A histopathologic study of the heart in gargoylism.
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Biomedical subjects
Publications and source records attributed to M Lev.
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Lev, Meir (Albert Einstein College of Medicine, New York, N.Y.), Raymond H. Alexander, and Stanley M. Levenson. Stability of the Lactobacillus population in feces and stomach contents of rats prevented from coprophagy. J. Bacteriol. 92: 13-16. 1966.-Lactobacilli were enumerated in the feces of rats prevented from coprophagy by tail-cupping. No differences were found when numbers of these organisms were compared with lactobacilli in feces of control rats, without tail-cups. High and similar numbers of lactobacilli were found in the stomachs of rats with and without tail-cups. The effect of coprophagy on fecal lactobacilli was therefore negligible.
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A patient with sudden onset of hemiplegia was noted to have an anomalous mitral arcade at cardiac surgery. Echocardiographic and angiographic data are correlated with the anatomic findings. The clinical significance of this anomaly is discussed.
The angiocardiograms of 5 newborn infants with autopsy and/or surgically-proven congenital absence of the ductus arteriosus (ADA) and right ventricular outflow obstruction (Group A), and of 14 neonates with pulmonary atresia complex and patent ductus arteriosus (Group B) were reviewed. Aortic size was similar in both groups; however, the diameters of the right and left pulmonary arteries were much smaller in Group A than in Group B (right pulmonary artery: 2.6 vs 4.5 mm, P less than 0.005; left pulmonary artery: 2.5 vs 4.3 mm, P less than 0.005). Extensive bronchial collaterals were observed in Group A but not in Group B. Tricuspid aortic valve stenosis was present in 2 patients in Group A but in none in Group B. The diagnosis of ADA may be made in newborn infants with severe right ventricular outflow obstruction if the angiocardiograms reveal hypoplasia of the pulmonary arteries, extensive bronchial collaterals, and nonvisualization of the ductus arteriosus. Other suggestive features include aortic valve stenosis and/or right aortic arch with aberrant left subclavian artery.
This is the first autopsied case reported in the English language literature wherein the right superior vena cava entered both atria with obstruction of the entry into the right atrium, aneurysmal dilatation of the proximal part of the superior vena cava, and entry of the stenosed right upper pulmonary vein into the aneurysmal sac. The aneurysmally dilated right superior vena cava communicated directly with the left atrium. In addition, the remainder of the pulmonary veins, all of which were markedly stenosed, entered the left atrium. The embryogenesis of this unique malformation is briefly discussed.
A dysplastic pulmonic valve in hypoplasia of aortic tract complex has not been dealt with in the literature. The recent attempted surgical correction for hypoplasia of aortic tract complex has given some hope of survival in this entity. The integrity of the tricuspid and pulmonic valves is important while considering total surgical correction. We describe three hearts of hypoplasia of aortic tract complex with dysplastic pulmonic valve. The echocardiographic recognition and the significance of the dysplastic nature of the pulmonary valve in the light of surgery are emphasized.
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