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Biomedical subjects

M Licea Puig

Publications and source records attributed to M Licea Puig.

12 recordsLinked to original sources
PubMed1996

[Studies of cardiovascular autonomic function and duration of QTc interval in smokers].

OBJECTIVES: A total of 97 apparently healthy subjects were studied in order to establish the influence of smoking habits in studies on neurocardiovascular control and the QTc interval duration. MATERIAL AND METHODS: The study group consisted of 37 smokers and 60 non-smokers as the control. A 12-lead electrocardiogram was performed on all subjects to determine the duration of the QTc interval. Other aspects studied include heart rate variability at rest during 150 cardiac cycles using time domain: coefficient of variation and root mean squared successive difference; and frequency domain: low frequency band (0.04-0.15 Hz) and high frequency band (0.15-0.50 Hz), to determine total energy logarithm and maximum energy frequency. Additionally, conventional cardiovascular autonomic function tests, such as orthostasis, Valsalva maneuver and deep breathing were performed. RESULTS: No significant differences were observed in the duration of the QTc interval nor in time and frequency domain parameters, except in the maximum frequency in the high frequency band, which appeared significantly lower (p < 0.05) in smokers when compared to non-smokers (0.28 +1- 0.1 vs 0.33 +/- 0.1 Hz). No modifications were noted in the cardiovascular autonomic function tests applied to smokers and non-smokers, and the QTc interval was not linked to the rest of the variables studied. CONCLUSIONS: To conclude, smoking habits do not seem to have a significant influence in studies addressed to determine the impact of the autonomic nervous systems on cardiovascular control.

Adolescent↗
PubMed1989

[Correlation of the levels of glycosylated hemoglobin and total cholesterol, total triglycerides and HDL cholesterol in a sample of insulin-dependent diabetics].

In 132 insulin-dependent diabetics (type I), between 15 and 45 years old (73 women and 59 men) glycosylated hemoglobin (HbA1), total cholesterol (TC), HDL-cholesterol (HDL-C) and total triglycerides (TG) have been determined. We observed that sex did not significantly influence the parameters studied. In the younger group of patients (aged between 15 and 30 years) HbA1, TC, TG were significantly greater than in the older group of patients (p less than 0.05 and p less than 0.01, respectively). In this series, an elevated correlation among HbA1 and TG levels was found. This was also found, although to a lesser extent, when considering TC levels (r = 0.45, p less than 0.05). However, no correlation between HbA1 and HDL-C was found in the total sample or regarding age. These results allow us to point out the usefulness and the application of HbA1 determination in evaluating the relationship between carbohydrate and lipid metabolism in type 1 diabetics.

Adolescent↗
PubMedDate not supplied

[Glycosylated hemoglobin as a prognostic index of the appearance of vascular complications in diabetic patients].

One hundred and fourty seven diabetic patients of both sexes with ages between 40 and 65 (44% Type 1 and 56% Type II), were studied and followed for a period of five years in order to evaluate the possible association between blood glucose control and the appearance and progression of vascular complications. A clinical metabolic characterization was performed in all patients both at the beginning and at the end of the study. Process of the results after 5 years was carried out dividing the total study sample in two groups, A and B, according to the level of glycosylated hemoglobin (HbA1) at the beginning of the study (HbA1 less than 10% or greater than 10%). The most frequent vascular complications both at the beginning and at the end of the study were retinopathy, hypertension, and angina pectoris, outstanding the high incidence of retinopathy (83%) found at the end of the study in the group of patients who were considered poorly controlled given the initial HbA1 values. A subset of 111 patients who did not present retinopathy at the beginning of the study were particularly analyzed, demonstrating in these cases a significant association between HbA1 levels at the beginning of the study and the appearance of retinopathy five years later. Type II diabetics particularly showed a 3 fold risk of developing this complication if their initial HbA1 levels were equal to or higher than 10%. This finding gives HbA1 determination a predictive value for the development of retinopathy and highlights the influence of glycemic control on the appearance and progression of this complication in diabetic patients.

Adult↗