permanent prostate implant.

Quality of life is one of several endpoints commonly studied in prostate cancer treatment. It refers to how well an individual is functioning in life and his total sense of well being. There is increasing recognition that cancer therapy impacts significantly on the patient's ability to pursue relational, occupational and social interests. Fifty-one patients with clinically localized prostate cancer who had undergone transperineal permanent prostate implantation were evaluated. All patients were clinically staged as T1c or T2a and received an implant alone with Iodine 125 or Palladium 103 as definitive treatment. Six months after implant, data was collected using the European Organization for Research and Treatment of Cancer (EORTC) genitourinary group questionnaire and supplemental questions. Urinary symptoms such as nocturia, hesitancy, frequency, and dysuria were the most pronounced in the first few months after the implant and then decreased in most of patients; 40% noticed that they urinated more frequently and 17% had mild dysuria. All patients denied hematuria and none reported incontinence. Few patients reported any psychological distress or disruption in social or family life; none reported disruption in economic status or viability. All fifty-one patients said that they would have an implant again as definitive treatment. Seventy-nine percent reported an excellent quality of life post-implant. While survival is clearly a central goal of treatment for prostate cancer, the nature of this malignancy compels clinical attention to the quality of the patient's life after treatment. Sexual quality and function are maintained in the majority of patients and there is minimal interruption of their social and economic function.

Brachytherapy↗
PubMedDate not supplied

Resonance Raman spectroscopy of chlorophyll-protein complexes.

Resonance Raman spectra of chlorophyll a (Chl a) and of Chl b were selectively obtained, at low temperature, from chlorophyll-protein complexes prepared from green and blue-green algae and from higher plants. Antenna Chl a in the Chl a-P700-protein complexes (CP I) and in the light-harvesting Chl a/b-protein complexes (CP ii gives resonance Raman spectra extremely close in all their features to those previously obtained from intact cells and chloroplasts. In particular, the same multiplicity of binding sites for the ketone carbonyl groups of Chl a is observed in both CP I and CP II as in intact membranes. These bindings sites are probably the same types as those observed in the intact membranes and are not the magnesium atoms of other chlorophylls. The magnesium atoms of most Chl a molecules in both CP I and CP II bind a single external ligand. Resonance Raman spectra of Chl b in CP II preparations, although very similar to those from intact membranes, show partial rearrangement of one of the two environmental subspecies of Chl b previously found in intact membranes. These results provide evidence that chlorophyll-protein complexes closely represent the state of the bulk of antenna chlorophyll in vivo.

Binding Sites↗
PubMedDate not supplied

Disruption of the finger flexor pulley system in elite rock climbers.

We treated 13 elite rock climbers for isolated disruptions of the pulleys of the long fingers. Diagnosis and treatment were based on the clinical finding of bow-stringing, which was confirmed by magnetic resonance imaging. Eight patients had bowstringing indicating incomplete disruption of the major pulley A2 and were treated nonoperatively (group A). Five patients showed bowstringing indicating complete disruption of the pulley A2. After failed nonoperative treatment, the pulleys were reconstructed (group B). The mechanism of injury and clinical and subjective results were evaluated. At a 31-month follow-up (range, 18 to 43 months), loss of extension in the proximal interphalangeal joint measured 5.6 degrees (range, 0 degree to 10 degrees) in group A and 4 degrees (range, 0 degree to 10 degrees) in group B. Circumference of the finger section was increased 4.2 mm in group A (range, 0 to 10 mm) and 4.8 mm in group B (range, 0 to 10 mm). Grip strength decreased 20 N in group A (range, 10 to 50 N) and 12 N in group B (range, 10 to 30 N). Four patients in group A and one in group B had bowstringing at clinical evaluation. On follow-up magnetic resonance images, bowstringing remained unchanged in group A but was reduced in all patients in group B. Good subjective results were seen in both groups.

Adult↗