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Biomedical subjects

M Levy

Publications and source records attributed to M Levy.

At least 649 records · Page 36Linked to original sources
PubMed1977

The prediction of tumor regression in human squamous carcinoma by means of the potential tumor doubling time.

Thirty-three patients with locally advanced epidermoid cancer of the mouth were investigated by means of the potential tumor doubling time prior to each of four weekly infusions of methotrexate. The agent used to induce metaphase arrest was vincristine sulphate 2 mg intravenous push and the methotrexate was given in a dose of 100 mg/M2 body surface. In twenty-one patients the investigation was completed. It was found that in those patients where the P.T.D.T. was maintained at its original level there was a greater than 50% reduction in the size of the lesion, whereas when the P.T.D.T. became greatly prolonged there was no such reduction. It is suggested that the P.T.D.T. provides a simple same day method of evaluating one parameter in the cell kinetics of accessible tumors and that this information can be used to individualize chemotherapy schedules.

Carcinoma, Squamous Cell↗
PubMed1977

Fractures of the femoral neck in childhood. Results of conservative treatment.

Experience with nine patients with fracture of the femoral neck in childhood, eight of whom were treated conservatively by closed reduction and fixation with a plaster cast, and one in whom Steinmann pins and open reposition had to be employed to accomplish fixation, is presented in brief. In six children the results were evaluated as good and in three (including the one case of open reduction) as fair. No serious complications were observed. The problem of nonsurgical versus surgical approach is discussed in the light of the relevant literature. It is suggested that while there can be no set rule as to which treatment should be used, conservative management yields results which are comparable with those attained with a more aggressive approach.

Adolescent↗
PubMed1977

Sodium retention and ascites formation in dogs with experimental portal cirrhosis.

Experimental cirrhosis was produced in dogs by the sporadic feeding of dimethylnitrosamine for the purpose of studying the temporal relationships between urinary sodium retention, plasma volume expansion, and ascites formation. Sodium retention started about 16 days following the onset of cirrhosis and preceded ascites formation by about 10 days. Plasma volume increased by 9% (P less than 0.05) within 3-4 days of sodium retention and expanded further as ascites accumulated. Splanchnic plasma volume was greater by 161 ml in 10 cirrhotic dogs with ascites than in 14 normal dogs. Nonsplanchnic volume was greater by 96 ml (P less than 0.05). Thus, the "effective" as well as the splanchnic component of the vascular space was expanded. Paracentesis did not cause the re-formation of ascites in five dogs as long as dietary salt was denied. Refeeding permitted reaccumulation of ascites and further plasma volume expansion. Renal perfusion remained constant as dogs became progressively cirrhotic. We conclude that ascites formation depends on the prior retention of urinary sodium, and occurs as an "overflow" phenomenon. A contracted effective plasma volume does not appear to be necessary for continuing sodium retention.

Animals↗
PubMed1977

Medical and educational malpractice issues in patient education.

This paper discusses the concept of educational malpractice as a cause of prolonged patient morbidity equal in magnitude to medical malpractice. Statements by national groups sanctioning and urging increased patient education efforts are reviewed. An example of specially designed problem-oriented patient education materials development, the concept of an "Educational Prescription," the place for the "Educational Prescription" in problem-oriented medical records, and the value of hospital-based patient education as a cost-containment activity.

Hospitals↗
PubMed1977

Drug utilization and adverse drug reactions in medical patients: comparison of two periods, 1969--72 and 1973--76.

A study of drug usage and adverse drug reactions was carried out on 2,771 hospitalized medical patients during 1969--76. Comparison of data between 1969--72 and 1973--76 shows an 11% reduction in the average number of drugs per patient, and a 59% decrease in the incidence of adverse effects, calculated as percent of all exposures. The number of patients affected by adverse reactions during the second period fell by 61%. These data seem to indicate that there was considerable improvement in habits of drug usage in the monitored ward.

Adult↗
PubMed1976

Human umbilical cord. A new source for vascular prosthesis.

Reconstructions were performed to the popliteal, tibial, and peroneal arteries employing a modified umbilical cord vein prosthesis. The latter was obtained from human cords and was made available as an onshelf graft for surgery following glutaraldehyde tanning. The early patency and limb salvage rates are equivalent to those obtained with autogenous saphenous veins. Additional benefits include significant decreased operative time and morbidity. It is also probable that this new graft may be resistant to biodegradation and therefore may obviate many of the causes for late failure that occur with the use of living biologic tissues or collagen tubes. Long-term follow-up and study are essential to validate the results obtained thus far and to assess the potential of this new graft in a variety of vascular reconstructions.

Aged↗
PubMed1976

Purification and characterization of two forms of urokinase.

Affinity chromatography on agmatine-Sepharose was used for the separation of two active forms of urokinase (EC 3.4.99.26) from partially purified human urinary urokinase. The approximate molecular weight of the heavier form was 47 000 and of the lighter 33 400. Both forms were homogeneous by sodium dodecyl sulfate gel electrophoresis and by 3H-labeled diisopropylphosphorofluoridate and 14C-labeled p-nitrophenyl-p'-guanidinobenzoate incorporation studies. The 33 400 mol. wt. form had a single chain, and the 47 000 mol. wt. form had two chains (33 100 and 18 600 mol. wt.) linked by disulfide bonds. The specific activity of the heavier form was 104 000 CTA units/mg protein, compared with 226 000 units/mg for the lighter form but the activities per mmol of active site (molar activities) of the two forms were almost identical (9.6-10(9) and 10.2-10(9) CTA units/mmol). Isoelectric focusing on gels showed that the 47 000 material contained one major subform with a pI of 8.60 and a minor subform with a pI of 8.90, while the 33 400 material had three major subforms with pI values of 8.35, 8.60 and 8.70, respectively, and a minor subform with a pI of 8.05. 3H-labeled diisopropylphosphorofluoridate incorporation studies revealed an active-site serine residue in the heavy chain.

Amino Acids↗
PubMed1976

[Beta-Hydroxybutyrate dehydrogenase of rat liver inner mitochondrial membrane. Its isolation, characterization, and reactivation by lecithins differing in their apolar regions. The influence of the addition of cholesterol on its level of reactivation (author's transl)].

The beta-hydroxybutyrate dehydrogenase has been isolated and purified from the inner mitochondrial membrane of the rat liver. It consists in a dimer of molecular weight 77 000 composed by two subunits of molecular weight 38 000 each. The level of its reactivation by lecithin is influenced by the length and degree of unsaturated of their aliphatic chains. The addition of cholesterol inhibits the reactivation.

Animals↗