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Biomedical subjects

M Linquette

Publications and source records attributed to M Linquette.

At least 307 records · Page 17Linked to original sources
PubMedDate not supplied

[The thyroxine hyperthyroidism (author's transl)].

24 of all patients observed between 1974 and 1976 suffering from thyrotoxicosis were found to have increased blood thyroxine (T4) levels without increased triiodothyronine ones. T4 hyperthyroidisms represented 3.5% of all hyperthyroidisms observed; they were in relation with Grave's disease (18 patients) or toxic nodular (6 patients); clinical pictures were quite usual; old age, severe illnesses, amiodarone and corticoids treatments, iodine excess, were sometimes being incriminated, but often no particular cause could be found. Preferential T4 secretion or impaired peripheral T4 conversion are two possible mechanisms of T4 hyperthyroidism.

Adult↗
PubMedDate not supplied

[Test of pituitary adrenal restraining with IV dexamethasone in the diagnosis of Cushing's syndrome (author's transl)].

The authors report a pituitary adrenal retraining test, using a 4 h IV infusion of dexamethasone phosphate (4 mg). Plasma cortisol is measured before and at the end of the infusion. The results allow a good discrimination between Cushing's disease (bilateral adrenal hyperplasia : 9 cases) and Cushing's syndrome of tumorous origin (adrenal tumors 7 cases, ectopic ACTH syndrome 3 cases, hypophyseal adrenomas 2 cases), only bilateral adrenal hyperplasia cases are lowering significantly.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

[Hormonal profile in anorexia nervosa under control. Correlations with various somatic factors].

In order to precise the hormonal pattern of Anorexia Nervosa (AN) at its state phase, we assessed serum estradiol (E2), triiodothyronine (T3), LH and FSH, the maximum increments of their response to 100 microgram LHRH (delta LH and delta FSH) and the ratio of these increments (delta LH/delta FSH). These data were compared with those obtained in 10 normal women assessed at the early follicular phase (Student's test). Furthermore in 20 cases, we assessed LH and FSH during 5 days after a 20 mg IV injection of PREMARIN. E2, T3, LH and FSH are often decreased in AN. On the average, this decrease is very significant for the 3 first ones (p less than 0.001), and slightly significant for FSH (p less than 0,05). The LHRH-response is variable, with an inversion of the LH/FSH ratio as before the puberty in 56% of the cases. On the average, FSH-response is increased (p less than 0,05), and LH-response is normal. The response is delayed for the both gonadotropins. After PREMARIN, the 2 gonadotropins rarely clearly decrease (twice for LH and 5 times for FSH). There is a LH peak only in 3 cases. In order to specify the origin of these anomalies, we searched correlations between 11 hormonal data and some somatic parameters : weight, time, menstrual antecedents. We found 26 statistically significant correlations (12 times p less than 0,05- 5 times p less than 0,001- 9 times p less than 0,001). The following correlations are significant : E2 and LH, E2 and the maximal decrease of LH after PREMARIN (negative correlation), T3 and FSH, delta LH, and delta FSH, duration of the amenorrhea and T3, FSH and delta FSH, the weight and delta LH, the weight and delta LH/delta FSH, weight/height and delta LH/delta FSH, the menstrual antecedents and FSH. So, somatic factors strongly influence the hormonal pattern at the AN-state phase. The weight-decrease, the T3-decrease, and above all the E2-decrease which is independent of the previous ones seem to be the determining elements of the AN-hormonal pattern at this phase.

Adolescent↗
PubMedDate not supplied

[Surgical treatment of Graves' disease : a survey (author's transl)].

A follow up study of 63 patients treated by subtotal thyroidectomy for diffuse toxic goitre was reported. The patients were operated when they were euthyroid, after a prolonged treatment with carbimazole and a short one with iodide solution. Only 3 or 4 g. of thyroid tissue remained after surgery. No serious complication, specially ocular, was seen. No patient was hyperthyroid 6 months after surgery and only one relapsed after 2 years. Hypothyroidism was observed in 35 % of cases within the 6 months after surgery and was increased up to 50 % after 5 years.

Adult↗
PubMedDate not supplied

[Low triiodothyronine syndrome in non thyroidal diseases. Distribution and serum TSH concentration studies (author's transl)].

Thyroid explorations were made in 57 patients complaining of serious illnesses in order to identify "low T3 syndrome". All these patients were clinically euthyroid as assessed by normal values of T4 concentration, RT3U ratio and FT4I. However, all the patients included in this study had significantly low serum T3 (42 +/- 29 ng/100 ml) and FT3I (0,44 +/- 0,30). Low T3 syndrome was particularly frequently seen in patients with cancer (8/10), hepatic cirrhosis (5/6), renal failure (6/7), old age (5/8) and in serious systemic diseases (6/12). Nevertheless, at adverse with other authors, we have observed less frequently the low T3 syndrome in anorexia nervosa (4/6) as well as during fasting (1/8). In 31 out of 35 patients with low or normal low T3 concentrations, the serum TSH values observed were within the normal limits in 28 cases. The etiologies of isolated decreased T3, mainly the deviation of peripheral conversion of T4 to reverse T3, are discussed. Normal metabolic state and normal TSH concentration encountered in the low T3 syndrome are equally commented.

Aged↗
PubMedDate not supplied

[Inhibition of prolactin release by methysergide and bromocriptine in hyperprolactinemic subjects: comparative dynamic studies (author's transl)].

Reduction of hyperprolactinemia by Methysergide (4.4 mg p.o.) and Bromocriptine (2.5 ng p.o.) was studied in 20 patients (7 subjects with pituitary macroadenoma and 13 hyperprolactinemic patients with normal sella turcica). No difference was observed between the effects of the two drugs 4 hours after their administration, with and without respect of the aetiologies of hyperprolactinemia. However the serum prolactin levels were significantly lower 6 hours (n = 11 p = 0,01) and 12 hours (n = 10 p less than 0,01) after Bromocriptine than after methysergide. The difference observed between the two drugs seems to be inherent to their different half-lives.

Adenoma↗