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Biomedical subjects

M Linquette

Publications and source records attributed to M Linquette.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

Prolactin regulation in 14 cases of galactorrhea and hypogonadism with minimal modifications of the sella turcica (author's transl).

In this study we report 13 cases of amenorrhea-galactorrhea and one of a male patient complaining of gynecomastia, galactorrhea, sexual impotence and sterility with oligoasthénospermy. In these cases, the size of the sella turcica was normal but we found a localized depression of the bottom of the sella turcica; these modifications were situated at the antero-inferior part of the sella in 12 cases and posteriorly in the 2 others. Basal prolactin level was higher than normal values in 13 cases (12 female and 1 male patients): individual values varied between 45 and 367 ng/ml. Nycthermeral rhythm disappeared in the 9 cases studied. Administration of L-Dopa (500 mg orally) significantly suppressed the prolactin values in the 11 cases studied. Oral water loading (20 ml/kg) left prolactin values unchanged (10 cases). After oral glucose tolerance test (1 g/kg) no significant systematic variation occurred. The increase of prolactin values after stimulation by 200 microg. TRH IV as a bolus (4 cases) was not significant. We have found similar prolactin variations in cases of hyperprolactinemia with either normal pituitary fossa (7 cases) or macro-adenoma (6 cases).

Adenoma↗
PubMedDate not supplied

[Production rate and mean plasma concentration of cortisol in hyperthyroidism (author's transl)].

The adrenocortical function was studied in 23 patients with hyperthyroidism. The half-life of tritiated cortisol was significantly shortened; metabolic clearance rate was about twice increased, and production rate of cortisol was significantly increased in hyperthyroidism. The mean plasma concentration was unmodified. After return to euthyroid state, all the values were normalized in 7 patients.

17-Hydroxycorticosteroids↗