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Biomedical subjects

M Luciak

Publications and source records attributed to M Luciak.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Histopathological studies of connective tissue in patients with acquired valvular heart disease.

Tissue samples taken during a surgical procedure performed for therapeutic reasons in 27 patients with acquired valvular heart disease (a.v.h.d.) were subjected to histopathological examinations. The aim of the work was to carry out simultaneous studies of several organs in the same patients. The samples were taken from: left heart auricle (15 cases), heart valves (15 cases), palatine tonsils (10 cases), subcutaneous tissue (14 cases) and periodontium (9 cases). Out of the total number of 27 cases samples from 5 organs of the same person were examined once, from 4 organs twice, from 3 organs twelve times, and from 2 organs fifteen times. In 90% of cases marked qualitative and quantitative compatibility between histopathological pictures of connective tissue changes was found. These changes consisted in an increased number of collagen fibres and hyalization of connective tissue. The authors conclude that infective endocarditis could be in connection of a primary general collagenopathy.

Adult↗
PubMedDate not supplied

Effect of morphine and naloxone on oxidative metabolism during experimental renal ischemia and reperfusion.

During experimental renal ischemia and reperfusion in rabbits, morphine as well as naloxone significantly inhibited the increased superoxide anion (O2-) generation by resting and opsonized zymosan-stimulated phagocytes in renal venous blood. Morphine with naloxone in combination inhibited O2- generation to a lesser extent than that observed when these drugs were used separately. Morphine and/or naloxone did not significantly affect erythrocyte superoxide dismutase (SOD-1), glutathione peroxidase (GPx) and catalase activities or malonyldialdehyde (MDA) concentrations in venous blood during renal ischemia. During reperfusion there was a tendency to a slight reduction of erythrocyte catalase activity in morphine-treated animals, and to slight diminutions of erythrocyte SOD-1 and GPx activities and erythrocyte MDA concentrations in rabbits treated with naloxone and morphine in combination. These results indicate that opioid receptor agonists and antagonists modify the response of the kidney to acute injury. These effects may have relevance to the pattern of oxidative stress seen in patients with acute ischemic renal failure.

Acute Disease↗