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Biomedical subjects

M Linde

Publications and source records attributed to M Linde.

35 records · Page 2Linked to original sources
PubMed1990

Sexual function in married men with Parkinson's disease compared to married men with arthritis.

We evaluated the sexual function of 41 married men with Parkinson's disease (PD) and its relation to age, severity of PD, and depression. We used a group of 29 married men with arthritis for comparison. Total sexual functioning and categories of desire, arousal, orgasm, and satisfaction did not differ significantly between patients with PD and arthritis. For both PD and arthritis, increased age, severity of illness, and depression were associated with reduced sexual function. These results suggest that sexual dysfunction is common in married men with PD, but no more so than in men with another chronic illness that does not involve the nervous system.

Adult↗
PubMed1989

Negative effects of famotidine on cardiac performance assessed by noninvasive hemodynamic measurements.

In a randomized placebo-controlled study 12 healthy volunteers were treated for 1 wk each with 10 mg of nifedipine four times daily plus placebo or the same dose of nifedipine concurrently with 40 mg of famotidine once a day. Famotidine did not significantly alter pharmacokinetic parameters of nifedipine. Determination of systolic time intervals showed that the preejection period and the ratio of the preejection period and the left ventricular ejection time were significantly reduced by administration of nifedipine plus placebo. Coadministration of famotidine and nifedipine, however, led to a significant increase of these parameters. In an additional double-blind study, a significant rise of the preejection period and of the ratio was detected after administration of famotidine alone. In impedance cardiography stroke volume and cardiac output were significantly reduced by famotidine. Heart rate and blood pressure values were not altered by the H2-antagonist. For the first time, to our knowledge, the observed changes of hemodynamic parameters appear to indicate that famotidine may exert negative effects on cardiac performance which, in our opinion, could be of clinical relevance in elderly subjects or in patients with heart failure.

Adult↗
PubMed1989

[Mechano- and impedance cardiography parameters in patients with heart failure in administration of a calcium antagonist. The significance of the Heather index].

By means of impedance- and mechanocardiography the effect of the calcium-channel blocker nisoldipine on the circadian course of hemodynamic parameters was measured in a placebo-controlled randomized double-blind study in 18 patients with heart failure (NYHA II). A significant effect of nisoldipine on left ventricular function was observed after 2 h but not any more 6 h following the administration of the drug. This effect was expressed by a reduction of the pre-ejection period (PEPc) and PEP/LVET in the systolic time intervals (STI) and a rise in stroke volume (delta V) and cardiac output (CO), as well as an increase of the Heather-index in impedance cardiography (ICG). In ICG the Heather-index proved to be a more reliable parameter of left ventricular function than the calculation of stroke volume and cardiac output, respectively. This is probably due to the fact that the distance between the electrode (L) is not considered for the Heather-index, while it has to be taken into account for determining stroke volume and cardiac output. When performing impedance cardiography in the elderly, the distance between the electrodes may be a source of error because of a lack of cooperation, possible underlying corpulance, or due to a restricted motility of the chest or the vertebral column. In these patients the Heather-index should be preferred to the calculation of stroke volume and cardiac output, whereas in healthy subjects the latter parameters seem to be of sufficient validity.

Aged↗
PubMed1988

[Negative inotropic action of famotidine].

In a randomized placebo-controlled study, 12 healthy volunteers were treated for one week each with nifedipine 10 mg four times daily or the same dose of nifedipine concurrently with famotidine 40 mg once daily per os. Famotidine did not significantly alter pharmacokinetic parameters of nifedipine. Determination of systolic time intervals showed that pre-ejection period (PEPc) and the ratio of pre-ejection period over left ventricular ejection time (PEP/LVET) were significantly reduced by administration of nifedipine plus placebo. Coadministration of famotidine and nifedipine, however, led to a significant increase in these parameters. Also, administration of famotidine alone to the same subjects led to a significant rise in PEPc and PEP/LVET. In impedance cardiography, stroke volume and cardiac output were significantly reduced by famotidine, whereas the H2-antagonist did not alter heart rate. This observation indicates for the first time that famotidine may exert negative effects on cardiac performance. In our opinion this could be of clinical relevance in elderly subjects or in patients with heart failure.

Adult↗
PubMed1980

[The unusual case: Wegener's granulomatosis].

In a casuistic report of a case of Wegener's granulomatosis the diagnostic and therapeutic problems of a relatively rare clinical picture are described. Special emphasis is laid on the variety of organic manifestations and on the fact that bioptic investigations have not resulted in typical findings leading to diagnosis. Despite immunosuppressive therapy the lethal exitus cannot be influenced.

Adult↗
PubMed1979

[The value of endoscopic retrograde cholangiopancreaticography in the diagnosis of bile duct and pancreatic diseases. Results of 756 studies].

Endoscopic retrograde cholangiopancreatography was successful in 626 of 756 examinations (82,8%). Choledocholithiasis in view of bile ducts and chronic pancreatitits on the score of bile ductal system are the most lesions we could observe. An acute pancreatitis in 2 cases and an infection of a pancreatic pseudocyst in 1 case were the 3 complications in our material. Meanwhile the rate of successful cannulations reached more than 90%.

Acute Disease↗
PubMedDate not supplied

Utility of the sickness impact profile in Parkinson's disease.

The Sickness Impact Profile (SIP) is a questionnaire consisting of 136 items grouped into 12 categories and two dimensions (physical and psychosocial). To characterize its utility in Parkinson's disease (PD), we administered the SIP to 44 consecutive clinic patients with PD. Compared to 44 age- and sex-matched control subjects, PD patients had their greatest dysfunction in the categories of mobility, communication, and home management. The two items that PD patients most commonly endorsed were, "I am having trouble writing or typing" (75%) and, "My sexual activity is decreased" (61%). In general, these treated PD patients had greater dysfunction in the psychosocial than physical dimensions. Two simple PD-specific scales correlated well with the physical dimension score but less so with the psychosocial dimension, suggesting that the SIP assesses more functional domains than the PD-specific scales used. The SIP holds some promise as a broad measure of functional status in PD patients.

Activities of Daily Living↗