The Laurence-Moon-Biedl-Bardet syndrome. Report of three cases in a Jewish Yemenite family.
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Biomedical subjects
Publications and source records attributed to M Lotem.
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Spontaneous osteonecrosis (ON) of the medial tibial plateau was diagnosed in 15 elderly patients (21 knees). The onset was characterized by sudden severe medial knee pain, usually with an effusion. Radiographic changes suggestive of ON occurred medial to the weight bearing area of the medial tibial plateau in 9 knees and were normal in 12. The disease entity was documented most clearly by intense radionuclide bone uptake in the medial tibial plateau in all knees. It could be distinguished clinically and radiologically from medial femoral ON, tibial stress fractures and primary osteoarthritis (OA). Tibial ON did not appear to accelerate the development or progression of OA of the knee and most patients were better in less than 1 year.
9.4% of the patients sustaining cranio-cerebral injury also suffer from femoral fractures. Only those patients who undergo operation and internal fixation during the first week either by nailing or plating recover completely without any orthopedic disability. Conservative treatment or late orthopedic surgical intervention almost always resulted in permanent locomotor disability. It is concluded that early surgical intervention by either nailing or plating of femoral fractures helps in nursing, prevents deformity and leads to the complete recovery of these fractures in patients suffering from concomitant cranio-cerebral injuries.