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Biomedical subjects

M Lunding

Publications and source records attributed to M Lunding.

7 recordsLinked to original sources
PubMed1978

Serum diazepam and serum creatine kinase after intra-muscular injection of diazepam in two different vehicles.

Serum diazepam concentration and serum creatine kinase activity (serum CK) were measured in 35 patients (who were divided into three groups (A, B, and C)), over a period of 24 hours after administration of diazepam. An increase in serum CK was regarded as an indication of local muscle injury. In group A, diazepam in a polyethyleneoxydricinolate vehicle was injected intramuscularly; in group B, diazepam in a propyleneglycol-ether alcohol vehicle was injected intramuscularly; and in group C, diazepam was administered orally, combined with intramuscular administration of the vehicle used in group B. The investigation was double-blind and randomized. Serum diazepam absorption expressed as the area under the concentration curve was identical in groups A and C and significantly higher than in group B. Serum CK rose in all groups. The differences among the groups were not significant. There were considerable individual variations in all three groups, and almost half the patients showed no increase in serum CK at all. No negative correlation was found between serum diazepam and serum CK. Thus no effect of muscle injury--if present--on absorption rate could be demonstrated.

Administration, Oral↗
PubMed1978

Two early Danish respirators designed for prolonged artificial ventilation.

Two Danish respirators are described. The first one was made by August Krogh in 1931 and was based on the principles of the Drinker tank respirator. The original feature was a motor driven by water from an ordinary water tap. It was never widely used, most likely due to practical problems connected with nursing care, etc. The polio epidemic in Copenhagen in 1952 initiated the era of the IPPV-methods and gave rise to the construction of a great number of new respirators. Among the first of these was the Claus Bang respirator. Although it contained many modern features, it proved technically unreliable and was only used for 3-5 years.

Denmark↗
PubMed1976

Cardiovascular effects of induced hypercarbia during halothane-nitrous oxide anaesthesia.

The effect of induced hypercarbia on the cardiovascular system during steady-state halothane-nitrous oxide anaesthesia was investigated in 4 male patients without cardiac disease. Heart rate, cardiac index, systemic and pulmonary blood pressures rose as pCO2 was increased. Stroke volume, systemic and pulmonary vascular resistance remained unchanged. Oxygen consumption decreased and oxygen saturation of mixed venous blood increased. In conclusion the primary effect of hypercarbia was an increased heart rate and a resultant increase of cardiac output. The pressure changes merely reflect the effect on cardiac output. Under these circumstances a regulatory role of mixed venous pO2 on cardiac output is highly unlikely.

Aged↗
PubMed1975

Tricyclic antidepressive poisoning with special reference to cardiac complications.

Sixty-eight cases of tricyclic antidepressive (TCA) poisoning are discussed. Cardiac arrest occurred in 8 patients, preceded by minor ECG-abnormalities. Five patients died. All cardiac arrests arose within the first 24 h after TCA ingestion. Fifty-seven patients developed ECG-abnormalities, of which 84% began within the first 6 h after TCA ingestion. ECG-abnormalities and other symptoms (respiratory arrest, coma, convulsion and hypotension) often occurred in the same patients. Treatment is described, and cardiac monitoring for at least the first 24 h is recommended. In cases of severe cardiac (ECG) abnormalities, monitoring is recommended until no ECG abnormalities are observed for at least 12 h. In conclusion, the unrestricted use of TCA is cautioned against, since TCA must be regarded as potentially cardiotoxic.

Adolescent↗